Placental histology related to fetal brain sonography
Background Chronic hypoxia and inflammatory processes can induce placental disturbances that may indirectly lead to perinatal brain injury. Objective To study histological features of the placenta in relation to echogenicity changes in the periventricular white matter, ventricular system and basal g...
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| Veröffentlicht in: | Archives of disease in childhood. Fetal and neonatal edition 2011-01, Vol.96 (1), p.F53-F58 |
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| container_title | Archives of disease in childhood. Fetal and neonatal edition |
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| creator | Rosier-van Dunné, F M F van Wezel-Meijler, G Kaschula, R O C Wranz, P A B Odendaal, H J de Vries, J I P |
| description | Background Chronic hypoxia and inflammatory processes can induce placental disturbances that may indirectly lead to perinatal brain injury. Objective To study histological features of the placenta in relation to echogenicity changes in the periventricular white matter, ventricular system and basal ganglia/thalami of the fetal brain. Design Prospective study of 77 fetuses between 26 and 34 weeks gestational age with their placentas. The pregnancies were complicated by hypertensive disorders (n=42) or preterm labour (n=35). Results Of the placentas 79% showed uteroplacental hypoperfusion, inflammation or a combination. Transvaginal ultrasound examination of the brain revealed echogenicity changes in 73% of the fetuses (44 mild, 29 moderate). Moderate brain echogenicity changes (periventricular echodensity (PVE) grade IB: increased echogenicity brighter than choroid plexus, intraventricular echodensity (IVE) grade II and III: echodensity filling ventricle respectively |
| doi_str_mv | 10.1136/adc.2009.181198 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_954609298</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>821193594</sourcerecordid><originalsourceid>FETCH-LOGICAL-b429t-d93bf721477d554ae7acce06e942b8084ec7ec8087cb27b36c87ebee2b0f30333</originalsourceid><addsrcrecordid>eNqFkE1PGzEQhi1UVCjtmVu1Ug-VkDaMv9b2EUWUIhDtgeZq2d5ZSLpZB3sjNf8eR0s5cOE0rzTPzGgeQk4pzCjlzblrw4wBmBnVlBp9QI6paHTNQLIPJXNpamaMPiKfcl4BAFVKfSRHDBRvBFXHRP7uXcBhdH31uMxj7OPDrkrYuxHbaoxVh_uWT245VDkO8SG5zePuMznsXJ_xy0s9IX9-XN7Pf9a3v66u5xe3tRfMjHVruO8Uo0KpVkrhULkQEBo0gnkNWmBQGEpQwTPleRO0Qo_IPHQcOOcn5Pu0d5Pi0xbzaNfLHLDv3YBxm62RogHDjH6X1Kz4KTpEIb-9IVdxm4byhqVKgxBUGlmo84kKKeacsLObtFy7tLMU7F69LertXr2d1JeJry97t36N7Sv_33UB6gkonvHfa9-lv7ZRXEl7t5jbOb2HBYgbuyj82cT79erd689JPJl5</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1780441595</pqid></control><display><type>article</type><title>Placental histology related to fetal brain sonography</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><creator>Rosier-van Dunné, F M F ; van Wezel-Meijler, G ; Kaschula, R O C ; Wranz, P A B ; Odendaal, H J ; de Vries, J I P</creator><creatorcontrib>Rosier-van Dunné, F M F ; van Wezel-Meijler, G ; Kaschula, R O C ; Wranz, P A B ; Odendaal, H J ; de Vries, J I P</creatorcontrib><description>Background Chronic hypoxia and inflammatory processes can induce placental disturbances that may indirectly lead to perinatal brain injury. Objective To study histological features of the placenta in relation to echogenicity changes in the periventricular white matter, ventricular system and basal ganglia/thalami of the fetal brain. Design Prospective study of 77 fetuses between 26 and 34 weeks gestational age with their placentas. The pregnancies were complicated by hypertensive disorders (n=42) or preterm labour (n=35). Results Of the placentas 79% showed uteroplacental hypoperfusion, inflammation or a combination. Transvaginal ultrasound examination of the brain revealed echogenicity changes in 73% of the fetuses (44 mild, 29 moderate). Moderate brain echogenicity changes (periventricular echodensity (PVE) grade IB: increased echogenicity brighter than choroid plexus, intraventricular echodensity (IVE) grade II and III: echodensity filling ventricle respectively <50% and ≥50%; basal ganglia/thalamic echodensity (BGTE): locally increased echogenicity within basal ganglia/thalami) were equally distributed over cases with uteroplacental hypoperfusion and inflammatory features in the placenta. PVE grade IB was always associated with placental pathology. The sensitivity and negative predictive value of placental pathology for moderate echogenicity changes were high (0.91 and 0.88, respectively), while the specificity and positive predictive value were low (0.27 and 0.34, respectively). Conclusions Normal placental histology predicted no or mild echogenicity changes, supporting the view that the latter are physiological. Placental pathology was always present in cases with grade IB PVE, presumed to represent mild or early forms of white matter injury. Both uteroplacental hypoperfusion and inflammatory features were seen in placentas from pregnancies with hypertensive disorders.