Relationship between TNFA, TNFB and TNFRII gene polymorphisms and outcome after unrelated hematopoietic cell transplantation in a Chinese population
This study aimed to analyze the association between cytokine gene polymorphisms and outcome following allogeneic hematopoietic SCT (allo-HSCT). A total of 138 unrelated donor/recipient pairs who underwent allo-HSCT from 2001 to 2009 were tested for TNFA-1031 (T>C), -863 (C>A), -857 (C>T), -...
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| creator | Xiao, H W Lai, X Y Luo, Y Shi, J M Tan, Y M He, J S Xie, W Z Li, L Zhu, X L Zhu, J J Sun, J Wei, G Q Jin, L Liu, L Z Wu, K N Yu, X H Cai, Z Lin, M F Ye, X J Huang, H |
| description | This study aimed to analyze the association between cytokine gene polymorphisms and outcome following allogeneic hematopoietic SCT (allo-HSCT). A total of 138 unrelated donor/recipient pairs who underwent allo-HSCT from 2001 to 2009 were tested for TNFA-1031 (T>C), -863 (C>A), -857 (C>T), -238 (G>A), TNFB+252 (A>G) and TNFRII codon 196 (T>G) single nucleotide polymorphisms by multiplex SnaPshot analysis. Transplantation involving recipients and/or donors with TNFA-857 C/C genotype or TNFB+252 G allele-positivity resulted in a higher incidence of acute GVHD (aGVHD), which was independent of HLA mismatching. In multivariate analysis, TNFA-857 C/C genotype donors (relative risk (RR)=2.29,
P
=0.006) and TNFB+252 G allele-positive recipients (RR=1.789,
P
=0.036) were found to be significantly associated with an increased incidence of aGVHD. TNFA-857 C/C genotype donors (RR=3.748,
P
=0.002) and TNFB+252 G allele-positive recipients (RR=1.823,
P
=0.063) were also associated with the development of grades II–IV aGVHD. TNFRII polymorphism in recipients was also related to relapse rate, but no significant associations were found between TNFA, TNFB or TNFRII 196 genotype and cGVHD, relapse or overall survival after transplantation. These results provide the first report of an association between TNFA, TNFB and TNFRII polymorphic features and outcome of allo-HSCT in a Chinese population, and suggest an interaction between TNFA-857 and TNFB+252 genotypes and risk of aGVHD. |
| doi_str_mv | 10.1038/bmt.2010.135 |
| format | Article |
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P
=0.006) and TNFB+252 G allele-positive recipients (RR=1.789,
P
=0.036) were found to be significantly associated with an increased incidence of aGVHD. TNFA-857 C/C genotype donors (RR=3.748,
P
=0.002) and TNFB+252 G allele-positive recipients (RR=1.823,
P
=0.063) were also associated with the development of grades II–IV aGVHD. TNFRII polymorphism in recipients was also related to relapse rate, but no significant associations were found between TNFA, TNFB or TNFRII 196 genotype and cGVHD, relapse or overall survival after transplantation. These results provide the first report of an association between TNFA, TNFB and TNFRII polymorphic features and outcome of allo-HSCT in a Chinese population, and suggest an interaction between TNFA-857 and TNFB+252 genotypes and risk of aGVHD.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/bmt.2010.135</identifier><identifier>PMID: 20548340</identifier><identifier>CODEN: BMTRE9</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208/726/649 ; 631/45/127/1220 ; 692/699/249/1529 ; 692/700/565/545/576/1955 ; Adolescent ; Adult ; Alleles ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Asian Continental Ancestry Group ; Biological and medical sciences ; Bone marrow ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Cell Biology ; Child ; China ; Codons ; Cohort Studies ; Cytokines ; Donors ; Female ; Gene polymorphism ; Genetic aspects ; Genetic polymorphisms ; Genotype & phenotype ; Genotypes ; Graft vs Host Disease - etiology ; Graft vs Host Disease - genetics ; Graft-versus-host reaction ; Health aspects ; Hematology ; Hematopoietic Stem Cell Transplantation ; Hematopoietic stem cells ; Hemopoiesis ; Histocompatibility antigen HLA ; Humans ; Internal Medicine ; Lymphotoxin-alpha - genetics ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate analysis ; Nucleotides ; original-article ; Physiological aspects ; Polymorphism ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Population studies ; Public Health ; Receptors, Tumor Necrosis Factor, Type II - genetics ; Risk assessment ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Stem cell transplantation ; Stem Cells ; Survival ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation ; Treatment Outcome ; Tumor necrosis factor ; Tumor necrosis factor- alpha ; Tumor Necrosis Factor-alpha - genetics ; Young Adult</subject><ispartof>Bone marrow transplantation (Basingstoke), 2011-03, Vol.46 (3), p.400-407</ispartof><rights>Macmillan Publishers Limited 2011</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Nature Publishing Group</rights><rights>Macmillan Publishers Limited 2011.