Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways

We have previously shown that the plant-derived compound parthenolide (PTL) can impair the survival and leukemogenic activity of primary human acute myeloid leukemia (AML) stem cells. However, despite the activity of this agent, PTL also induces cellular protective responses that likely function to...

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Veröffentlicht in:	Blood 2010-12, Vol.116 (26), p.5983-5990
Hauptverfasser:	Hassane, Duane C., Sen, Siddhartha, Minhajuddin, Mohammad, Rossi, Randall M., Corbett, Cheryl A., Balys, Marlene, Wei, Liping, Crooks, Peter A., Guzman, Monica L., Jordan, Craig T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Blotting, Western Bone Marrow - drug effects Cell Proliferation - drug effects Cells, Cultured Drug Synergism Enzyme Inhibitors - pharmacology Flow Cytometry Gene Expression Profiling Hematologic and hematopoietic diseases Humans Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Medical sciences Mice Mice, Inbred NOD Mice, SCID Oligonucleotide Array Sequence Analysis Phosphatidylinositol 3-Kinases - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Sesquiterpenes - pharmacology Sirolimus - analogs & derivatives Sirolimus - pharmacology TOR Serine-Threonine Kinases - metabolism
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