Short-term effect of combined drug therapy and cognitive stimulation therapy on the cognitive function of Alzheimer's disease
Background: Acetylcholinesterase inhibitors (i.e. donepezil) are known to benefit Alzheimer's disease (AD) patients. However, the combined effects of acetylcholinesterase and cognitive stimulation therapy (CST) are still debated. The present study examined their combined effects on the progres...
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| Veröffentlicht in: | Psychogeriatrics 2010-12, Vol.10 (4), p.167-172 |
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| container_title | Psychogeriatrics |
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| creator | MATSUDA, Osamu SHIDO, Emi HASHIKAI, Ayako SHIBUYA, Haruka KOUNO, Mitsue HARA, Chizuko SAITO, Masahiko |
| description | Background: Acetylcholinesterase inhibitors (i.e. donepezil) are known to benefit Alzheimer's disease (AD) patients. However, the combined effects of acetylcholinesterase and cognitive stimulation therapy (CST) are still debated. The present study examined their combined effects on the progression of cognitive decline in AD.
Methods: The present study was a non‐randomized controlled study and included two groups of patients with AD (i.e. CST group and control group). The CST group consisted of 31 patients with AD who received donepezil and weekly, 30‐min CST sessions over the course of 7 weeks. The control group consisted of 18 patients who received only donepezil. Changes in cognitive abilities were assessed with Hasegawa's Dementia Scale‐Revised (HDS‐R) and were statistically analyzed by repeated‐measure analysis of variance (anova).
Results: ANOVA showed a significant group × time interaction effect on the HDS‐R score. HDS‐R scores for the CST group increased significantly during the intervention period, whereas the scores for the control group did not increase. Differences between the means of pre‐ and post‐test HDS‐R scores were significantly different between the groups; scores were significantly higher for the CST group than the control group. The groups differed significantly in the proportion of subjects whose score increased by more than four points on the HDS‐R (Fisher's exact test, P < 0.05; 8 patients (25.8%) in the CST group and none (0.0%) in the control group).
Conclusions: These results suggest that CST is one of the important non‐pharmacological treatment strategies for patients with AD. |
| doi_str_mv | 10.1111/j.1479-8301.2010.00335.x |
| format | Article |
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Methods: The present study was a non‐randomized controlled study and included two groups of patients with AD (i.e. CST group and control group). The CST group consisted of 31 patients with AD who received donepezil and weekly, 30‐min CST sessions over the course of 7 weeks. The control group consisted of 18 patients who received only donepezil. Changes in cognitive abilities were assessed with Hasegawa's Dementia Scale‐Revised (HDS‐R) and were statistically analyzed by repeated‐measure analysis of variance (anova).
Results: ANOVA showed a significant group × time interaction effect on the HDS‐R score. HDS‐R scores for the CST group increased significantly during the intervention period, whereas the scores for the control group did not increase. Differences between the means of pre‐ and post‐test HDS‐R scores were significantly different between the groups; scores were significantly higher for the CST group than the control group. The groups differed significantly in the proportion of subjects whose score increased by more than four points on the HDS‐R (Fisher's exact test, P < 0.05; 8 patients (25.8%) in the CST group and none (0.0%) in the control group).
Conclusions: These results suggest that CST is one of the important non‐pharmacological treatment strategies for patients with AD.</description><identifier>ISSN: 1346-3500</identifier><identifier>EISSN: 1479-8301</identifier><identifier>DOI: 10.1111/j.1479-8301.2010.00335.x</identifier><identifier>PMID: 21159050</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - therapy ; Alzheimer's disease ; Cholinesterase Inhibitors - therapeutic use ; Cognition & reasoning ; cognitive rehabilitation ; cognitive stimulation therapy ; Combined Modality Therapy ; Drug therapy ; Female ; Follow-Up Studies ; Humans ; Indans - therapeutic use ; Indexing in process ; Male ; Mathematics ; Neuropsychological Tests ; non-pharmacological treatment ; Piperidines - therapeutic use ; Problem Solving ; Reading ; Verbal Learning</subject><ispartof>Psychogeriatrics, 2010-12, Vol.10 (4), p.167-172</ispartof><rights>2010 The Authors. Psychogeriatrics © 2010 Japanese Psychogeriatric Society</rights><rights>2010 The Authors. Psychogeriatrics © 2010 Japanese Psychogeriatric Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5855-de45b3a6c2af089ea70b2341fe56aa057e207334412ddba903b552a2ca5a28593</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1479-8301.2010.00335.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1479-8301.2010.00335.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21159050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MATSUDA, Osamu</creatorcontrib><creatorcontrib>SHIDO, Emi</creatorcontrib><creatorcontrib>HASHIKAI, Ayako</creatorcontrib><creatorcontrib>SHIBUYA, Haruka</creatorcontrib><creatorcontrib>KOUNO, Mitsue</creatorcontrib><creatorcontrib>HARA, Chizuko</creatorcontrib><creatorcontrib>SAITO, Masahiko</creatorcontrib><title>Short-term effect of combined drug therapy and cognitive stimulation therapy on the cognitive function of Alzheimer's disease</title><title>Psychogeriatrics</title><addtitle>Psychogeriatrics</addtitle><description>Background: Acetylcholinesterase inhibitors (i.e. donepezil) are known to benefit Alzheimer's disease (AD) patients. However, the combined effects of acetylcholinesterase and cognitive stimulation therapy (CST) are still debated. The present study examined their combined effects on the progression of cognitive decline in AD.
