Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial
Creatine (CR) supplementation is commonly used by athletes. However, its effects on renal function remain controversial. The aim of this study was to evaluate the effects of creatine supplementation on renal function in healthy sedentary males (18–35 years old) submitted to exercise training. A rand...
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| Veröffentlicht in: | European journal of applied physiology 2008-05, Vol.103 (1), p.33-40 |
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| creator | Gualano, Bruno Ugrinowitsch, Carlos Novaes, Rafael Batista Artioli, Guilherme Gianini Shimizu, Maria Heloisa Seguro, Antonio Carlos Harris, Roger Charles Lancha, Antonio Herbert |
| description | Creatine (CR) supplementation is commonly used by athletes. However, its effects on renal function remain controversial. The aim of this study was to evaluate the effects of creatine supplementation on renal function in healthy sedentary males (18–35 years old) submitted to exercise training. A randomized, double-blind, placebo-controlled trial was performed. Subjects (
n
= 18) were randomly allocated to receive treatment with either creatine (CR) (∼10 g day
−1
over 3 months) or placebo (PL) (dextrose). All subjects undertook moderate intensity aerobic training, in three 40-min sessions per week, during 3 months. Serum creatinine, serum and urinary sodium and potassium were determined at baseline and at the end of the study. Cystatin C was assessed prior to training (PRE), after 4 (POST 4) and 12 weeks (POST 12). Cystatin C levels (mg L
−1
) (PRE CR: 0.82 ± 0.09; PL: 0.88 ± 0.07 vs. POST 12 CR: 0.71 ± 0.06; PL: 0.75 ± 0.09,
P
= 0.0001) were decreased over time, suggesting an increase in glomerular filtration rate. Serum creatinine decreased with training in PL but was unchanged with training in CR. No significant differences were observed within or between groups in other parameters investigated. The decrease in cystatin C indicates that high-dose creatine supplementation over 3 months does not provoke any renal dysfunction in healthy males undergoing aerobic training. In addition, the results suggest that moderate aerobic training per se may improve renal function. |
| doi_str_mv | 10.1007/s00421-007-0669-3 |
| format | Article |
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n
= 18) were randomly allocated to receive treatment with either creatine (CR) (∼10 g day
−1
over 3 months) or placebo (PL) (dextrose). All subjects undertook moderate intensity aerobic training, in three 40-min sessions per week, during 3 months. Serum creatinine, serum and urinary sodium and potassium were determined at baseline and at the end of the study. Cystatin C was assessed prior to training (PRE), after 4 (POST 4) and 12 weeks (POST 12). Cystatin C levels (mg L
−1
) (PRE CR: 0.82 ± 0.09; PL: 0.88 ± 0.07 vs. POST 12 CR: 0.71 ± 0.06; PL: 0.75 ± 0.09,
P
= 0.0001) were decreased over time, suggesting an increase in glomerular filtration rate. Serum creatinine decreased with training in PL but was unchanged with training in CR. No significant differences were observed within or between groups in other parameters investigated. The decrease in cystatin C indicates that high-dose creatine supplementation over 3 months does not provoke any renal dysfunction in healthy males undergoing aerobic training. In addition, the results suggest that moderate aerobic training per se may improve renal function.</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-007-0669-3</identifier><identifier>PMID: 18188581</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Aerobics ; Biomedical and Life Sciences ; Biomedicine ; Clinical trials ; Creatine - administration & dosage ; Creatine - pharmacology ; Creatinine ; Creatinine - blood ; Dietary Supplements ; Dose-Response Relationship, Drug ; Double-Blind Method ; Exercise ; Exercise - physiology ; Glomerular Filtration Rate - drug effects ; Glomerular Filtration Rate - physiology ; Human Physiology ; Humans ; Kidney - drug effects ; Kidney - physiology ; Kidneys ; Male ; Males ; Occupational Medicine/Industrial Medicine ; Original Article ; Oxygen Consumption - physiology ; Physical fitness ; Potassium - blood ; Potassium - urine ; Sodium - blood ; Sodium - urine ; Sports Medicine</subject><ispartof>European journal of applied physiology, 2008-05, Vol.103 (1), p.33-40</ispartof><rights>Springer-Verlag 