Tamoxifen decreases ovarian follicular loss from experimental toxicant DMBA and chemotherapy agents cyclophosphamide and doxorubicin in the rat
Introduction We serendipitously observed a protective effect of tamoxifen against depletion of ovarian follicles by 7,12-dimethylbenzanthracene (DMBA), a chemical carcinogen, during a cancer prevention study. Such ovarian protection is being sought as an alternative approach to fertility preservatio...
Gespeichert in:
| Veröffentlicht in: | Journal of assisted reproduction and genetics 2010-11, Vol.27 (11), p.591-597 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 597 |
|---|---|
| container_issue | 11 |
| container_start_page | 591 |
| container_title | Journal of assisted reproduction and genetics |
| container_volume | 27 |
| creator | Ting, Alison Y. Petroff, Brian K. |
| description | Introduction
We serendipitously observed a protective effect of tamoxifen against depletion of ovarian follicles by 7,12-dimethylbenzanthracene (DMBA), a chemical carcinogen, during a cancer prevention study. Such ovarian protection is being sought as an alternative approach to fertility preservation in human cancer patients.
Methods
Rats received tamoxifen (0, 1 mg or 2.5 mg/kg/d) and DMBA (0, 1, 2 mg/kg/wk) or cyclophosphamide (0, 35, 50 mg/kg/wk). Ovarian follicles were quantified and effects on fertility and litter size were tested. Cultured oocytes were exposed to chemotherapy drug doxorubicin, with or without 4-hydroxytamoxifen (4HT).
Results
DMBA and cyclophosphamide decreased the number of primordial and total follicles, and this reduction was prevented by tamoxifen. Cyclophosphamide tended to reduce fertility and lessened neonatal survival. Tamoxifen reversed these defects. Doxorubicin caused oocyte fragmentation which was prevented by 4HT.
Conclusions
Tamoxifen decreases follicle loss and improves reproductive function following exposure to ovarian toxicants including chemotherapy drugs in the female rat. |
| doi_str_mv | 10.1007/s10815-010-9463-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_954616859</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>954616859</sourcerecordid><originalsourceid>FETCH-LOGICAL-p242t-9af896c0b5e8df3317148d9ded681f3b6d0691cba7a031e4faae89271260273f3</originalsourceid><addsrcrecordid>eNpdkc1q3TAQhU1paNK0D9BNEd105XbGsmV5maa_kJBNuhZjaZzrYFuuZIfrp-grR7c3pVAYmIH5zjCck2VvED4gQP0xImisckDIm1LJfHuWnWFVy7yWEp6nGSqdQ6n0afYyxnsAaHQhX2SnBdSIdYVn2e9bGv2-73gSjm1gihyFf6DQ0yQ6Pwy9XQcKYvAxii74UfB-5tCPPC00iCVpLU2L-Hz96ULQ5ITd8eiXHQeaN0F3CYvCbnbw887HeUdj7_gP6Pzeh7XtbT-JVEkiAi2vspOOhsivn_p59vPrl9vL7_nVzbcflxdX-VyUxZI31OlGWWgr1q6TEmsstWscO6Wxk61yoBq0LdUEErnsiFg3RY2FgqKWnTzP3h_vzsH_WjkuZuyj5WGgif0aTVOVCpWumkS--4-892uY0nMmmS8LBDxAb5-gtR3ZmTk5RGEzf41OQHEEYlpNdxz-XUEwhzTNMU2T0jSHNM0mHwGnjJLy</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>815321019</pqid></control><display><type>article</type><title>Tamoxifen decreases ovarian follicular loss from experimental toxicant DMBA and chemotherapy agents cyclophosphamide and doxorubicin in the rat</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature - Complete Springer Journals</source><source>PubMed Central</source><creator>Ting, Alison Y. ; Petroff, Brian K.</creator><creatorcontrib>Ting, Alison Y. ; Petroff, Brian K.</creatorcontrib><description>Introduction
We serendipitously observed a protective effect of tamoxifen against depletion of ovarian follicles by 7,12-dimethylbenzanthracene (DMBA), a chemical carcinogen, during a cancer prevention study. Such ovarian protection is being sought as an alternative approach to fertility preservation in human cancer patients.