Methods: The present study was a non‐randomized controlled study and included two groups of patients with AD (i.e. CST group and control group). The CST group consisted of 31 patients with AD who received donepezil and weekly, 30‐min CST sessions over the course of 7 weeks. The control group consisted of 18 patients who received only donepezil. Changes in cognitive abilities were assessed with Hasegawa's Dementia Scale‐Revised (HDS‐R) and were statistically analyzed by repeated‐measure analysis of variance (anova).
Results: ANOVA showed a significant group × time interaction effect on the HDS‐R score. HDS‐R scores for the CST group increased significantly during the intervention period, whereas the scores for the control group did not increase. Differences between the means of pre‐ and post‐test HDS‐R scores were significantly different between the groups; scores were significantly higher for the CST group than the control group. The groups differed significantly in the proportion of subjects whose score increased by more than four points on the HDS‐R (Fisher's exact test, P < 0.05; 8 patients (25.8%) in the CST group and none (0.0%) in the control group).
Conclusions: These results suggest that CST is one of the important non‐pharmacological treatment strategies for patients with AD.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - therapy</subject><subject>Alzheimer's disease</subject><subject>Cholinesterase Inhibitors - therapeutic use</subject><subject>Cognition & reasoning</subject><subject>cognitive rehabilitation</subject><subject>cognitive stimulation therapy</subject><subject>Combined Modality Therapy</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Indans - therapeutic use</subject><subject>Indexing in process</subject><subject>Male</subject><subject>Mathematics</subject><subject>Neuropsychological Tests</subject><subject>non-pharmacological treatment</subject><subject>Piperidines - therapeutic use</subject><subject>Problem Solving</subject><subject>Reading</subject><subject>Verbal Learning</subject><issn>1346-3500</issn><issn>1479-8301</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEUhS0Eoi_-ArLYdDWpn2PPgkVVQVopCkihINhYnpk7jcM8UtsDCRL_vU5TIsQGb3zk8517ZR2EMCUTms7FakKFKjLNCZ0wkl4J4VxONs_Q8cF4njQXecYlIUfoJIQVIUxIzl-iI0apLIgkx-j3Yjn4mEXwHYamgSriocHV0JWuhxrXfrzDcQnerrfY9nVy7noX3Q_AIbpubG10Q38g9vIvqBn76pFIQy_bX0twHfjzgGsXwAY4Qy8a2wZ49XSfotv37z5dXWezD9Obq8tZVkktZVaDkCW3ecVsQ3QBVpGScUEbkLm1RCpgRHEuBGV1XdqC8FJKZlllpWVaFvwUne_nrv1wP0KIpnOhgra1PQxjMIUUOcm10v8lNdW5SNtYIt_8Q66G0ffpGwlSOVdC0QS9foLGsoParL3rrN-aPwUk4O0e-Ola2B58SsyuaLMyuz7Nrk-zK9o8Fm025uPi6zSplM_2eRcibA5567-bXHElzZf51Oj5t88zNV-Ya_4ARfurrQ</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>MATSUDA, Osamu</creator><creator>SHIDO, Emi</creator><creator>HASHIKAI, Ayako</creator><creator>SHIBUYA, Haruka</creator><creator>KOUNO, Mitsue</creator><creator>HARA, Chizuko</creator><creator>SAITO, Masahiko</creator><general>Blackwell Publishing Asia</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>201012</creationdate><title>Short-term effect of combined drug therapy and cognitive stimulation therapy on the cognitive function of Alzheimer's disease</title><author>MATSUDA, Osamu ; SHIDO, Emi ; HASHIKAI, Ayako ; SHIBUYA, Haruka ; KOUNO, Mitsue ; HARA, Chizuko ; SAITO, Masahiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5855-de45b3a6c2af089ea70b2341fe56aa057e207334412ddba903b552a2ca5a28593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - therapy</topic><topic>Alzheimer's disease</topic><topic>Cholinesterase Inhibitors - therapeutic use</topic><topic>Cognition & reasoning</topic><topic>cognitive rehabilitation</topic><topic>cognitive stimulation therapy</topic><topic>Combined Modality Therapy</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Indans - therapeutic use</topic><topic>Indexing in