</rights><rights>Copyright Nature Publishing Group Mar 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c666t-52d72d4a5b8957f231f0a5662262adedc8bca01cc1f5949737061efc975a30ee3</citedby><cites>FETCH-LOGICAL-c666t-52d72d4a5b8957f231f0a5662262adedc8bca01cc1f5949737061efc975a30ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/bmt.2010.135$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/bmt.2010.135$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2725,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23943089$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20548340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiao, H W</creatorcontrib><creatorcontrib>Lai, X Y</creatorcontrib><creatorcontrib>Luo, Y</creatorcontrib><creatorcontrib>Shi, J M</creatorcontrib><creatorcontrib>Tan, Y M</creatorcontrib><creatorcontrib>He, J S</creatorcontrib><creatorcontrib>Xie, W Z</creatorcontrib><creatorcontrib>Li, L</creatorcontrib><creatorcontrib>Zhu, X L</creatorcontrib><creatorcontrib>Zhu, J J</creatorcontrib><creatorcontrib>Sun, J</creatorcontrib><creatorcontrib>Wei, G Q</creatorcontrib><creatorcontrib>Jin, L</creatorcontrib><creatorcontrib>Liu, L Z</creatorcontrib><creatorcontrib>Wu, K N</creatorcontrib><creatorcontrib>Yu, X H</creatorcontrib><creatorcontrib>Cai, Z</creatorcontrib><creatorcontrib>Lin, M F</creatorcontrib><creatorcontrib>Ye, X J</creatorcontrib><creatorcontrib>Huang, H</creatorcontrib><title>Relationship between TNFA, TNFB and TNFRII gene polymorphisms and outcome after unrelated hematopoietic cell transplantation in a Chinese population</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><addtitle>Bone Marrow Transplant</addtitle><description>This study aimed to analyze the association between cytokine gene polymorphisms and outcome following allogeneic hematopoietic SCT (allo-HSCT). A total of 138 unrelated donor/recipient pairs who underwent allo-HSCT from 2001 to 2009 were tested for TNFA-1031 (T>C), -863 (C>A), -857 (C>T), -238 (G>A), TNFB+252 (A>G) and TNFRII codon 196 (T>G) single nucleotide polymorphisms by multiplex SnaPshot analysis. Transplantation involving recipients and/or donors with TNFA-857 C/C genotype or TNFB+252 G allele-positivity resulted in a higher incidence of acute GVHD (aGVHD), which was independent of HLA mismatching. In multivariate analysis, TNFA-857 C/C genotype donors (relative risk (RR)=2.29,
P
=0.006) and TNFB+252 G allele-positive recipients (RR=1.789,
P
=0.036) were found to be significantly associated with an increased incidence of aGVHD. TNFA-857 C/C genotype donors (RR=3.748,
P
=0.002) and TNFB+252 G allele-positive recipients (RR=1.823,
P
=0.063) were also associated with the development of grades II–IV aGVHD. TNFRII polymorphism in recipients was also related to relapse rate, but no significant associations were found between TNFA, TNFB or TNFRII 196 genotype and cGVHD, relapse or overall survival after transplantation. These results provide the first report of an association between TNFA, TNFB and TNFRII polymorphic features and outcome of allo-HSCT in a Chinese population, and suggest an interaction between TNFA-857 and TNFB+252 genotypes and risk of aGVHD.</description><subject>631/208/726/649</subject><subject>631/45/127/1220</subject><subject>692/699/249/1529</subject><subject>692/700/565/545/576/1955</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Alleles</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Asian Continental Ancestry Group</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Cell Biology</subject><subject>Child</subject><subject>China</subject><subject>Codons</subject><subject>Cohort Studies</subject><subject>Cytokines</subject><subject>Donors</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Graft vs Host Disease - etiology</subject><subject>Graft vs Host Disease - genetics</subject><subject>Graft-versus-host reaction</subject><subject>Health aspects</subject><subject>Hematology</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Hematopoietic stem cells</subject><subject>Hemopoiesis</subject><subject>Histocompatibility antigen HLA</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lymphotoxin-alpha - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Nucleotides</subject><subject>original-article</subject><subject>Physiological aspects</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population studies</subject><subject>Public Health</subject><subject>Receptors, Tumor Necrosis