Dynamic contrast-enhanced MRI as a predictor of tumour response to radiotherapy
Summary A predictive technique in the management of patients with cancer could improve the therapeutic index by allowing better individualisation of treatment. The standard risk factors that are currently used do not adequately account for the unpredictable and substantial variation seen in the trea...
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| Veröffentlicht in: | The lancet oncology 2007, Vol.8 (1), p.63-74 |
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| container_title | The lancet oncology |
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| creator | Zahra, Mark A, Dr Hollingsworth, Kieren G, PhD Sala, Evis, FRCR Lomas, David J, FRCR Tan, Li T, FRCR |
| description | Summary A predictive technique in the management of patients with cancer could improve the therapeutic index by allowing better individualisation of treatment. The standard risk factors that are currently used do not adequately account for the unpredictable and substantial variation seen in the treatment response of patients with a similar risk profile. Dynamic contrast-enhanced (DCE) MRI is a non-invasive technique that can provide anatomical and physiological information on the tumour. The DCE-MRI data reflects the tumour microenvironment variables that are known to influence radiation response. The aim of this review is to describe the potential clinical application of DCE-MRI as a predictor of radiation response. We have reviewed the literature and identified 29 studies (total of 1194 patients) that correlate DCE-MRI with histopathological or clinical outcome data relevant to radiotherapy. |
| doi_str_mv | 10.1016/S1470-2045(06)71012-9 |
| format | Article |
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The standard risk factors that are currently used do not adequately account for the unpredictable and substantial variation seen in the treatment response of patients with a similar risk profile. Dynamic contrast-enhanced (DCE) MRI is a non-invasive technique that can provide anatomical and physiological information on the tumour. The DCE-MRI data reflects the tumour microenvironment variables that are known to influence radiation response. The aim of this review is to describe the potential clinical application of DCE-MRI as a predictor of radiation response. 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The standard risk factors that are currently used do not adequately account for the unpredictable and substantial variation seen in the treatment response of patients with a similar risk profile. Dynamic contrast-enhanced (DCE) MRI is a non-invasive technique that can provide anatomical and physiological information on the tumour. The DCE-MRI data reflects the tumour microenvironment variables that are known to influence radiation response. The aim of this review is to describe the potential clinical application of DCE-MRI as a predictor of radiation response. We have reviewed the literature and identified 29 studies (total of 1194 patients) that correlate DCE-MRI with histopathological or clinical outcome data relevant to radiotherapy.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>17196512</pmid><doi>10.1016/S1470-2045(06)71012-9</doi><tpages>12</tpages></addata></record> |
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| subjects | Cancer Cell death Chemotherapy Contrast Media Data processing Hematology, Oncology and Palliative Medicine Humans Hypoxia Magnetic Resonance Imaging Medical prognosis Microenvironments Neoplasms - diagnostic imaging Neoplasms - pathology Neoplasms - radiotherapy Patients Permeability Radiation Radiation therapy Radiotherapy Reviews Risk factors Therapeutic applications Tumors Ultrasonography |
| title | Dynamic contrast-enhanced MRI as a predictor of tumour response to radiotherapy |
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