Polymer nanoparticles containing tumor lysates as antigen delivery vehicles for dendritic cell–based antitumor immunotherapy

Abstract Encapsulation of tumor-associated antigens in polymer nanoparticles (NP) is a promising approach to enhance efficiency of antigen delivery for anti-tumor vaccines. Head and neck squamous carcinoma (HNSCC) cell lines were initially used to generate tumor-associated antigens (TAA)-containing...

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Veröffentlicht in:	Nanomedicine 2011-02, Vol.7 (1), p.1-10
Hauptverfasser:	Prasad, Shashi, FRCS, Cody, Virginia, BS, Saucier-Sawyer, Jennifer K., BS, Saltzman, W. Mark, PhD, Sasaki, Clarence T., MD, Edelson, Richard L., MD, Birchall, Martin A., FRCS, Hanlon, Douglas J., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen (tumor-associated) Antigen delivery Antigen presentation Blood Carcinoma CD8 antigen Cell Line, Tumor Cells, Cultured Cytotoxicity Dendritic cell Dendritic cells Dendritic Cells - cytology Dendritic Cells - physiology Encapsulation gamma -Interferon Head and neck cancer Hemopoiesis Humans Immunostimulation Immunotherapy Immunotherapy - methods In Vitro Techniques Interleukin 10 Internal Medicine Kinetics Lymphocytes T Malignancy Microscopy, Electron, Scanning Monocytes Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure nanotechnology Neoplasms - therapy polylactide-co-glycolide Polymers Polymers - chemistry Stem cells Toxicity Tumor cell lines Tumor cells Tumors Vaccines
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