Modulation of activated oncogene c-kit expression with RNA-interference

Overexpression of oncogene c-kit is detected in 80% patients with acute myeloid leukemia (AML). A transgenic model cell line expressing oncogene c-kit was obtained by transduction with a recombinant retrovirus. We have designed small interfering RNAs (siRNAs) that efficiently suppress the expression...

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Veröffentlicht in:	Molecular biology (New York) 2011-12, Vol.45 (6), p.950-958
Hauptverfasser:	Spirin, P. V., Nikitenko, N. A., Lebedev, T. D., Rubtsov, P. M., Stocking, C., Prasolov, V. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Biochemistry Biomedical and Life Sciences c-Kit protein Cell culture Gene expression Human Genetics Leukemia Life Sciences Molecular biology Molecular Biology of the Cell mRNA Oncogenes Retrovirus Ribonucleic acid RNA siRNA
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