Vitamin E supplementation in rats with experimental diabetes mellitus: analysis of myosin-V and nNOS immunoreactive myenteric neurons from terminal ileum
The effect of vitamin E (1 g/kg body weight) supplementation on myosin-V and neuronal nitric oxide synthase (nNOS) immunoreactive myenteric neurons from the ileum of diabetic rats was investigated in the present study. Forty animals were divided into the following groups: normoglycemics (N), normogl...
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| Veröffentlicht in: | Journal of molecular histology 2008-12, Vol.39 (6), p.595-603 |
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| creator | Pereira, Renata Virginia Fernandes de Miranda-Neto, Marcílio Hubner da Silva Souza, Ivan Domicio Zanoni, Jacqueline Nelisis |
| description | The effect of vitamin E (1 g/kg body weight) supplementation on myosin-V and neuronal nitric oxide synthase (nNOS) immunoreactive myenteric neurons from the ileum of diabetic rats was investigated in the present study. Forty animals were divided into the following groups: normoglycemics (N), normoglycemics treated with vitamin E (NE), diabetics (D), and diabetics treated with vitamin E (DE). Quantitative and morphometric analyses were performed. The area of the tertiary plexus was also determined. Diabetes produced a 24% reduction in the number of myosin-V neurons in group D compared with group N, an effect that was accompanied by an increase in the tertiary plexus area (
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| doi_str_mv | 10.1007/s10735-008-9200-3 |
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P
< 0.05). Neuronal density was 27% higher in group NE than group N (
P
< 0.05). Nitrergic neuronal density was not altered as a consequence of either diabetes or vitamin E treatment. Myosin-V and nNOS immunoreactive neuronal cell body area increased significantly in group NE. The area of myosin-V and nNOS myenteric neurons also increased in group D. Vitamin E treatment (group DE) increased only the size of nitrergic neurons. The present results suggest that vitamin E elicited a neuroprotective and neurotrophic effect on the natural aging process, but with regard to diabetes, vitamin E supplementation exerted a neurotrophic effect only on nitrergic neurons.</description><identifier>ISSN: 1567-2379</identifier><identifier>EISSN: 1567-2387</identifier><identifier>DOI: 10.1007/s10735-008-9200-3</identifier><identifier>PMID: 18953659</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animals ; Antioxidants - administration & dosage ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Developmental Biology ; Diabetes Mellitus, Experimental - metabolism ; Dietary Supplements ; Humans ; Ileum - cytology ; Ileum - innervation ; Ileum - metabolism ; Life Sciences ; Male ; Myenteric Plexus - cytology ; Myosin Type V - metabolism ; Neurons - cytology ; Neurons - metabolism ; Neuroprotective Agents - administration & dosage ; Nitric Oxide Synthase Type I - metabolism ; Original Paper ; Rats ; Rats, Wistar ; Vitamin E - administration & dosage</subject><ispartof>Journal of molecular histology, 2008-12, Vol.39 (6), p.595-603</ispartof><rights>Springer Science+Business Media B.V. 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-18f9994c5b7156616e24e511d494f0a6c0e5cbe2664c9fd6470027dd7db11c3c3</citedby><cites>FETCH-LOGICAL-c401t-18f9994c5b7156616e24e511d494f0a6c0e5cbe2664c9fd6470027dd7db11c3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10735-008-9200-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10735-008-9200-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27926,27927,41490,42559,51321</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18953659$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pereira, Renata Virginia Fernandes</creatorcontrib><creatorcontrib>de Miranda-Neto, Marcílio Hubner</creatorcontrib><creatorcontrib>da Silva Souza, Ivan Domicio</creatorcontrib><creatorcontrib>Zanoni, Jacqueline Nelisis</creatorcontrib><title>Vitamin E supplementation in rats with experimental diabetes mellitus: analysis of myosin-V and nNOS immunoreactive myenteric neurons from terminal ileum</title><title>Journal of molecular histology</title><addtitle>J Mol Hist</addtitle><addtitle>J Mol Histol</addtitle><description>The effect of vitamin E (1 g/kg body weight) supplementation on myosin-V and neuronal nitric oxide synthase (nNOS) immunoreactive myenteric neurons from the ileum of diabetic rats was investigated in the present study. Forty animals were divided into the following groups: normoglycemics (N), normoglycemics treated with vitamin E (NE), diabetics (D), and diabetics treated with vitamin E (DE). Quantitative and morphometric analyses were performed. The area of the tertiary plexus was also determined. Diabetes produced a 24% reduction in the number of myosin-V neurons in group D compared with group N, an effect that was accompanied by an increase in the tertiary plexus area (
P
< 0.05). Neuronal density was 27% higher in group NE than group N (
P