Methods
Rats received tamoxifen (0, 1 mg or 2.5 mg/kg/d) and DMBA (0, 1, 2 mg/kg/wk) or cyclophosphamide (0, 35, 50 mg/kg/wk). Ovarian follicles were quantified and effects on fertility and litter size were tested. Cultured oocytes were exposed to chemotherapy drug doxorubicin, with or without 4-hydroxytamoxifen (4HT).
Results
DMBA and cyclophosphamide decreased the number of primordial and total follicles, and this reduction was prevented by tamoxifen. Cyclophosphamide tended to reduce fertility and lessened neonatal survival. Tamoxifen reversed these defects. Doxorubicin caused oocyte fragmentation which was prevented by 4HT.
Conclusions
Tamoxifen decreases follicle loss and improves reproductive function following exposure to ovarian toxicants including chemotherapy drugs in the female rat.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-010-9463-y</identifier><identifier>PMID: 20711751</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>9,10-Dimethyl-1,2-benzanthracene ; 9,10-Dimethyl-1,2-benzanthracene - toxicity ; Animals ; Antineoplastic Agents - toxicity ; Cancer ; Cancer therapies ; Carcinogens ; Cells, Cultured ; Chemotherapy ; Cyclophosphamide ; Cyclophosphamide - toxicity ; Cytotoxicity ; Disease prevention ; Doxorubicin ; Doxorubicin - toxicity ; Drug dosages ; Drugs ; Female ; Fertility ; Fertility - drug effects ; Fertility Preservation ; Follicles ; Gynecology ; Human Genetics ; Infertility ; Laboratories ; Litter ; Medicine ; Medicine & Public Health ; Neonates ; Oocytes ; Oocytes - drug effects ; Ovarian cancer ; Ovarian Follicle - drug effects ; Ovary - drug effects ; Ovary - pathology ; Preservation ; Protective Agents - pharmacology ; Rats ; Rats, Sprague-Dawley ; Reproductive Medicine ; Survival ; Tamoxifen ; Tamoxifen - analogs & derivatives ; Tamoxifen - pharmacology ; Toxicants ; Vagina</subject><ispartof>Journal of assisted reproduction and genetics, 2010-11, Vol.27 (11), p.591-597</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p242t-9af896c0b5e8df3317148d9ded681f3b6d0691cba7a031e4faae89271260273f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10815-010-9463-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10815-010-9463-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20711751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ting, Alison Y.</creatorcontrib><creatorcontrib>Petroff, Brian K.</creatorcontrib><title>Tamoxifen decreases ovarian follicular loss from experimental toxicant DMBA and chemotherapy agents cyclophosphamide and doxorubicin in the rat</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Introduction
We serendipitously observed a protective effect of tamoxifen against depletion of ovarian follicles by 7,12-dimethylbenzanthracene (DMBA), a chemical carcinogen, during a cancer prevention study. Such ovarian protection is being sought as an alternative approach to fertility preservation in human cancer patients.
Methods
Rats received tamoxifen (0, 1 mg or 2.5 mg/kg/d) and DMBA (0, 1, 2 mg/kg/wk) or cyclophosphamide (0, 35, 50 mg/kg/wk). Ovarian follicles were quantified and effects on fertility and litter size were tested. Cultured oocytes were exposed to chemotherapy drug doxorubicin, with or without 4-hydroxytamoxifen (4HT).
Results
DMBA and cyclophosphamide decreased the number of primordial and total follicles, and this reduction was prevented by tamoxifen. Cyclophosphamide tended to reduce fertility and lessened neonatal survival. Tamoxifen reversed these defects. Doxorubicin caused oocyte fragmentation which was prevented by 4HT.