Factor, Type II - genetics</subject><subject>Risk assessment</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Stem cell transplantation</subject><subject>Stem Cells</subject><subject>Survival</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Transplantation</subject><subject>Treatment Outcome</subject><subject>Tumor necrosis factor</subject><subject>Tumor necrosis factor- alpha</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Young Adult</subject><issn>0268-3369</issn><issn>1476-5365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkl1v0zAUhiMEYmVwxzWyQMDNUvwRO_FlqRhUmkCaxnXkOieNp8TOYkdo_4MfjNOWliGmIUv-fPye4-M3SV4SPCeYFR_WXZhTPK0Yf5TMSJaLlDPBHyczTEWRMibkSfLM-2uMSZZh_jQ5oZhnBcvwLPl5Ca0KxlnfmB6tIfwAsOjq6_nibOo_ImWraXK5WqENWEC9a287N_SN8Z3fnroxaNcBUnWAAY12mBShQg10KrjeGQhGIw1ti8KgrO9bZcM2JjIWKbRsjAU_KffjLpfnyZNatR5e7MfT5Pv5p6vll_Ti2-fVcnGRaiFESDmtclpliq8LyfOaMlJjxYWgVFBVQaWLtVaYaE1qLjOZsxwLArWWOVcMA7DT5P1Otx_czQg-lJ3xU6LKght9KXkmYqWIeJAsuMiiOJaRfP0Xee3GwcZnRIhLIYssj9Cb-yAqMkoxI7k8UhvVQmls7WL99BS4XFBOiSQSFw9ROKZV4EjN_0HFVkFntLNQm7h_R_Z_LxwivPvjQgOqDY137bg1113lh8CD4tkO1IPzfoC67AfTqeG2JLicvF9G75eT98vo_Yi_2hd1XHdQHeDfZo_A2z2gvFZtHc2ojT9yTGYMF1Pd0x3n45HdwHD8nXsCox1vVRgHOAhGaGIm5Bd8uSCg</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Xiao, H W</creator><creator>Lai, X Y</creator><creator>Luo, Y</creator><creator>Shi, J M</creator><creator>Tan, Y M</creator><creator>He, J S</creator><creator>Xie, W Z</creator><creator>Li, L</creator><creator>Zhu, X L</creator><creator>Zhu, J J</creator><creator>Sun, J</creator><creator>Wei, G Q</creator><creator>Jin, L</creator><creator>Liu, L Z</creator><creator>Wu, K N</creator><creator>Yu, X H</creator><creator>Cai, Z</creator><creator>Lin, M F</creator><creator>Ye, X J</creator><creator>Huang, H</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>RC3</scope></search><sort><creationdate>20110301</creationdate><title>Relationship between TNFA, TNFB and TNFRII gene polymorphisms and outcome after unrelated hematopoietic cell transplantation in a Chinese population</title><author>Xiao, H W ; Lai, X Y ; Luo, Y ; Shi, J M ; Tan, Y M ; He, J S ; Xie, W Z ; Li, L ; Zhu, X L ; Zhu, J J ; Sun, J ; Wei, G Q ; Jin, L ; Liu, L Z ; Wu, K N ; Yu, X H ; Cai, Z ; Lin, M F ; Ye, X J ; Huang, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c666t-52d72d4a5b8957f231f0a5662262adedc8bca01cc1f5949737061efc975a30ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>631/208/726/649</topic><topic>631/45/127/1220</topic><topic>692/699/249/1529</topic><topic>692/700/565/545/576/1955</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Alleles</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Asian Continental Ancestry Group</topic><topic>Biological and medical sciences</topic><topic>Bone marrow</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Cell Biology</topic><topic>Child</topic><topic>China</topic><topic>Codons</topic><topic>Cohort Studies</topic><topic>Cytokines</topic><topic>Donors</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genotype & phenotype</topic><topic>Genotypes</topic><topic>Graft vs Host Disease - etiology</topic><topic>Graft vs Host Disease - genetics</topic><topic>Graft-versus-host reaction</topic><topic>Health aspects</topic><topic>Hematology</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Hematopoietic stem cells</topic><topic>Hemopoiesis</topic><topic>Histocompatibility antigen HLA</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lymphotoxin-alpha - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Nucleotides</topic><topic>original-article</topic><topic>Physiological aspects</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population studies</topic><topic>Public Health</topic><topic>Receptors, Tumor Necrosis Factor, Type II - genetics</topic><topic>Risk assessment</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Stem cell transplantation</topic><topic>Stem Cells</topic><topic>Survival</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Transplantation</topic><topic>Treatment Outcome</topic><topic>Tumor necrosis factor</topic><topic>Tumor necrosis factor- alpha</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiao, H W</creatorcontrib><creatorcontrib>Lai, X Y</creatorcontrib><creatorcontrib>Luo, Y</creatorcontrib><creatorcontrib>Shi, J M</creatorcontrib><creatorcontrib>Tan, Y M</creatorcontrib><creatorcontrib>He, J S</creatorcontrib><creatorcontrib>Xie, W Z</creatorcontrib><creatorcontrib>Li, L</creatorcontrib><creatorcontrib>Zhu, X L</creatorcontrib><creatorcontrib>Zhu, J J</creatorcontrib><creatorcontrib>Sun, J</creatorcontrib><creatorcontrib>Wei, G Q</creatorcontrib><creatorcontrib>Jin, L</creatorcontrib><creatorcontrib>Liu, L