</description><identifier>ISSN: 1359-2998</identifier><identifier>EISSN: 1468-2052</identifier><identifier>DOI: 10.1136/adc.2009.181198</identifier><identifier>PMID: 20736417</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Brain - embryology ; Brain Injuries - diagnostic imaging ; Brain Injuries - pathology ; Echoencephalography - methods ; Epidemiologic Methods ; Female ; Gestational Age ; Histology ; Humans ; Hypertension - pathology ; Hypertension - physiopathology ; Hypoxia ; Obstetric Labor, Premature - pathology ; Pathology ; Placenta - pathology ; Placental Circulation ; Pregnancy ; Pregnancy Complications, Cardiovascular - pathology ; Pregnancy Complications, Cardiovascular - physiopathology ; Ultrasonography, Prenatal - methods ; Umbilical Cord - pathology</subject><ispartof>Archives of disease in childhood. Fetal and neonatal edition, 2011-01, Vol.96 (1), p.F53-F58</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2010 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b429t-d93bf721477d554ae7acce06e942b8084ec7ec8087cb27b36c87ebee2b0f30333</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://fn.bmj.com/content/96/1/F53.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://fn.bmj.com/content/96/1/F53.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3183,23550,27901,27902,77569,77600</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20736417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosier-van Dunné, F M F</creatorcontrib><creatorcontrib>van Wezel-Meijler, G</creatorcontrib><creatorcontrib>Kaschula, R O C</creatorcontrib><creatorcontrib>Wranz, P A B</creatorcontrib><creatorcontrib>Odendaal, H J</creatorcontrib><creatorcontrib>de Vries, J I P</creatorcontrib><title>Placental histology related to fetal brain sonography</title><title>Archives of disease in childhood. Fetal and neonatal edition</title><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><description>Background Chronic hypoxia and inflammatory processes can induce placental disturbances that may indirectly lead to perinatal brain injury. Objective To study histological features of the placenta in relation to echogenicity changes in the periventricular white matter, ventricular system and basal ganglia/thalami of the fetal brain. Design Prospective study of 77 fetuses between 26 and 34 weeks gestational age with their placentas. The pregnancies were complicated by hypertensive disorders (n=42) or preterm labour (n=35). Results Of the placentas 79% showed uteroplacental hypoperfusion, inflammation or a combination. Transvaginal ultrasound examination of the brain revealed echogenicity changes in 73% of the fetuses (44 mild, 29 moderate). Moderate brain echogenicity changes (periventricular echodensity (PVE) grade IB: increased echogenicity brighter than choroid plexus, intraventricular echodensity (IVE) grade II and III: echodensity filling ventricle respectively <50% and ≥50%; basal ganglia/thalamic echodensity (BGTE): locally increased echogenicity within basal ganglia/thalami) were equally distributed over cases with uteroplacental hypoperfusion and inflammatory features in the placenta. PVE grade IB was always associated with placental pathology. The sensitivity and negative predictive value of placental pathology for moderate echogenicity changes were high (0.91 and 0.88, respectively), while the specificity and positive predictive value were low (0.27 and 0.34, respectively). Conclusions Normal placental histology predicted no or mild echogenicity changes, supporting the view that the latter are physiological. Placental pathology was always present in cases with grade IB PVE, presumed to represent mild or early forms of white matter injury. Both uteroplacental hypoperfusion and inflammatory features were seen in placentas from pregnancies with hypertensive disorders.</description><subject>Brain - embryology</subject><subject>Brain Injuries - diagnostic imaging</subject><subject>Brain Injuries - pathology</subject><subject>Echoencephalography - methods</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Histology</subject><subject>Humans</subject><subject>Hypertension - pathology</subject><subject>Hypertension - physiopathology</subject><subject>Hypoxia</subject><subject>Obstetric Labor, Premature - pathology</subject><subject>Pathology</subject><subject>Placenta - pathology</subject><subject>Placental Circulation</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Cardiovascular - pathology</subject><subject>Pregnancy Complications, Cardiovascular - physiopathology</subject><subject>Ultrasonography, Prenatal - methods</subject><subject>Umbilical Cord - pathology</subject><issn>1359-2998</issn><issn>1468-2052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkE1PGzEQhi1UVCjtmVu1Ug-VkDaMv9b2EUWUIhDtgeZq2d5ZSLpZB3sjNf8eR0s5cOE0rzTPzGgeQk4pzCjlzblrw4wBmBnVlBp9QI6paHTNQLIPJXNpamaMPiKfcl4BAFVKfSRHDBRvBFXHRP7uXcBhdH31uMxj7OPDrkrYuxHbaoxVh_uWT245VDkO8SG5zePuMznsXJ_xy0s9IX9-XN7Pf9a3v66u5xe3tRfMjHVruO8Uo0KpVkrhULkQEBo0gnkNWmBQGEpQwTPleRO0Qo_IPHQcOOcn5Pu0d5Pi0xbzaNfLHLDv3YBxm62RogHDjH6X1Kz4KTpEIb-9IVdxm4byhqVKgxBUGlmo84kKKeacsLObtFy7tLMU7F69LertXr2d1JeJry97t36N7Sv_33UB6gkonvHfa9-lv7ZRXEl7t5jbOb2HBYgbuyj82cT79erd689JPJl5</recordid><startdate>201101</startdate><enddate>201101</enddate><creator>Rosier-van