Efficacy of periprosthetic erythromycin delivery for wear debris-induced inflammation and osteolysis
Objectives We have reported that oral erythromycin (EM) inhibits periprosthetic tissue inflammation in a group of patients with aseptic loosening. The purpose of this study was to assess the efficacy of local, periprosthetic EM delivery in a rat model. Methods Uncoated Ti pins were press-fit into th...
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| Veröffentlicht in: | Inflammation research 2010-12, Vol.59 (12), p.1091-1097 |
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| creator | Ren, Weiping Zhang, Renwen Hawkins, Monica Shi, Tong Markel, David C |
| description | Objectives We have reported that oral erythromycin (EM) inhibits periprosthetic tissue inflammation in a group of patients with aseptic loosening. The purpose of this study was to assess the efficacy of local, periprosthetic EM delivery in a rat model. Methods Uncoated Ti pins were press-fit into the right tibia of fourteen Sprague-Dawley rats following an intramedullar injection of UHMWPE (ultra high molecular weight polyethylene) particles. Revision surgeries were performed 2 months after the primary surgery. EM was applied to the Peri-Apatite™ (PA) layer of the titanium (Ti) pins. The previously implanted Ti pins were withdrawn and replaced with Ti pins coated either with (n = 7) or without (n = 7) EM. The rats were killed 1 month after “revision surgery”. The EM efficacy was evaluated by (MicroCT) μCT and histology. Results μCT analysis showed that bone volume percentage (BV/TV) was significantly higher in the EM-treated group compared to the untreated group (p < 0.05). Histological analysis showed that EM treatment inhibits UHMWPE particle-induced periprosthetic tissue inflammation compared to the untreated group. Conclusion This study demonstrated that periprosthetic EM delivery reduced periprosthetic inflammation and improved the quality of surrounding bone. |
| doi_str_mv | 10.1007/s00011-010-0229-x |
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The purpose of this study was to assess the efficacy of local, periprosthetic EM delivery in a rat model. Methods Uncoated Ti pins were press-fit into the right tibia of fourteen Sprague-Dawley rats following an intramedullar injection of UHMWPE (ultra high molecular weight polyethylene) particles. Revision surgeries were performed 2 months after the primary surgery. EM was applied to the Peri-Apatite™ (PA) layer of the titanium (Ti) pins. The previously implanted Ti pins were withdrawn and replaced with Ti pins coated either with (n = 7) or without (n = 7) EM. The rats were killed 1 month after “revision surgery”. The EM efficacy was evaluated by (MicroCT) μCT and histology. Results μCT analysis showed that bone volume percentage (BV/TV) was significantly higher in the EM-treated group compared to the untreated group (p < 0.05). Histological analysis showed that EM treatment inhibits UHMWPE particle-induced periprosthetic tissue inflammation compared to the untreated group. Conclusion This study demonstrated that periprosthetic EM delivery reduced periprosthetic inflammation and improved the quality of surrounding bone.</description><identifier>ISSN: 1023-3830</identifier><identifier>EISSN: 1420-908X</identifier><identifier>DOI: 10.1007/s00011-010-0229-x</identifier><identifier>PMID: 20607583</identifier><language>eng</language><publisher>Basel: Basel : SP Birkhäuser Verlag Basel</publisher><subject>Allergology ; Animal model ; Animals ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - therapeutic use ; Biomedical and Life Sciences ; Biomedicine ; Coated Materials, Biocompatible - metabolism ; Dermatology ; erythromycin ; Erythromycin - administration & dosage ; Erythromycin - therapeutic use ; Humans ; Immunology ; Implants, Experimental ; Inflammation - drug therapy ; Inflammation - etiology ; Inflammation - pathology ; Neurology ; Original Research Paper ; Osteolysis ; Osteolysis - drug therapy ; Osteolysis - etiology ; Osteolysis - pathology ; Pharmacology/Toxicology ; Polyethylenes - metabolism ; Prosthesis Failure ; Rats ; Rats, Sprague-Dawley ; Rheumatology ; Tibia - pathology ; Titanium - metabolism ; Wear debris</subject><ispartof>Inflammation research, 2010-12, Vol.59 (12), p.1091-1097</ispartof><rights>Springer Basel AG 