Predictors of Mood Response to Acute Tryptophan Depletion: A Reanalysis
Acute tryptophan depletion (ATD) induces depressive symptoms in 50-60% of selective serotonin reuptake inhibitor (SSRI) treated, recovered depressed patients. However, no reliable predictors of mood response to ATD have been established. In the present study, individual subject data of six ATD studi...
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| Veröffentlicht in: | Neuropsychopharmacology (New York, N.Y.) N.Y.), 2002-11, Vol.27 (5), p.852-861 |
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| creator | Booij, Linda Van der Does, Willem Benkelfat, Chawki Bremner, J.Douglas Cowen, Philip J Fava, Maurizio Gillin, Christian Leyton, Marco Moore, Polly Smith, Katharine A Van der Kloot, Willem A |
| description | Acute tryptophan depletion (ATD) induces depressive symptoms in 50-60% of selective serotonin reuptake inhibitor (SSRI) treated, recovered depressed patients. However, no reliable predictors of mood response to ATD have been established. In the present study, individual subject data of six ATD studies were pooled (‘mega-analysis’) in order to investigate the mediating role of clinical, demographic and biochemical characteristics in the mood response to ATD. A procedure was developed to make different versions of the Hamilton scale comparable. Recurrent depressive episodes, female gender, prior exposure to SSRI antidepressant treatment and previous serious suicidal thoughts/attempts all appear to be independent predictors of mood response to ATD. Chronicity of illness is the most powerful predictor. Residual symptoms of depression were not found to predict response to ATD. ATD may be useful to study the mechanism of action of SSRI antidepressants and individual biological vulnerability of the serotonin system. Whether the effects of ATD represent a reversal of the action of SSRI antidepressants or individual vulnerability probably depends upon the timing of the procedure in the course of remission of a depressive episode. |
| doi_str_mv | 10.1016/S0893-133X(02)00361-5 |
| format | Article |
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However, no reliable predictors of mood response to ATD have been established. In the present study, individual subject data of six ATD studies were pooled (‘mega-analysis’) in order to investigate the mediating role of clinical, demographic and biochemical characteristics in the mood response to ATD. A procedure was developed to make different versions of the Hamilton scale comparable. Recurrent depressive episodes, female gender, prior exposure to SSRI antidepressant treatment and previous serious suicidal thoughts/attempts all appear to be independent predictors of mood response to ATD. Chronicity of illness is the most powerful predictor. Residual symptoms of depression were not found to predict response to ATD. ATD may be useful to study the mechanism of action of SSRI antidepressants and individual biological vulnerability of the serotonin system. Whether the effects of ATD represent a reversal of the action of SSRI antidepressants or individual vulnerability probably depends upon the timing of the procedure in the course of remission of a depressive episode.</description><identifier>ISSN: 0893-133X</identifier><identifier>EISSN: 1740-634X</identifier><identifier>DOI: 10.1016/S0893-133X(02)00361-5</identifier><identifier>PMID: 12431859</identifier><identifier>CODEN: NEROEW</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Affect - physiology ; Amino acids ; Biological and medical sciences ; Depression ; Depressive Disorder - blood ; Depressive Disorder - drug therapy ; Depressive Disorder - psychology ; Female ; Forecasting ; Hamilton Depression Rating Scale ; Humans ; Male ; Medical sciences ; Middle Aged ; Mood ; Mood disorders ; Psychiatric Status Rating Scales - statistics & numerical data ; Psychology. Psychoanalysis. 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Psychiatry ; Regression Analysis ; Serotonin ; Serotonin Uptake Inhibitors - therapeutic use ; Sex Factors ; Tryptophan - blood ; Tryptophan - deficiency ; Tryptophan depletion</subject><ispartof>Neuropsychopharmacology (New York, N.Y.), 2002-11, Vol.27 (5), p.852-861</ispartof><rights>2002 American College of Neuropsychopharmacology</rights><rights>2003 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Nov 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c563t-5480e71b9ee518f9f9aa7d4f5836569a5712249419cd6e27e9fc00d41c090f073</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13966278$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12431859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Booij, Linda</creatorcontrib><creatorcontrib>Van der Does, Willem</creatorcontrib><creatorcontrib>Benkelfat, Chawki</creatorcontrib><creatorcontrib>Bremner, J.Douglas</creatorcontrib><creatorcontrib>Cowen, Philip J</creatorcontrib><creatorcontrib>Fava, Maurizio</creatorcontrib><creatorcontrib>Gillin, Christian</creatorcontrib><creatorcontrib>Leyton, Marco</creatorcontrib><creatorcontrib>Moore, Polly</creatorcontrib><creatorcontrib>Smith, Katharine A</creatorcontrib><creatorcontrib>Van der Kloot, Willem A</creatorcontrib><title>Predictors of Mood Response to Acute Tryptophan Depletion: A Reanalysis</title><title>Neuropsychopharmacology (New York, N.Y.)</title><addtitle>Neuropsychopharmacology</addtitle><description>Acute tryptophan depletion (ATD) induces depressive symptoms in 50-60% of selective serotonin reuptake inhibitor (SSRI) treated, recovered depressed patients. 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| source | MEDLINE; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Adult and adolescent clinical studies Affect - physiology Amino acids Biological and medical sciences Depression Depressive Disorder - blood Depressive Disorder - drug therapy Depressive Disorder - psychology Female Forecasting Hamilton Depression Rating Scale Humans Male Medical sciences Middle Aged Mood Mood disorders Psychiatric Status Rating Scales - statistics & numerical data Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Regression Analysis Serotonin Serotonin Uptake Inhibitors - therapeutic use Sex Factors Tryptophan - blood Tryptophan - deficiency Tryptophan depletion |
| title | Predictors of Mood Response to Acute Tryptophan Depletion: A Reanalysis |
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