Efficacy of a Methylphenidate Transdermal System Versus t.i.d. Methylphenidate in a Laboratory Setting
Objective: To test the efficacy and tolerability of the methylphenidate transdermal formulation (MTS) against immediate-release methylphenidate (IR MPH) and placebo in a 12-hr analog classroom setting. Method: A total of nine boys ages 6 to 9 years, medicated with MPH for ADHD, complete a within-sub...
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| Veröffentlicht in: | Journal of attention disorders 2011-01, Vol.15 (1), p.28-35 |
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| creator | Pelham, William E. Waxmonsky, James G. Schentag, Jerome Ballow, Charles H. Panahon, Carlos J. Gnagy, Elizabeth M. Hoffman, Martin T. Burrows-MacLean, Lisa Meichenbaum, David L. Forehand, Gregory L. Fabiano, Gregory A. Tresco, Katy E. Lopez-Williams, Andy Coles, Erika K. González, Mario A. |
| description | Objective: To test the efficacy and tolerability of the methylphenidate transdermal formulation (MTS) against immediate-release methylphenidate (IR MPH) and placebo in a 12-hr analog classroom setting. Method: A total of nine boys ages 6 to 9 years, medicated with MPH for ADHD, complete a within-subject, double-blind study. For the purpose of the study, the boys are administered a dose of 20 cm2 MTS, a matched dose of IR MPH 10 mg TID, and placebo. ADHD symptoms and frequency counts of classroom rule violations and the number of math problems completed are assessed hourly, during three consecutive analog classroom sessions. Results: Findings show that, across measures and throughout the day, both treatments significantly differentiated from placebo (p < .05) but not from each other. It is also observed that the MTS produced more consistent results across the day but had a delayed onset versus IR MPH. Both medications are well tolerated with only mild reductions in sleep onset. Conclusion: The MTS demonstrates comparable efficacy and tolerability to TID IR MPH. |
| doi_str_mv | 10.1177/1087054709359163 |
| format | Article |
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Methylphenidate in a Laboratory Setting</title><source>MEDLINE</source><source>SAGE Complete A-Z List</source><creator>Pelham, William E. ; Waxmonsky, James G. ; Schentag, Jerome ; Ballow, Charles H. ; Panahon, Carlos J. ; Gnagy, Elizabeth M. ; Hoffman, Martin T. ; Burrows-MacLean, Lisa ; Meichenbaum, David L. ; Forehand, Gregory L. ; Fabiano, Gregory A. ; Tresco, Katy E. ; Lopez-Williams, Andy ; Coles, Erika K. ; González, Mario A.</creator><creatorcontrib>Pelham, William E. ; Waxmonsky, James G. ; Schentag, Jerome ; Ballow, Charles H. ; Panahon, Carlos J. ; Gnagy, Elizabeth M. ; Hoffman, Martin T. ; Burrows-MacLean, Lisa ; Meichenbaum, David L. ; Forehand, Gregory L. ; Fabiano, Gregory A. ; Tresco, Katy E. ; Lopez-Williams, Andy ; Coles, Erika K. ; González, Mario A.</creatorcontrib><description>Objective: To test the efficacy and tolerability of the methylphenidate transdermal formulation (MTS) against immediate-release methylphenidate (IR MPH) and placebo in a 12-hr analog classroom setting. Method: A total of nine boys ages 6 to 9 years, medicated with MPH for ADHD, complete a within-subject, double-blind study. For the purpose of the study, the boys are administered a dose of 20 cm2 MTS, a matched dose of IR MPH 10 mg TID, and placebo. ADHD symptoms and frequency counts of classroom rule violations and the number of math problems completed are assessed hourly, during three consecutive analog classroom sessions. Results: Findings show that, across measures and throughout the day, both treatments significantly differentiated from placebo (p < .05) but not from each other. It is also observed that the MTS produced more consistent results across the day but had a delayed onset versus IR MPH. Both medications are well tolerated with only mild reductions in sleep onset. Conclusion: The MTS demonstrates comparable efficacy and tolerability to TID IR MPH.</description><identifier>ISSN: 1087-0547</identifier><identifier>EISSN: 1557-1246</identifier><identifier>DOI: 10.1177/1087054709359163</identifier><identifier>PMID: 20439487</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Administration, Cutaneous ; Analysis of Variance ; Attention Deficit Disorder with Hyperactivity - drug therapy ; Attention Deficit Hyperactivity Disorder ; Central Nervous System Stimulants - administration & dosage ; Central Nervous System Stimulants - therapeutic use ; Child ; Child Behavior ; Children ; Comparative Analysis ; Double-Blind Method ; Drug Administration Schedule ; Drug Therapy ; Humans ; Male ; Males ; Mathematics Instruction ; Methylphenidate - administration & dosage ; Methylphenidate - therapeutic use ; Outcomes of Treatment ; Problem Solving ; Student Behavior ; Symptoms (Individual Disorders) ; Treatment Outcome ; Wechsler Intelligence Scale for Children III</subject><ispartof>Journal of attention disorders, 2011-01, Vol.15 (1), p.28-35</ispartof><rights>2011 SAGE Publications</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-2218698cc7446d79dd6f2778a306c3432e69da218cbabfefc2c6a3a7f9d902d3</citedby><cites>FETCH-LOGICAL-c421t-2218698cc7446d79dd6f2778a306c3432e69da218cbabfefc2c6a3a7f9d902d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1087054709359163$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1087054709359163$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ907849$$DView record in ERIC$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20439487$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pelham, William E.