Clinical and genetic risk factors for moderate hyperbilirubinemia in Brazilian newborn infants
Objective: To identify clinical and genetic risk factors for moderate hyperbilirubinemia during the first week of life. Study Design: Using univariate and multivariate multiple regression analyses, the RR for clinical factors, the African variant of glucose-6-phosphate dehydrogenase (G6PD) deficienc...
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| Veröffentlicht in: | Journal of perinatology 2010-12, Vol.30 (12), p.819-826 |
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| creator | Mezzacappa, M A Facchini, F P Pinto, A C Cassone, A E L Souza, D S Bezerra, M A C Albuquerque, D M Saad, S T O Costa, F F |
| description | Objective:
To identify clinical and genetic risk factors for moderate hyperbilirubinemia during the first week of life.
Study Design:
Using univariate and multivariate multiple regression analyses, the RR for clinical factors, the African variant of glucose-6-phosphate dehydrogenase (G6PD) deficiency (G202A/A376G), and (TA)
n
UGT1A1 polymorphisms were established in a cohort of 608 Brazilian newborn infants. Hyperbilirubinemia was monitored until 134.5±49.8 h of life (IQR, 111.0 to 156.7). The dependent variable was total bilirubinemia (TB)⩾12.9 mg per 100 ml estimated by transcutaneous or plasma bilirubin measurements.
Result:
The African variant of G6PD deficiency and (TA)
7
/(TA)
7
and (TA)
7
/(TA)
8
polymorphisms present in 6.1 and 12.0% of newborns, respectively, were not risk factors for moderate hyperbilirubinemia. Coexpression of G6DP deficiency and UGT1A1 polymorphisms occurred in 0.49% of the subjects. Independent clinical predictors for TB⩾12.9 mg per 100 ml were gestational age P40th.
Conclusion:
In this study, G6PD deficiency and UGT1A1 gene promoter polymorphisms were not risk factors for moderate hyperbilirubinemia. Genetic factors may vary considerably in importance among different populations. |
| doi_str_mv | 10.1038/jp.2010.48 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_954608524</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A243634980</galeid><sourcerecordid>A243634980</sourcerecordid><originalsourceid>FETCH-LOGICAL-c530t-e2e56c3598095fdc51e671c61759e059f2398d4a3d5420c18a55ec63bac125273</originalsourceid><addsrcrecordid>eNqFkl2L1DAUhoMo7jh64w-QoKCgzJjPNr1cB79gwRu9taTp6Uxqm3STFFl_vamz7rriB7kIOec5b3hfDkIPKdlSwtXLftoykh9C3UIrKspiI6Xgt9GKlIJvFBfFCboXY0_I0izvohNGeFkQqVbo826wzho9YO1avAcHyRocbPyCO22SDxF3PuDRtxB0Any4mCA0drBhbqyD0WpsHX4V9Ldc0w47-Nr44HKx0y7F--hOp4cIDy7vNfr05vXH3bvN2Ye373enZxsjOUkbYCALw2WlSCW71kgKRUlNQUtZAZFVx3ilWqF5KwUjhiotJZiCN9pQJlnJ1-jZUXcK_nyGmOrRRgPDoB34OdaVFAVRkon_korm8BQnNJOPfyN7PweXbSwQ5az6IffkbxArRI5YUFVeU3s9QJ2z8Slos3xcn2aRgovsPFPbP1D5tDln4x10NtdvDDz9ZeAAekiH6Ic5We_iTfD5ETTBxxigq6dgRx0uakrqZYfqfqqXHaqz9TV6dGlpbkZor9CfS5OBF0cg5pbbQ7j2_C85p9Mc4EqunxYiA98B6_HV0A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2640584187</pqid></control><display><type>article</type><title>Clinical and genetic risk factors for moderate hyperbilirubinemia in Brazilian newborn infants</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Mezzacappa, M A ; Facchini, F P ; Pinto, A C ; Cassone, A E L ; Souza, D S ; Bezerra, M A C ; Albuquerque, D M ; Saad, S T O ; Costa, F F</creator><creatorcontrib>Mezzacappa, M A ; Facchini, F P ; Pinto, A C ; Cassone, A E L ; Souza, D S ; Bezerra, M A C ; Albuquerque, D M ; Saad, S T O ; Costa, F F</creatorcontrib><description>Objective:
To identify clinical and genetic risk factors for moderate hyperbilirubinemia during the first week of life.