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-5e8f787d5ac18c82f48d5a2d6894183f6d3eb7b23ae71a29c035cada1b3ce5693</citedby><cites>FETCH-LOGICAL-c401t-5e8f787d5ac18c82f48d5a2d6894183f6d3eb7b23ae71a29c035cada1b3ce5693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00421-007-0669-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00421-007-0669-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18188581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gualano, Bruno</creatorcontrib><creatorcontrib>Ugrinowitsch, Carlos</creatorcontrib><creatorcontrib>Novaes, Rafael Batista</creatorcontrib><creatorcontrib>Artioli, Guilherme Gianini</creatorcontrib><creatorcontrib>Shimizu, Maria Heloisa</creatorcontrib><creatorcontrib>Seguro, Antonio Carlos</creatorcontrib><creatorcontrib>Harris, Roger Charles</creatorcontrib><creatorcontrib>Lancha, Antonio Herbert</creatorcontrib><title>Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>Eur J Appl Physiol</addtitle><description>Creatine (CR) supplementation is commonly used by athletes. However, its effects on renal function remain controversial. The aim of this study was to evaluate the effects of creatine supplementation on renal function in healthy sedentary males (18–35 years old) submitted to exercise training. A randomized, double-blind, placebo-controlled trial was performed. Subjects (
n
= 18) were randomly allocated to receive treatment with either creatine (CR) (∼10 g day
−1
over 3 months) or placebo (PL) (dextrose). All subjects undertook moderate intensity aerobic training, in three 40-min sessions per week, during 3 months. Serum creatinine, serum and urinary sodium and potassium were determined at baseline and at the end of the study. Cystatin C was assessed prior to training (PRE), after 4 (POST 4) and 12 weeks (POST 12). Cystatin C levels (mg L
−1
) (PRE CR: 0.82 ± 0.09; PL: 0.88 ± 0.07 vs. POST 12 CR: 0.71 ± 0.06; PL: 0.75 ± 0.09,
P
= 0.0001) were decreased over time, suggesting an increase in glomerular filtration rate. Serum creatinine decreased with training in PL but was unchanged with training in CR. No significant differences were observed within or between groups in other parameters investigated. The decrease in cystatin C indicates that high-dose creatine supplementation over 3 months does not provoke any renal dysfunction in healthy males undergoing aerobic training. In addition, the results suggest that moderate aerobic training per se may improve renal function.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aerobics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Clinical trials</subject><subject>Creatine - administration & dosage</subject><subject>Creatine - pharmacology</subject><subject>Creatinine</subject><subject>Creatinine - blood</subject><subject>Dietary Supplements</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Glomerular Filtration Rate - drug effects</subject><subject>Glomerular Filtration Rate - physiology</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Kidney - drug effects</subject><subject>Kidney - physiology</subject><subject>Kidneys</subject><subject>Male</subject><subject>Males</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Oxygen Consumption - physiology</subject><subject>Physical fitness</subject><subject>Potassium - blood</subject><subject>Potassium - urine</subject><subject>Sodium - blood</subject><subject>Sodium - urine</subject><subject>Sports Medicine</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc2KFTEQhYMozo8-gBsJLnRjNJWku9Ozk2FGhQE3ug7ppCI9pJM26V7o05vLvTggKARyKvXVKcgh5AXwd8D58L5yrgSwJhnv-5HJR-QclBxZL8Xw-I-G8Yxc1HrPOdcC9FNyBhq07jSck-0mBHRbpTlQV9Buc0Ja93WNuGDaWp0TbadgspGGPbnDyxW1tNjk8zL_Qv-W-rxPEdkU59SqNVqHU2Yup63kGNFT1zqzaw5bmW18Rp4EGys-P92X5NvtzdfrT-zuy8fP1x_umFMcNtahDoMefGcdaKdFULpp4Xs9KtAy9F7iNExCWhzAitFx2TnrLUzSYdeP8pK8OfquJf_YsW5mmavDGG3CvFczdqoHJZRq5Ov_kgMXeuw63sBXf4H3eS_tb6oRXEpQvewbBEfIlVxrwWDWMi-2_DTAzSE5c0zOHOQhOSPbzMuT8T4t6B8mTlE1QByB2lrpO5aHzf92_Q1r7aSI</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Gualano, Bruno</creator><creator>Ugrinowitsch, Carlos</creator><creator>Novaes, Rafael Batista</creator><creator>Artioli, Guilherme Gianini</creator><creator>Shimizu, Maria Heloisa</creator><creator>Seguro, Antonio Carlos</creator><creator>Harris, Roger Charles</creator><creator>Lancha, Antonio Herbert</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TS</scope></search><sort><creationdate>20080501</creationdate><title>Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial</title><author>Gualano, Bruno ; Ugrinowitsch, Carlos ; Novaes, Rafael Batista ; Artioli, Guilherme Gianini ; Shimizu, Maria Heloisa ; Seguro, Antonio Carlos ; Harris, Roger Charles ; Lancha, Antonio Herbert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-5e8f787d5ac18c82f48d5a2d6894183f6d3eb7b23ae71a29c035cada1b3ce5693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aerobics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Clinical trials</topic><topic>Creatine - administration & dosage</topic><topic>Creatine - pharmacology</topic><topic>Creatinine</topic><topic>Creatinine - blood</topic><topic>Dietary Supplements</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Glomerular Filtration Rate - drug effects</topic><topic>Glomerular Filtration Rate - physiology</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Kidney - drug effects</topic><topic>Kidney - physiology</topic><topic>Kidneys</topic><topic>Male</topic><topic>Males</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Oxygen Consumption - physiology</topic><topic>Physical fitness</topic><topic>Potassium - blood</topic><topic>Potassium - urine</topic><topic>Sodium - blood</topic><topic>Sodium - urine</topic><topic>Sports Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gualano, Bruno</creatorcontrib><creatorcontrib>Ugrinowitsch, Carlos</creatorcontrib><creatorcontrib>Novaes, Rafael Batista</creatorcontrib><creatorcontrib>Artioli, Guilherme Gianini</creatorcontrib><creatorcontrib>Shimizu, Maria Heloisa</creatorcontrib><creatorcontrib>Seguro, Antonio Carlos</creatorcontrib><creatorcontrib>Harris, Roger Charles</creatorcontrib><creatorcontrib>Lancha, Antonio Herbert</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gualano, Bruno</au><au>Ugrinowitsch, Carlos</au><au>Novaes, Rafael Batista</au><au>Artioli, Guilherme Gianini</au><au>Shimizu, Maria Heloisa</au><au>Seguro, Antonio Carlos</au><au>Harris, Roger Charles</au><au>Lancha, Antonio Herbert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>103</volume><issue>1</issue><spage>33</spage><epage>40</epage><pages>33-40</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>Creatine (CR) supplementation is commonly used by athletes. However, its effects on renal function remain controversial. The aim of this study was to evaluate the effects of creatine supplementation on renal function in healthy sedentary males (18–35 years old) submitted to exercise training. A randomized, double-blind, placebo-controlled trial was performed. Subjects (
n
= 18) were randomly allocated to receive treatment with either creatine (CR) (∼10 g day
−1
over 3 months) or placebo (PL) (dextrose). All subjects undertook moderate intensity aerobic training, in three 40-min sessions per week, during 3 months. Serum creatinine, serum and urinary sodium and potassium were determined at baseline and at the end of the study. Cystatin C was assessed prior to training (PRE), after 4 (POST 4) and 12 weeks (POST 12). Cystatin C levels (mg L
−1
) (PRE CR: 0.82 ± 0.09; PL: 0.88 ± 0.07 vs. POST 12 CR: 0.71 ± 0.06; PL: 0.75 ± 0.09,
P
= 0.0001) were decreased over time, suggesting an increase in glomerular filtration rate. Serum creatinine decreased with training in PL but was unchanged with training in CR. No significant differences were observed within or between groups in other parameters investigated. The decrease in cystatin C indicates that high-dose creatine supplementation over 3 months does not provoke any renal dysfunction in healthy males undergoing aerobic training. In addition, the results suggest that moderate aerobic training per se may improve renal function.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>18188581</pmid><doi>10.1007/s00421-007-0669-3</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult Aerobics Biomedical and Life Sciences Biomedicine Clinical trials Creatine - administration & dosage Creatine - pharmacology Creatinine Creatinine - blood Dietary Supplements Dose-Response Relationship, Drug Double-Blind Method Exercise Exercise - physiology Glomerular Filtration Rate - drug effects Glomerular Filtration Rate - physiology Human Physiology Humans Kidney - drug effects Kidney - physiology Kidneys Male Males Occupational Medicine/Industrial Medicine Original Article Oxygen Consumption - physiology Physical fitness Potassium - blood Potassium - urine Sodium - blood Sodium - urine Sports Medicine |
| title | Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial |
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