Conclusions
Tamoxifen decreases follicle loss and improves reproductive function following exposure to ovarian toxicants including chemotherapy drugs in the female rat.</description><subject>9,10-Dimethyl-1,2-benzanthracene</subject><subject>9,10-Dimethyl-1,2-benzanthracene - toxicity</subject><subject>Animals</subject><subject>Antineoplastic Agents - toxicity</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Carcinogens</subject><subject>Cells, Cultured</subject><subject>Chemotherapy</subject><subject>Cyclophosphamide</subject><subject>Cyclophosphamide - toxicity</subject><subject>Cytotoxicity</subject><subject>Disease prevention</subject><subject>Doxorubicin</subject><subject>Doxorubicin - toxicity</subject><subject>Drug dosages</subject><subject>Drugs</subject><subject>Female</subject><subject>Fertility</subject><subject>Fertility - drug effects</subject><subject>Fertility Preservation</subject><subject>Follicles</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Infertility</subject><subject>Laboratories</subject><subject>Litter</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neonates</subject><subject>Oocytes</subject><subject>Oocytes - drug effects</subject><subject>Ovarian cancer</subject><subject>Ovarian Follicle - drug effects</subject><subject>Ovary - drug effects</subject><subject>Ovary - pathology</subject><subject>Preservation</subject><subject>Protective Agents - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reproductive Medicine</subject><subject>Survival</subject><subject>Tamoxifen</subject><subject>Tamoxifen - analogs & derivatives</subject><subject>Tamoxifen - pharmacology</subject><subject>Toxicants</subject><subject>Vagina</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkc1q3TAQhU1paNK0D9BNEd105XbGsmV5maa_kJBNuhZjaZzrYFuuZIfrp-grR7c3pVAYmIH5zjCck2VvED4gQP0xImisckDIm1LJfHuWnWFVy7yWEp6nGSqdQ6n0afYyxnsAaHQhX2SnBdSIdYVn2e9bGv2-73gSjm1gihyFf6DQ0yQ6Pwy9XQcKYvAxii74UfB-5tCPPC00iCVpLU2L-Hz96ULQ5ITd8eiXHQeaN0F3CYvCbnbw887HeUdj7_gP6Pzeh7XtbT-JVEkiAi2vspOOhsivn_p59vPrl9vL7_nVzbcflxdX-VyUxZI31OlGWWgr1q6TEmsstWscO6Wxk61yoBq0LdUEErnsiFg3RY2FgqKWnTzP3h_vzsH_WjkuZuyj5WGgif0aTVOVCpWumkS--4-892uY0nMmmS8LBDxAb5-gtR3ZmTk5RGEzf41OQHEEYlpNdxz-XUEwhzTNMU2T0jSHNM0mHwGnjJLy</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Ting, Alison Y.</creator><creator>Petroff, Brian K.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20101101</creationdate><title>Tamoxifen decreases ovarian follicular loss from experimental toxicant DMBA and chemotherapy agents cyclophosphamide and doxorubicin in the rat</title><author>Ting, Alison Y. ; Petroff, Brian K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p242t-9af896c0b5e8df3317148d9ded681f3b6d0691cba7a031e4faae89271260273f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>9,10-Dimethyl-1,2-benzanthracene</topic><topic>9,10-Dimethyl-1,2-benzanthracene - toxicity</topic><topic>Animals</topic><topic>Antineoplastic Agents - toxicity</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Carcinogens</topic><topic>Cells, Cultured</topic><topic>Chemotherapy</topic><topic>Cyclophosphamide</topic><topic>Cyclophosphamide - toxicity</topic><topic>Cytotoxicity</topic><topic>Disease prevention</topic><topic>Doxorubicin</topic><topic>Doxorubicin - toxicity</topic><topic>Drug dosages</topic><topic>Drugs</topic><topic>Female</topic><topic>Fertility</topic><topic>Fertility - drug effects</topic><topic>Fertility Preservation</topic><topic>Follicles</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Infertility</topic><topic>Laboratories</topic><topic>Litter</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neonates</topic><topic>Oocytes</topic><topic>Oocytes - drug effects</topic><topic>Ovarian cancer</topic><topic>Ovarian Follicle - drug effects</topic><topic>Ovary - drug effects</topic><topic>Ovary - pathology</topic><topic>Preservation</topic><topic>Protective Agents - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reproductive Medicine</topic><topic>Survival</topic><topic>Tamoxifen</topic><topic>Tamoxifen - analogs & derivatives</topic><topic>Tamoxifen - pharmacology</topic><topic>Toxicants</topic><topic>Vagina</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ting, Alison Y.</creatorcontrib><creatorcontrib>Petroff, Brian K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ting, Alison Y.</au><au>Petroff, Brian K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tamoxifen decreases ovarian follicular loss from experimental toxicant DMBA and chemotherapy agents cyclophosphamide and doxorubicin in the rat</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>27</volume><issue>11</issue><spage>591</spage><epage>597</epage><pages>591-597</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract>Introduction
We serendipitously observed a protective effect of tamoxifen against depletion of ovarian follicles by 7,12-dimethylbenzanthracene (DMBA), a chemical carcinogen, during a cancer prevention study. Such ovarian protection is being sought as an alternative approach to fertility preservation in human cancer patients.