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-8f4c4eb816b9ca6463a530f3ac840d1b443b4385cef7b008cd904c309c8e89273</citedby><cites>FETCH-LOGICAL-c426t-8f4c4eb816b9ca6463a530f3ac840d1b443b4385cef7b008cd904c309c8e89273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00011-010-0229-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00011-010-0229-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20607583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ren, Weiping</creatorcontrib><creatorcontrib>Zhang, Renwen</creatorcontrib><creatorcontrib>Hawkins, Monica</creatorcontrib><creatorcontrib>Shi, Tong</creatorcontrib><creatorcontrib>Markel, David C</creatorcontrib><title>Efficacy of periprosthetic erythromycin delivery for wear debris-induced inflammation and osteolysis</title><title>Inflammation research</title><addtitle>Inflamm. Res</addtitle><addtitle>Inflamm Res</addtitle><description>Objectives We have reported that oral erythromycin (EM) inhibits periprosthetic tissue inflammation in a group of patients with aseptic loosening. The purpose of this study was to assess the efficacy of local, periprosthetic EM delivery in a rat model. Methods Uncoated Ti pins were press-fit into the right tibia of fourteen Sprague-Dawley rats following an intramedullar injection of UHMWPE (ultra high molecular weight polyethylene) particles. Revision surgeries were performed 2 months after the primary surgery. EM was applied to the Peri-Apatite™ (PA) layer of the titanium (Ti) pins. The previously implanted Ti pins were withdrawn and replaced with Ti pins coated either with (n = 7) or without (n = 7) EM. The rats were killed 1 month after “revision surgery”. The EM efficacy was evaluated by (MicroCT) μCT and histology. Results μCT analysis showed that bone volume percentage (BV/TV) was significantly higher in the EM-treated group compared to the untreated group (p < 0.05). Histological analysis showed that EM treatment inhibits UHMWPE particle-induced periprosthetic tissue inflammation compared to the untreated group. Conclusion This study demonstrated that periprosthetic EM delivery reduced periprosthetic inflammation and improved the quality of surrounding bone.</description><subject>Allergology</subject><subject>Animal model</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Coated Materials, Biocompatible - metabolism</subject><subject>Dermatology</subject><subject>erythromycin</subject><subject>Erythromycin - administration & dosage</subject><subject>Erythromycin - therapeutic use</subject><subject>Humans</subject><subject>Immunology</subject><subject>Implants, Experimental</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - etiology</subject><subject>Inflammation - pathology</subject><subject>Neurology</subject><subject>Original Research Paper</subject><subject>Osteolysis</subject><subject>Osteolysis - drug therapy</subject><subject>Osteolysis - etiology</subject><subject>Osteolysis - pathology</subject><subject>Pharmacology/Toxicology</subject><subject>Polyethylenes - metabolism</subject><subject>Prosthesis Failure</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rheumatology</subject><subject>Tibia - pathology</subject><subject>Titanium - metabolism</subject><subject>Wear debris</subject><issn>1023-3830</issn><issn>1420-908X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkctu1jAQhS0EoqXwAGwgYsPKML7EsZeoKhepEguoxM5yHLt1lcQ_dlKat2eqFJBYwMrW-DvHOnMIec7gDQPo3lYAYIwCAwqcG3r7gBwzyYEa0N8e4h24oEILOCJPar1GWnPNH5MjDgq6VotjMpzFmLzzW5NjcwglHUquy1VYkm9C2ZarkqfNp7kZwphucNLEXJofwRWc9CVVmuZh9WFo0hxHN01uSXlu3Dw06BPyuNVUn5JH0Y01PLs_T8jF-7Ovpx_p-ecPn07fnVMvuVqojtLL0GumeuOdkkq4VkAUzmsJA-ulFL0UuvUhdj1m8YMB6QUYr4M2vBMn5PXuiyG-r6EudkrVh3F0c8hrtaaViinF4b9kp6Q0HTCD5Ku_yOu8lhljWI07FEpIjhDbIY_bqyVEeyhpcmWzDOxdVXavymJV9q4qe4uaF_fGaz-F4bfiVzcI8B2o-DRfhvLn53-5vtxF0WXrLrEge_GFAxOYhUErOvETvESo_Q</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Ren, Weiping</creator><creator>Zhang, Renwen</creator><creator>Hawkins, Monica</creator><creator>Shi, Tong</creator><creator>Markel, David C</creator><general>Basel : SP Birkhäuser Verlag Basel</general><general>SP Birkhäuser Verlag Basel</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>20101201</creationdate><title>Efficacy of periprosthetic erythromycin delivery for wear debris-induced inflammation and osteolysis</title><author>Ren, Weiping ; Zhang, Renwen ; Hawkins, Monica ; Shi, Tong ; Markel, David C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-8f4c4eb816b9ca6463a530f3ac840d1b443b4385cef7b008cd904c309c8e89273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Allergology</topic><topic>Animal model</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Coated Materials, Biocompatible - metabolism</topic><topic>Dermatology</topic><topic>erythromycin</topic><topic>Erythromycin - administration & dosage</topic><topic>Erythromycin - therapeutic use</topic><topic>Humans</topic><topic>Immunology</topic><topic>Implants, Experimental</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - etiology</topic><topic>Inflammation - pathology</topic><topic>Neurology</topic><topic>Original Research Paper</topic><topic>Osteolysis</topic><topic>Osteolysis - drug therapy</topic><topic>Osteolysis - etiology</topic><topic>Osteolysis - pathology</topic><topic>Pharmacology/Toxicology</topic><topic>Polyethylenes - metabolism</topic><topic>Prosthesis Failure</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rheumatology</topic><topic>Tibia - pathology</topic><topic>Titanium - metabolism</topic><topic>Wear debris</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ren, Weiping</creatorcontrib><creatorcontrib>Zhang, Renwen</creatorcontrib><creatorcontrib>Hawkins, Monica</creatorcontrib><creatorcontrib>Shi, Tong</creatorcontrib><creatorcontrib>Markel, David C</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Inflammation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ren, Weiping</au><au>Zhang, Renwen</au><au>Hawkins, Monica</au><au>Shi, Tong</au><au>Markel, David C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of periprosthetic erythromycin delivery for wear debris-induced inflammation and osteolysis</atitle><jtitle>Inflammation research</jtitle><stitle>Inflamm. Res</stitle><addtitle>Inflamm Res</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>59</volume><issue>12</issue><spage>1091</spage><epage>1097</epage><pages>1091-1097</pages><issn>1023-3830</issn><eissn>1420-908X</eissn><abstract>Objectives We have reported that oral erythromycin (EM) inhibits periprosthetic tissue inflammation in a group of patients with aseptic loosening. The purpose of this study was to assess the efficacy of local, periprosthetic EM delivery in a rat model. Methods Uncoated Ti pins were press-fit into the right tibia of fourteen Sprague-Dawley rats following an intramedullar injection of UHMWPE (ultra high molecular weight polyethylene) particles. Revision surgeries were performed 2 months after the primary surgery. EM was applied to the Peri-Apatite™ (PA) layer of the titanium (Ti) pins. The previously implanted Ti pins were withdrawn and replaced with Ti pins coated either with (n = 7) or without (n = 7) EM. The rats were killed 1 month after “revision surgery”. The EM efficacy was evaluated by (MicroCT) μCT and histology. Results μCT analysis showed that bone volume percentage (BV/TV) was significantly higher in the EM-treated group compared to the untreated group (p < 0.05). Histological analysis showed that EM treatment inhibits UHMWPE particle-induced periprosthetic tissue inflammation compared to the untreated group. Conclusion This study demonstrated that periprosthetic EM delivery reduced periprosthetic inflammation and improved the quality of surrounding bone.</abstract><cop>Basel</cop><pub>Basel : SP Birkhäuser Verlag Basel</pub><pmid>20607583</pmid><doi>10.1007/s00011-010-0229-x</doi><tpages>7</tpages></addata></record> |
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| subjects | Allergology Animal model Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Biomedical and Life Sciences Biomedicine Coated Materials, Biocompatible - metabolism Dermatology erythromycin Erythromycin - administration & dosage Erythromycin - therapeutic use Humans Immunology Implants, Experimental Inflammation - drug therapy Inflammation - etiology Inflammation - pathology Neurology Original Research Paper Osteolysis Osteolysis - drug therapy Osteolysis - etiology Osteolysis - pathology Pharmacology/Toxicology Polyethylenes - metabolism Prosthesis Failure Rats Rats, Sprague-Dawley Rheumatology Tibia - pathology Titanium - metabolism Wear debris |
| title | Efficacy of periprosthetic erythromycin delivery for wear debris-induced inflammation and osteolysis |
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