PDGFR Signaling Blockade in Marrow Stroma Impairs Lung Cancer Bone Metastasis

Bone microenvironment and cell-cell interactions are crucial for the initiation and development of metastasis. By means of a pharmacologic approach, using the multitargeted tyrosine kinase inhibitor sunitinib, we tested the relevance of the platelet-derived growth factor receptor (PDGFR) axis in the...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2011, Vol.71 (1), p.164-174
Hauptverfasser:	CATENA, Raúl, LUIS-RAVELO, Diego, ANTON, Iker, ZANDUETA, Carolina, SALAZAR-COLOCHO, Pablo, LARZABAL, Leyre, CALVO, Alfonso, LECANDA, Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - pharmacology Animals Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis - drug effects Biological and medical sciences Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Bone Neoplasms - prevention & control Bone Neoplasms - secondary Cell Adhesion - drug effects Cell Line Cell Proliferation - drug effects Diseases of the osteoarticular system Gene Expression Profiling Humans Indoles - pharmacology Lung Neoplasms - pathology Medical sciences Mice Neoplasm Invasiveness Pharmacology. Drug treatments Pneumology Pyrroles - pharmacology Receptors, Platelet-Derived Growth Factor - antagonists & inhibitors Receptors, Platelet-Derived Growth Factor - metabolism Signal Transduction Stromal Cells - drug effects Stromal Cells - metabolism Tumors Tumors of striated muscle and skeleton Tumors of the respiratory system and mediastinum
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