Mammalian ER stress sensor IRE1β specifically down-regulates the synthesis of secretory pathway proteins

Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes ER stress. The ER stress sensor inositol requiring enzyme-1beta (IRE1β), which is specifically expressed in intestinal epithelial cells, is thought to be involved in translational repression. However, its mechanism of action...

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Veröffentlicht in:	FEBS letters 2011-01, Vol.585 (1), p.133-138
Hauptverfasser:	Nakamura, Daisuke, Tsuru, Akio, Ikegami, Kentaro, Imagawa, Yusuke, Fujimoto, Naoko, Kohno, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTB actin beta B2M beta-2-microglobulin Blotting, Western CD59 CD59 molecule, complement regulatory protein Cytosol - metabolism Down-Regulation endoplasmic reticulum Endoplasmic Reticulum - metabolism Endoplasmic reticulum stress Endoribonucleases - genetics Endoribonucleases - metabolism FBLN1 FBN1 fibrillin 1 fibulin 1 GAPDH glyceraldehyde-3-phosphate dehydrogenase Glycoproteins - genetics Glycoproteins - metabolism glycosyltransferase-like 1B GYLTL1B HeLa Cells hIRE1 hPERK human inositol-requiring enzyme 1 human PKR-like endoplasmic reticulum kinase Humans IRE1β LAMP1 lysosomal-associated membrane protein 1 Membrane Proteins - genetics Membrane Proteins - metabolism NFKB1 nuclear factor kappa-B p105 subunit Protein Biosynthesis Protein Transport Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Reverse Transcriptase Polymerase Chain Reaction Ribonucleases - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism SCARA3 scavenger receptor class A member 3 Secretory Pathway Secretory proteins Stress, Physiological TATA box binding protein TBP1 TFRC transferrin receptor Unfolded protein response UPR
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