Chronic activation of the D2 autoreceptor inhibits both glutamate and dopamine synapse formation and alters the intrinsic properties of mesencephalic dopamine neurons in vitro

Dysfunctional dopamine (DA)‐mediated signaling is implicated in several diseases including Parkinson’s disease, schizophrenia and attention deficit and hyperactivity disorder. Chronic treatment with DA receptor agonists or antagonists is often used in pharmacotherapy, but the consequences of these t...

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Veröffentlicht in:	The European journal of neuroscience 2010-11, Vol.32 (9), p.1433-1441
Hauptverfasser:	Fasano, C., Kortleven, C., Trudeau, L.-E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antagonists Attention deficit hyperactivity disorder autapse Cells, Cultured Dopamine - metabolism Dopamine Agonists - metabolism Dopamine D2 receptors Dopamine receptors Firing rate Glutamatergic transmission Glutamic acid Glutamic Acid - metabolism Hyperpolarization Mental disorders mesencephalon Mesencephalon - cytology Mesencephalon - metabolism Mice Mice, Transgenic mouse Movement disorders Nervous system Neurodegenerative diseases Neurogenesis - physiology Neurological diseases Neurons Neurons - cytology Neurons - metabolism Parkinson's disease Patch-Clamp Techniques Phosphorylation Plasticity (functional) Presynapse primary culture Protein kinase quinpirole Quinpirole - metabolism Receptor mechanisms Receptors, Dopamine D2 - metabolism Schizophrenia Structure-function relationships Synapses Synapses - physiology Synaptogenesis Tyrosine 3-monooxygenase Tyrosine 3-Monooxygenase - metabolism VGLUT2 VMAT2
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