</creatorcontrib><creatorcontrib>Waxmonsky, James G.</creatorcontrib><creatorcontrib>Schentag, Jerome</creatorcontrib><creatorcontrib>Ballow, Charles H.</creatorcontrib><creatorcontrib>Panahon, Carlos J.</creatorcontrib><creatorcontrib>Gnagy, Elizabeth M.</creatorcontrib><creatorcontrib>Hoffman, Martin T.</creatorcontrib><creatorcontrib>Burrows-MacLean, Lisa</creatorcontrib><creatorcontrib>Meichenbaum, David L.</creatorcontrib><creatorcontrib>Forehand, Gregory L.</creatorcontrib><creatorcontrib>Fabiano, Gregory A.</creatorcontrib><creatorcontrib>Tresco, Katy E.</creatorcontrib><creatorcontrib>Lopez-Williams, Andy</creatorcontrib><creatorcontrib>Coles, Erika K.</creatorcontrib><creatorcontrib>González, Mario A.</creatorcontrib><title>Efficacy of a Methylphenidate Transdermal System Versus t.i.d. Methylphenidate in a Laboratory Setting</title><title>Journal of attention disorders</title><addtitle>J Atten Disord</addtitle><description>Objective: To test the efficacy and tolerability of the methylphenidate transdermal formulation (MTS) against immediate-release methylphenidate (IR MPH) and placebo in a 12-hr analog classroom setting. Method: A total of nine boys ages 6 to 9 years, medicated with MPH for ADHD, complete a within-subject, double-blind study. For the purpose of the study, the boys are administered a dose of 20 cm2 MTS, a matched dose of IR MPH 10 mg TID, and placebo. ADHD symptoms and frequency counts of classroom rule violations and the number of math problems completed are assessed hourly, during three consecutive analog classroom sessions. Results: Findings show that, across measures and throughout the day, both treatments significantly differentiated from placebo (p < .05) but not from each other. 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Methylphenidate in a Laboratory Setting</atitle><jtitle>Journal of attention disorders</jtitle><addtitle>J Atten Disord</addtitle><date>2011-01</date><risdate>2011</risdate><volume>15</volume><issue>1</issue><spage>28</spage><epage>35</epage><pages>28-35</pages><issn>1087-0547</issn><eissn>1557-1246</eissn><abstract>Objective: To test the efficacy and tolerability of the methylphenidate transdermal formulation (MTS) against immediate-release methylphenidate (IR MPH) and placebo in a 12-hr analog classroom setting. Method: A total of nine boys ages 6 to 9 years, medicated with MPH for ADHD, complete a within-subject, double-blind study. For the purpose of the study, the boys are administered a dose of 20 cm2 MTS, a matched dose of IR MPH 10 mg TID, and placebo. ADHD symptoms and frequency counts of classroom rule violations and the number of math problems completed are assessed hourly, during three consecutive analog classroom sessions. Results: Findings show that, across measures and throughout the day, both treatments significantly differentiated from placebo (p < .05) but not from each other. It is also observed that the MTS produced more consistent results across the day but had a delayed onset versus IR MPH. Both medications are well tolerated with only mild reductions in sleep onset. Conclusion: The MTS demonstrates comparable efficacy and tolerability to TID IR MPH.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>20439487</pmid><doi>10.1177/1087054709359163</doi><tpages>8</tpages></addata></record> |
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| subjects | Administration, Cutaneous Analysis of Variance Attention Deficit Disorder with Hyperactivity - drug therapy Attention Deficit Hyperactivity Disorder Central Nervous System Stimulants - administration & dosage Central Nervous System Stimulants - therapeutic use Child Child Behavior Children Comparative Analysis Double-Blind Method Drug Administration Schedule Drug Therapy Humans Male Males Mathematics Instruction Methylphenidate - administration & dosage Methylphenidate - therapeutic use Outcomes of Treatment Problem Solving Student Behavior Symptoms (Individual Disorders) Treatment Outcome Wechsler Intelligence Scale for Children III |
| title | Efficacy of a Methylphenidate Transdermal System Versus t.i.d. Methylphenidate in a Laboratory Setting |
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