process</topic><topic>Male</topic><topic>Mathematics</topic><topic>Neuropsychological Tests</topic><topic>non-pharmacological treatment</topic><topic>Piperidines - therapeutic use</topic><topic>Problem Solving</topic><topic>Reading</topic><topic>Verbal Learning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MATSUDA, Osamu</creatorcontrib><creatorcontrib>SHIDO, Emi</creatorcontrib><creatorcontrib>HASHIKAI, Ayako</creatorcontrib><creatorcontrib>SHIBUYA, Haruka</creatorcontrib><creatorcontrib>KOUNO, Mitsue</creatorcontrib><creatorcontrib>HARA, Chizuko</creatorcontrib><creatorcontrib>SAITO, Masahiko</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Psychogeriatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MATSUDA, Osamu</au><au>SHIDO, Emi</au><au>HASHIKAI, Ayako</au><au>SHIBUYA, Haruka</au><au>KOUNO, Mitsue</au><au>HARA, Chizuko</au><au>SAITO, Masahiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short-term effect of combined drug therapy and cognitive stimulation therapy on the cognitive function of Alzheimer's disease</atitle><jtitle>Psychogeriatrics</jtitle><addtitle>Psychogeriatrics</addtitle><date>2010-12</date><risdate>2010</risdate><volume>10</volume><issue>4</issue><spage>167</spage><epage>172</epage><pages>167-172</pages><issn>1346-3500</issn><eissn>1479-8301</eissn><abstract>Background: Acetylcholinesterase inhibitors (i.e. donepezil) are known to benefit Alzheimer's disease (AD) patients. However, the combined effects of acetylcholinesterase and cognitive stimulation therapy (CST) are still debated. The present study examined their combined effects on the progression of cognitive decline in AD.
Methods: The present study was a non‐randomized controlled study and included two groups of patients with AD (i.e. CST group and control group). The CST group consisted of 31 patients with AD who received donepezil and weekly, 30‐min CST sessions over the course of 7 weeks. The control group consisted of 18 patients who received only donepezil. Changes in cognitive abilities were assessed with Hasegawa's Dementia Scale‐Revised (HDS‐R) and were statistically analyzed by repeated‐measure analysis of variance (anova).
Results: ANOVA showed a significant group × time interaction effect on the HDS‐R score. HDS‐R scores for the CST group increased significantly during the intervention period, whereas the scores for the control group did not increase. Differences between the means of pre‐ and post‐test HDS‐R scores were significantly different between the groups; scores were significantly higher for the CST group than the control group. The groups differed significantly in the proportion of subjects whose score increased by more than four points on the HDS‐R (Fisher's exact test, P < 0.05; 8 patients (25.8%) in the CST group and none (0.0%) in the control group).
Conclusions: These results suggest that CST is one of the important non‐pharmacological treatment strategies for patients with AD.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>21159050</pmid><doi>10.1111/j.1479-8301.2010.00335.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Psychogeriatrics, 2010-12, Vol.10 (4), p.167-172 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Aged Aged, 80 and over Alzheimer Disease - therapy Alzheimer's disease Cholinesterase Inhibitors - therapeutic use Cognition & reasoning cognitive rehabilitation cognitive stimulation therapy Combined Modality Therapy Drug therapy Female Follow-Up Studies Humans Indans - therapeutic use Indexing in process Male Mathematics Neuropsychological Tests non-pharmacological treatment Piperidines - therapeutic use Problem Solving Reading Verbal Learning |
| title | Short-term effect of combined drug therapy and cognitive stimulation therapy on the cognitive function of Alzheimer's disease |
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