Z</creatorcontrib><creatorcontrib>Wu, K N</creatorcontrib><creatorcontrib>Yu, X H</creatorcontrib><creatorcontrib>Cai, Z</creatorcontrib><creatorcontrib>Lin, M F</creatorcontrib><creatorcontrib>Ye, X J</creatorcontrib><creatorcontrib>Huang, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Genetics Abstracts</collection><jtitle>Bone marrow transplantation (Basingstoke)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiao, H W</au><au>Lai, X Y</au><au>Luo, Y</au><au>Shi, J M</au><au>Tan, Y M</au><au>He, J S</au><au>Xie, W Z</au><au>Li, L</au><au>Zhu, X L</au><au>Zhu, J J</au><au>Sun, J</au><au>Wei, G Q</au><au>Jin, L</au><au>Liu, L Z</au><au>Wu, K N</au><au>Yu, X H</au><au>Cai, Z</au><au>Lin, M F</au><au>Ye, X J</au><au>Huang, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between TNFA, TNFB and TNFRII gene polymorphisms and outcome after unrelated hematopoietic cell transplantation in a Chinese population</atitle><jtitle>Bone marrow transplantation (Basingstoke)</jtitle><stitle>Bone Marrow Transplant</stitle><addtitle>Bone Marrow Transplant</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>46</volume><issue>3</issue><spage>400</spage><epage>407</epage><pages>400-407</pages><issn>0268-3369</issn><eissn>1476-5365</eissn><coden>BMTRE9</coden><abstract>This study aimed to analyze the association between cytokine gene polymorphisms and outcome following allogeneic hematopoietic SCT (allo-HSCT). A total of 138 unrelated donor/recipient pairs who underwent allo-HSCT from 2001 to 2009 were tested for TNFA-1031 (T>C), -863 (C>A), -857 (C>T), -238 (G>A), TNFB+252 (A>G) and TNFRII codon 196 (T>G) single nucleotide polymorphisms by multiplex SnaPshot analysis. Transplantation involving recipients and/or donors with TNFA-857 C/C genotype or TNFB+252 G allele-positivity resulted in a higher incidence of acute GVHD (aGVHD), which was independent of HLA mismatching. In multivariate analysis, TNFA-857 C/C genotype donors (relative risk (RR)=2.29,
P
=0.006) and TNFB+252 G allele-positive recipients (RR=1.789,
P
=0.036) were found to be significantly associated with an increased incidence of aGVHD. TNFA-857 C/C genotype donors (RR=3.748,
P
=0.002) and TNFB+252 G allele-positive recipients (RR=1.823,
P
=0.063) were also associated with the development of grades II–IV aGVHD. TNFRII polymorphism in recipients was also related to relapse rate, but no significant associations were found between TNFA, TNFB or TNFRII 196 genotype and cGVHD, relapse or overall survival after transplantation. These results provide the first report of an association between TNFA, TNFB and TNFRII polymorphic features and outcome of allo-HSCT in a Chinese population, and suggest an interaction between TNFA-857 and TNFB+252 genotypes and risk of aGVHD.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20548340</pmid><doi>10.1038/bmt.2010.135</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-3369 |
| ispartof | Bone marrow transplantation (Basingstoke), 2011-03, Vol.46 (3), p.400-407 |
| issn | 0268-3369 1476-5365 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_954605416 |
| source | MEDLINE; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | 631/208/726/649 631/45/127/1220 692/699/249/1529 692/700/565/545/576/1955 Adolescent Adult Alleles Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Asian Continental Ancestry Group Biological and medical sciences Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Cell Biology Child China Codons Cohort Studies Cytokines Donors Female Gene polymorphism Genetic aspects Genetic polymorphisms Genotype & phenotype Genotypes Graft vs Host Disease - etiology Graft vs Host Disease - genetics Graft-versus-host reaction Health aspects Hematology Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Hemopoiesis Histocompatibility antigen HLA Humans Internal Medicine Lymphotoxin-alpha - genetics Male Medical sciences Medicine Medicine & Public Health Middle Aged Multivariate analysis Nucleotides original-article Physiological aspects Polymorphism Polymorphism, Genetic Polymorphism, Single Nucleotide Population studies Public Health Receptors, Tumor Necrosis Factor, Type II - genetics Risk assessment Single nucleotide polymorphisms Single-nucleotide polymorphism Stem cell transplantation Stem Cells Survival Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Treatment Outcome Tumor necrosis factor Tumor necrosis factor- alpha Tumor Necrosis Factor-alpha - genetics Young Adult |
| title | Relationship between TNFA, TNFB and TNFRII gene polymorphisms and outcome after unrelated hematopoietic cell transplantation in a Chinese population |
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