Study Design:
Using univariate and multivariate multiple regression analyses, the RR for clinical factors, the African variant of glucose-6-phosphate dehydrogenase (G6PD) deficiency (G202A/A376G), and (TA)
n
UGT1A1 polymorphisms were established in a cohort of 608 Brazilian newborn infants. Hyperbilirubinemia was monitored until 134.5±49.8 h of life (IQR, 111.0 to 156.7). The dependent variable was total bilirubinemia (TB)⩾12.9 mg per 100 ml estimated by transcutaneous or plasma bilirubin measurements.
Result:
The African variant of G6PD deficiency and (TA)
7
/(TA)
7
and (TA)
7
/(TA)
8
polymorphisms present in 6.1 and 12.0% of newborns, respectively, were not risk factors for moderate hyperbilirubinemia. Coexpression of G6DP deficiency and UGT1A1 polymorphisms occurred in 0.49% of the subjects. Independent clinical predictors for TB⩾12.9 mg per 100 ml were gestational age <38 weeks and reference curve percentiles >P40th.
Conclusion:
In this study, G6PD deficiency and UGT1A1 gene promoter polymorphisms were not risk factors for moderate hyperbilirubinemia. Genetic factors may vary considerably in importance among different populations.</description><identifier>ISSN: 0743-8346</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/jp.2010.48</identifier><identifier>PMID: 20376058</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/499 ; 692/700/1720 ; Bilirubin ; Brazil ; Cohort Studies ; Cross-Cultural Comparison ; Dependent variables ; Diagnosis ; Female ; Follow-Up Studies ; Genetic aspects ; Genetic Carrier Screening ; Genetic factors ; Genetic polymorphisms ; Genotype ; Gestational age ; Glucose 6 phosphate dehydrogenase ; Glucosephosphate dehydrogenase ; Glucosephosphate Dehydrogenase Deficiency - diagnosis ; Glucosephosphate Dehydrogenase Deficiency - genetics ; Glucuronosyltransferase - genetics ; Health aspects ; Humans ; Hyperbilirubinemia ; Hyperbilirubinemia, Neonatal - diagnosis ; Hyperbilirubinemia, Neonatal - genetics ; Infant, Newborn ; Infants ; Infants (Newborn) ; Jaundice ; Kernicterus - diagnosis ; Kernicterus - genetics ; Male ; Medicine ; Medicine & Public Health ; Multiple regression analysis ; Neonatal Screening ; Neonates ; Newborn babies ; original-article ; Pediatric Surgery ; Pediatrics ; Polymorphism, Genetic - genetics ; Prospective Studies ; Risk analysis ; Risk Factors</subject><ispartof>Journal of perinatology, 2010-12, Vol.30 (12), p.819-826</ispartof><rights>Nature America, Inc. 2010</rights><rights>COPYRIGHT 2010 Nature Publishing Group</rights><rights>Nature America, Inc. 2010.</rights><rights>Copyright Nature Publishing Group Dec 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-e2e56c3598095fdc51e671c61759e059f2398d4a3d5420c18a55ec63bac125273</citedby><cites>FETCH-LOGICAL-c530t-e2e56c3598095fdc51e671c61759e059f2398d4a3d5420c18a55ec63bac125273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20376058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mezzacappa, M A</creatorcontrib><creatorcontrib>Facchini, F P</creatorcontrib><creatorcontrib>Pinto, A C</creatorcontrib><creatorcontrib>Cassone, A E L</creatorcontrib><creatorcontrib>Souza, D S</creatorcontrib><creatorcontrib>Bezerra, M A C</creatorcontrib><creatorcontrib>Albuquerque, D M</creatorcontrib><creatorcontrib>Saad, S T O</creatorcontrib><creatorcontrib>Costa, F F</creatorcontrib><title>Clinical and genetic risk factors for moderate hyperbilirubinemia in Brazilian newborn infants</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective:
To identify clinical and genetic risk factors for moderate hyperbilirubinemia during the first week of life.
Study Design:
Using univariate and multivariate multiple regression analyses, the RR for clinical factors, the African variant of glucose-6-phosphate dehydrogenase (G6PD) deficiency (G202A/A376G), and (TA)
n
UGT1A1 polymorphisms were established in a cohort of 608 Brazilian newborn infants. Hyperbilirubinemia was monitored until 134.5±49.8 h of life (IQR, 111.0 to 156.7). The dependent variable was total bilirubinemia (TB)⩾12.9 mg per 100 ml estimated by transcutaneous or plasma bilirubin measurements.