Methods
Rats received tamoxifen (0, 1 mg or 2.5 mg/kg/d) and DMBA (0, 1, 2 mg/kg/wk) or cyclophosphamide (0, 35, 50 mg/kg/wk). Ovarian follicles were quantified and effects on fertility and litter size were tested. Cultured oocytes were exposed to chemotherapy drug doxorubicin, with or without 4-hydroxytamoxifen (4HT).
Results
DMBA and cyclophosphamide decreased the number of primordial and total follicles, and this reduction was prevented by tamoxifen. Cyclophosphamide tended to reduce fertility and lessened neonatal survival. Tamoxifen reversed these defects. Doxorubicin caused oocyte fragmentation which was prevented by 4HT.
Conclusions
Tamoxifen decreases follicle loss and improves reproductive function following exposure to ovarian toxicants including chemotherapy drugs in the female rat.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>20711751</pmid><doi>10.1007/s10815-010-9463-y</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-0468 |
| ispartof | Journal of assisted reproduction and genetics, 2010-11, Vol.27 (11), p.591-597 |
| issn | 1058-0468 1573-7330 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_954616859 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals; PubMed Central |
| subjects | 9,10-Dimethyl-1,2-benzanthracene 9,10-Dimethyl-1,2-benzanthracene - toxicity Animals Antineoplastic Agents - toxicity Cancer Cancer therapies Carcinogens Cells, Cultured Chemotherapy Cyclophosphamide Cyclophosphamide - toxicity Cytotoxicity Disease prevention Doxorubicin Doxorubicin - toxicity Drug dosages Drugs Female Fertility Fertility - drug effects Fertility Preservation Follicles Gynecology Human Genetics Infertility Laboratories Litter Medicine Medicine & Public Health Neonates Oocytes Oocytes - drug effects Ovarian cancer Ovarian Follicle - drug effects Ovary - drug effects Ovary - pathology Preservation Protective Agents - pharmacology Rats Rats, Sprague-Dawley Reproductive Medicine Survival Tamoxifen Tamoxifen - analogs & derivatives Tamoxifen - pharmacology Toxicants Vagina |
| title | Tamoxifen decreases ovarian follicular loss from experimental toxicant DMBA and chemotherapy agents cyclophosphamide and doxorubicin in the rat |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T17%3A14%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tamoxifen%20decreases%20ovarian%20follicular%20loss%20from%20experimental%20toxicant%20DMBA%20and%20chemotherapy%20agents%20cyclophosphamide%20and%20doxorubicin%20in%20the%20rat&rft.jtitle=Journal%20of%20assisted%20reproduction%20and%20genetics&rft.au=Ting,%20Alison%20Y.&rft.date=2010-11-01&rft.volume=27&rft.issue=11&rft.spage=591&rft.epage=597&rft.pages=591-597&rft.issn=1058-0468&rft.eissn=1573-7330&rft_id=info:doi/10.1007/s10815-010-9463-y&rft_dat=%3Cproquest_pubme%3E954616859%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=815321019&rft_id=info:pmid/20711751&rfr_iscdi=true |