Dunné, F M F</creator><creator>van Wezel-Meijler, G</creator><creator>Kaschula, R O C</creator><creator>Wranz, P A B</creator><creator>Odendaal, H J</creator><creator>de Vries, J I P</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201101</creationdate><title>Placental histology related to fetal brain sonography</title><author>Rosier-van Dunné, F M F ; van Wezel-Meijler, G ; Kaschula, R O C ; Wranz, P A B ; Odendaal, H J ; de Vries, J I P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b429t-d93bf721477d554ae7acce06e942b8084ec7ec8087cb27b36c87ebee2b0f30333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Brain - embryology</topic><topic>Brain Injuries - diagnostic imaging</topic><topic>Brain Injuries - pathology</topic><topic>Echoencephalography - methods</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Histology</topic><topic>Humans</topic><topic>Hypertension - pathology</topic><topic>Hypertension - physiopathology</topic><topic>Hypoxia</topic><topic>Obstetric Labor, Premature - pathology</topic><topic>Pathology</topic><topic>Placenta - pathology</topic><topic>Placental Circulation</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Cardiovascular - pathology</topic><topic>Pregnancy Complications, Cardiovascular - physiopathology</topic><topic>Ultrasonography, Prenatal - methods</topic><topic>Umbilical Cord - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosier-van Dunné, F M F</creatorcontrib><creatorcontrib>van Wezel-Meijler, G</creatorcontrib><creatorcontrib>Kaschula, R O C</creatorcontrib><creatorcontrib>Wranz, P A B</creatorcontrib><creatorcontrib>Odendaal, H J</creatorcontrib><creatorcontrib>de Vries, J I P</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosier-van Dunné, F M F</au><au>van Wezel-Meijler, G</au><au>Kaschula, R O C</au><au>Wranz, P A B</au><au>Odendaal, H J</au><au>de Vries, J I P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Placental histology related to fetal brain sonography</atitle><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><date>2011-01</date><risdate>2011</risdate><volume>96</volume><issue>1</issue><spage>F53</spage><epage>F58</epage><pages>F53-F58</pages><issn>1359-2998</issn><eissn>1468-2052</eissn><abstract>Background Chronic hypoxia and inflammatory processes can induce placental disturbances that may indirectly lead to perinatal brain injury. Objective To study histological features of the placenta in relation to echogenicity changes in the periventricular white matter, ventricular system and basal ganglia/thalami of the fetal brain. Design Prospective study of 77 fetuses between 26 and 34 weeks gestational age with their placentas. The pregnancies were complicated by hypertensive disorders (n=42) or preterm labour (n=35). Results Of the placentas 79% showed uteroplacental hypoperfusion, inflammation or a combination. Transvaginal ultrasound examination of the brain revealed echogenicity changes in 73% of the fetuses (44 mild, 29 moderate). Moderate brain echogenicity changes (periventricular echodensity (PVE) grade IB: increased echogenicity brighter than choroid plexus, intraventricular echodensity (IVE) grade II and III: echodensity filling ventricle respectively <50% and ≥50%; basal ganglia/thalamic echodensity (BGTE): locally increased echogenicity within basal ganglia/thalami) were equally distributed over cases with uteroplacental hypoperfusion and inflammatory features in the placenta. PVE grade IB was always associated with placental pathology. The sensitivity and negative predictive value of placental pathology for moderate echogenicity changes were high (0.91 and 0.88, respectively), while the specificity and positive predictive value were low (0.27 and 0.34, respectively). Conclusions Normal placental histology predicted no or mild echogenicity changes, supporting the view that the latter are physiological. Placental pathology was always present in cases with grade IB PVE, presumed to represent mild or early forms of white matter injury. Both uteroplacental hypoperfusion and inflammatory features were seen in placentas from pregnancies with hypertensive disorders.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>20736417</pmid><doi>10.1136/adc.2009.181198</doi></addata></record> |
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| subjects | Brain - embryology Brain Injuries - diagnostic imaging Brain Injuries - pathology Echoencephalography - methods Epidemiologic Methods Female Gestational Age Histology Humans Hypertension - pathology Hypertension - physiopathology Hypoxia Obstetric Labor, Premature - pathology Pathology Placenta - pathology Placental Circulation Pregnancy Pregnancy Complications, Cardiovascular - pathology Pregnancy Complications, Cardiovascular - physiopathology Ultrasonography, Prenatal - methods Umbilical Cord - pathology |
| title | Placental histology related to fetal brain sonography |
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