Result:
The African variant of G6PD deficiency and (TA)
7
/(TA)
7
and (TA)
7
/(TA)
8
polymorphisms present in 6.1 and 12.0% of newborns, respectively, were not risk factors for moderate hyperbilirubinemia. Coexpression of G6DP deficiency and UGT1A1 polymorphisms occurred in 0.49% of the subjects. Independent clinical predictors for TB⩾12.9 mg per 100 ml were gestational age <38 weeks and reference curve percentiles >P40th.
Conclusion:
In this study, G6PD deficiency and UGT1A1 gene promoter polymorphisms were not risk factors for moderate hyperbilirubinemia. Genetic factors may vary considerably in importance among different populations.</description><subject>692/499</subject><subject>692/700/1720</subject><subject>Bilirubin</subject><subject>Brazil</subject><subject>Cohort Studies</subject><subject>Cross-Cultural Comparison</subject><subject>Dependent variables</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Genetic aspects</subject><subject>Genetic Carrier Screening</subject><subject>Genetic factors</subject><subject>Genetic polymorphisms</subject><subject>Genotype</subject><subject>Gestational age</subject><subject>Glucose 6 phosphate dehydrogenase</subject><subject>Glucosephosphate dehydrogenase</subject><subject>Glucosephosphate Dehydrogenase Deficiency - diagnosis</subject><subject>Glucosephosphate Dehydrogenase Deficiency - genetics</subject><subject>Glucuronosyltransferase - genetics</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hyperbilirubinemia</subject><subject>Hyperbilirubinemia, Neonatal - diagnosis</subject><subject>Hyperbilirubinemia, Neonatal - genetics</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Infants (Newborn)</subject><subject>Jaundice</subject><subject>Kernicterus - diagnosis</subject><subject>Kernicterus - genetics</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multiple regression analysis</subject><subject>Neonatal Screening</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>original-article</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Prospective Studies</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><issn>0743-8346</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkl2L1DAUhoMo7jh64w-QoKCgzJjPNr1cB79gwRu9taTp6Uxqm3STFFl_vamz7rriB7kIOec5b3hfDkIPKdlSwtXLftoykh9C3UIrKspiI6Xgt9GKlIJvFBfFCboXY0_I0izvohNGeFkQqVbo826wzho9YO1avAcHyRocbPyCO22SDxF3PuDRtxB0Any4mCA0drBhbqyD0WpsHX4V9Ldc0w47-Nr44HKx0y7F--hOp4cIDy7vNfr05vXH3bvN2Ye373enZxsjOUkbYCALw2WlSCW71kgKRUlNQUtZAZFVx3ilWqF5KwUjhiotJZiCN9pQJlnJ1-jZUXcK_nyGmOrRRgPDoB34OdaVFAVRkon_korm8BQnNJOPfyN7PweXbSwQ5az6IffkbxArRI5YUFVeU3s9QJ2z8Slos3xcn2aRgovsPFPbP1D5tDln4x10NtdvDDz9ZeAAekiH6Ic5We_iTfD5ETTBxxigq6dgRx0uakrqZYfqfqqXHaqz9TV6dGlpbkZor9CfS5OBF0cg5pbbQ7j2_C85p9Mc4EqunxYiA98B6_HV0A</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Mezzacappa, M A</creator><creator>Facchini, F P</creator><creator>Pinto, A C</creator><creator>Cassone, A E L</creator><creator>Souza, D S</creator><creator>Bezerra, M A C</creator><creator>Albuquerque, D M</creator><creator>Saad, S T O</creator><creator>Costa, F F</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>RC3</scope></search><sort><creationdate>20101201</creationdate><title>Clinical and genetic risk factors for moderate hyperbilirubinemia in Brazilian newborn infants</title><author>Mezzacappa, M A ; Facchini, F P ; Pinto, A C ; Cassone, A E L ; Souza, D S ; Bezerra, M A C ; Albuquerque, D M ; Saad, S T O ; Costa, F F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-e2e56c3598095fdc51e671c61759e059f2398d4a3d5420c18a55ec63bac125273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>692/499</topic><topic>692/700/1720</topic><topic>Bilirubin</topic><topic>Brazil</topic><topic>Cohort Studies</topic><topic>Cross-Cultural Comparison</topic><topic>Dependent variables</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Genetic aspects</topic><topic>Genetic Carrier Screening</topic><topic>Genetic factors</topic><topic>Genetic polymorphisms</topic><topic>Genotype</topic><topic>Gestational age</topic><topic>Glucose 6 phosphate dehydrogenase</topic><topic>Glucosephosphate dehydrogenase</topic><topic>Glucosephosphate Dehydrogenase Deficiency - diagnosis</topic><topic>Glucosephosphate Dehydrogenase Deficiency - genetics</topic><topic>Glucuronosyltransferase - genetics</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hyperbilirubinemia</topic><topic>Hyperbilirubinemia, Neonatal - diagnosis</topic><topic>Hyperbilirubinemia, Neonatal - genetics</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Infants (Newborn)</topic><topic>Jaundice</topic><topic>Kernicterus - diagnosis</topic><topic>Kernicterus - genetics</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multiple regression analysis</topic><topic>Neonatal Screening</topic><topic>Neonates</topic><topic>Newborn babies</topic><topic>original-article</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Prospective Studies</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mezzacappa, M A</creatorcontrib><creatorcontrib>Facchini, F P</creatorcontrib><creatorcontrib>Pinto, A C</creatorcontrib><creatorcontrib>Cassone, A E L</creatorcontrib><creatorcontrib>Souza, D S</creatorcontrib><creatorcontrib>Bezerra, M A C</creatorcontrib><creatorcontrib>Albuquerque, D M</creatorcontrib><creatorcontrib>Saad, S T O</creatorcontrib><creatorcontrib>Costa, F F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Genetics Abstracts</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mezzacappa, M A</au><au>Facchini, F P</au><au>Pinto, A C</au><au>Cassone, A E L</au><au>Souza, D S</au><au>Bezerra, M A C</au><au>Albuquerque, D M</au><au>Saad, S T O</au><au>Costa, F F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and genetic risk factors for moderate hyperbilirubinemia in Brazilian newborn infants</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>30</volume><issue>12</issue><spage>819</spage><epage>826</epage><pages>819-826</pages><issn>0743-8346</issn><eissn>1476-5543</eissn><abstract>Objective:
To identify clinical and genetic risk factors for moderate hyperbilirubinemia during the first week of life.
Study Design:
Using univariate and multivariate multiple regression analyses, the RR for clinical factors, the African variant of glucose-6-phosphate dehydrogenase (G6PD) deficiency (G202A/A376G), and (TA)
n
UGT1A1 polymorphisms were established in a cohort of 608 Brazilian newborn infants. Hyperbilirubinemia was monitored until 134.5±49.8 h of life (IQR, 111.0 to 156.7). The dependent variable was total bilirubinemia (TB)⩾12.9 mg per 100 ml estimated by transcutaneous or plasma bilirubin measurements.
Result:
The African variant of G6PD deficiency and (TA)
7
/(TA)
7
and (TA)
7
/(TA)
8
polymorphisms present in 6.1 and 12.0% of newborns, respectively, were not risk factors for moderate hyperbilirubinemia. Coexpression of G6DP deficiency and UGT1A1 polymorphisms occurred in 0.49% of the subjects. Independent clinical predictors for TB⩾12.9 mg per 100 ml were gestational age <38 weeks and reference curve percentiles >P40th.
Conclusion:
In this study, G6PD deficiency and UGT1A1 gene promoter polymorphisms were not risk factors for moderate hyperbilirubinemia. Genetic factors may vary considerably in importance among different populations.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>20376058</pmid><doi>10.1038/jp.2010.48</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 692/499 692/700/1720 Bilirubin Brazil Cohort Studies Cross-Cultural Comparison Dependent variables Diagnosis Female Follow-Up Studies Genetic aspects Genetic Carrier Screening Genetic factors Genetic polymorphisms Genotype Gestational age Glucose 6 phosphate dehydrogenase Glucosephosphate dehydrogenase Glucosephosphate Dehydrogenase Deficiency - diagnosis Glucosephosphate Dehydrogenase Deficiency - genetics Glucuronosyltransferase - genetics Health aspects Humans Hyperbilirubinemia Hyperbilirubinemia, Neonatal - diagnosis Hyperbilirubinemia, Neonatal - genetics Infant, Newborn Infants Infants (Newborn) Jaundice Kernicterus - diagnosis Kernicterus - genetics Male Medicine Medicine & Public Health Multiple regression analysis Neonatal Screening Neonates Newborn babies original-article Pediatric Surgery Pediatrics Polymorphism, Genetic - genetics Prospective Studies Risk analysis Risk Factors |
| title | Clinical and genetic risk factors for moderate hyperbilirubinemia in Brazilian newborn infants |
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