< 0.05). Nitrergic neuronal density was not altered as a consequence of either diabetes or vitamin E treatment. Myosin-V and nNOS immunoreactive neuronal cell body area increased significantly in group NE. The area of myosin-V and nNOS myenteric neurons also increased in group D. Vitamin E treatment (group DE) increased only the size of nitrergic neurons. The present results suggest that vitamin E elicited a neuroprotective and neurotrophic effect on the natural aging process, but with regard to diabetes, vitamin E supplementation exerted a neurotrophic effect only on nitrergic neurons.</description><subject>Animals</subject><subject>Antioxidants - administration & dosage</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Developmental Biology</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Dietary Supplements</subject><subject>Humans</subject><subject>Ileum - cytology</subject><subject>Ileum - innervation</subject><subject>Ileum - metabolism</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Myenteric Plexus - cytology</subject><subject>Myosin Type V - metabolism</subject><subject>Neurons - cytology</subject><subject>Neurons - metabolism</subject><subject>Neuroprotective Agents - administration & dosage</subject><subject>Nitric Oxide Synthase Type I - metabolism</subject><subject>Original Paper</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Vitamin E - administration & dosage</subject><issn>1567-2379</issn><issn>1567-2387</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1u1TAQhSMEoqXwAGyQxQJWAdvxT8yuqsqPVNEF0K3lOBNwFTvBdoD7KLwtU-4VlZBgZWvmm2OfOU3zmNEXjFL9sjCqO9lS2reGU9p2d5pjJpVuedfru3_u2hw1D0q5ppT3Spj7zRHrjeyUNMfNz6tQXQyJnJOyresMEVJ1NSyJYDG7Wsj3UL8Q-LFCDr-bMxmDG6BCIRHmOdStvCIuuXlXQiHLROJuKSG1V1gcSXp_-YGEGLe0ZHC-hm-AAOqgnCcJtrykQqa8RIIl_Anqhxm2-LC5N7m5wKPDedJ8en3-8exte3H55t3Z6UXrBWW1Zf1kjBFeDhrtKqaAC5CMjcKIiTrlKUg_AFdKeDONSmhcgx5HPQ6M-c53J83zve6al68blGpjKB6NuQTLVqyRQjHaC4nks_-SymjDJdcIPv0LvF62jM6K5VwywQ1TCLE95PNSSobJrrhgl3eWUXsTr93HazFeexOv7XDmyUF4GyKMtxOHPBHge6BgK32GfPvyv1V_AQXQspc</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Pereira, Renata Virginia Fernandes</creator><creator>de Miranda-Neto, Marcílio Hubner</creator><creator>da Silva Souza, Ivan Domicio</creator><creator>Zanoni, Jacqueline Nelisis</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20081201</creationdate><title>Vitamin E supplementation in rats with experimental diabetes mellitus: analysis of myosin-V and nNOS immunoreactive myenteric neurons from terminal ileum</title><author>Pereira, Renata Virginia Fernandes ; de Miranda-Neto, Marcílio Hubner ; da Silva Souza, Ivan Domicio ; Zanoni, Jacqueline Nelisis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-18f9994c5b7156616e24e511d494f0a6c0e5cbe2664c9fd6470027dd7db11c3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Antioxidants - administration & dosage</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Developmental Biology</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Dietary Supplements</topic><topic>Humans</topic><topic>Ileum - cytology</topic><topic>Ileum - innervation</topic><topic>Ileum - metabolism</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Myenteric Plexus - cytology</topic><topic>Myosin Type V - metabolism</topic><topic>Neurons - cytology</topic><topic>Neurons - metabolism</topic><topic>Neuroprotective Agents - administration & dosage</topic><topic>Nitric Oxide Synthase Type I - metabolism</topic><topic>Original Paper</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Vitamin E - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pereira, Renata Virginia Fernandes</creatorcontrib><creatorcontrib>de Miranda-Neto, Marcílio Hubner</creatorcontrib><creatorcontrib>da Silva Souza, Ivan Domicio</creatorcontrib><creatorcontrib>Zanoni, Jacqueline Nelisis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular histology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pereira, Renata Virginia Fernandes</au><au>de Miranda-Neto, Marcílio Hubner</au><au>da Silva Souza, Ivan Domicio</au><au>Zanoni, Jacqueline Nelisis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin E supplementation in rats with experimental diabetes mellitus: analysis of myosin-V and nNOS immunoreactive myenteric neurons from terminal ileum</atitle><jtitle>Journal of molecular histology</jtitle><stitle>J Mol Hist</stitle><addtitle>J Mol Histol</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>39</volume><issue>6</issue><spage>595</spage><epage>603</epage><pages>595-603</pages><issn>1567-2379</issn><eissn>1567-2387</eissn><abstract>The effect of vitamin E (1 g/kg body weight) supplementation on myosin-V and neuronal nitric oxide synthase (nNOS) immunoreactive myenteric neurons from the ileum of diabetic rats was investigated in the present study. Forty animals were divided into the following groups: normoglycemics (N), normoglycemics treated with vitamin E (NE), diabetics (D), and diabetics treated with vitamin E (DE). Quantitative and morphometric analyses were performed. The area of the tertiary plexus was also determined. Diabetes produced a 24% reduction in the number of myosin-V neurons in group D compared with group N, an effect that was accompanied by an increase in the tertiary plexus area (
P
< 0.05). Neuronal density was 27% higher in group NE than group N (
P
< 0.05). Nitrergic neuronal density was not altered as a consequence of either diabetes or vitamin E treatment. Myosin-V and nNOS immunoreactive neuronal cell body area increased significantly in group NE. The area of myosin-V and nNOS myenteric neurons also increased in group D. Vitamin E treatment (group DE) increased only the size of nitrergic neurons. The present results suggest that vitamin E elicited a neuroprotective and neurotrophic effect on the natural aging process, but with regard to diabetes, vitamin E supplementation exerted a neurotrophic effect only on nitrergic neurons.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>18953659</pmid><doi>10.1007/s10735-008-9200-3</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Antioxidants - administration & dosage Biomedical and Life Sciences Biomedicine Cell Biology Developmental Biology Diabetes Mellitus, Experimental - metabolism Dietary Supplements Humans Ileum - cytology Ileum - innervation Ileum - metabolism Life Sciences Male Myenteric Plexus - cytology Myosin Type V - metabolism Neurons - cytology Neurons - metabolism Neuroprotective Agents - administration & dosage Nitric Oxide Synthase Type I - metabolism Original Paper Rats Rats, Wistar Vitamin E - administration & dosage |
| title | Vitamin E supplementation in rats with experimental diabetes mellitus: analysis of myosin-V and nNOS immunoreactive myenteric neurons from terminal ileum |
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