Retrospective study on PET–SPECT imaging in a large cohort of myotonic dystrophy type 1 patients
The aim was to study brain involvement in myotonic dystrophy type 1 by single photon emission tomography (SPECT) and positron emission tomography (PET). 58 DM1 patients were subjected to SPECT; 17 to both SPECT and PET. SPECT patients were grouped as ‘normally perfused’ and ‘abnormally perfused’; PE...
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| Veröffentlicht in: | Neurological sciences 2010-12, Vol.31 (6), p.757-763 |
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| creator | Romeo, Vincenzo Pegoraro, E. Squarzanti, F. Sorarù, G. Ferrati, C. Ermani, M. Zucchetta, P. Chierichetti, F. Angelini, C. |
| description | The aim was to study brain involvement in myotonic dystrophy type 1 by single photon emission tomography (SPECT) and positron emission tomography (PET). 58 DM1 patients were subjected to SPECT; 17 to both SPECT and PET. SPECT patients were grouped as ‘normally perfused’ and ‘abnormally perfused’; PET patients as ‘normal performers’ and ‘abnormal performers’. To quantify hypoperfusion and/or hypometabolism, we used a semi-quantitative scale. To localize focal hypoperfusion/hypometabolism, nine cerebral areas of involvement were identified. The Chi-square, Wilcoxon, McNemar tests were used for statistics. SPECT showed abnormalities in 52/58 patients. PET showed an abnormal glucidic uptake in 15/17. Hypoperfusion was mild/moderate in 50/58 patients, mostly involving the left supratentorial areas. Abnormal glucidic uptake was mainly observed in the left frontal lobe. Abnormalities in blood perfusion and/or glucose metabolism are frequent in DM1. These abnormalities involve the left more often than the right hemisphere, the frontal lobe more than other lobes. Such abnormalities are more often cortical than subcortical. |
| doi_str_mv | 10.1007/s10072-010-0406-2 |
| format | Article |
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SPECT patients were grouped as ‘normally perfused’ and ‘abnormally perfused’; PET patients as ‘normal performers’ and ‘abnormal performers’. To quantify hypoperfusion and/or hypometabolism, we used a semi-quantitative scale. To localize focal hypoperfusion/hypometabolism, nine cerebral areas of involvement were identified. The Chi-square, Wilcoxon, McNemar tests were used for statistics. SPECT showed abnormalities in 52/58 patients. PET showed an abnormal glucidic uptake in 15/17. Hypoperfusion was mild/moderate in 50/58 patients, mostly involving the left supratentorial areas. Abnormal glucidic uptake was mainly observed in the left frontal lobe. Abnormalities in blood perfusion and/or glucose metabolism are frequent in DM1. These abnormalities involve the left more often than the right hemisphere, the frontal lobe more than other lobes. Such abnormalities are more often cortical than subcortical.</description><identifier>ISSN: 1590-1874</identifier><identifier>EISSN: 1590-3478</identifier><identifier>DOI: 10.1007/s10072-010-0406-2</identifier><identifier>PMID: 20842397</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Adult ; Brain - blood supply ; Brain - diagnostic imaging ; Brain - metabolism ; Cohort Studies ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Myotonic Dystrophy - diagnosis ; Myotonic Dystrophy - diagnostic imaging ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; Original Article ; Positron-Emission Tomography - methods ; Psychiatry ; Retrospective Studies ; Severity of Illness Index ; Tomography, Emission-Computed, Single-Photon - methods</subject><ispartof>Neurological sciences, 2010-12, Vol.31 (6), p.757-763</ispartof><rights>Springer-Verlag 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-f0f8583f6b18cf0c0071b1968115ce0f461c415edb68c1d059b9462fdad723393</citedby><cites>FETCH-LOGICAL-c468t-f0f8583f6b18cf0c0071b1968115ce0f461c415edb68c1d059b9462fdad723393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10072-010-0406-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10072-010-0406-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20842397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romeo, Vincenzo</creatorcontrib><creatorcontrib>Pegoraro, E.</creatorcontrib><creatorcontrib>Squarzanti, F.</creatorcontrib><creatorcontrib>Sorarù, G.</creatorcontrib><creatorcontrib>Ferrati, C.</creatorcontrib><creatorcontrib>Ermani, M.</creatorcontrib><creatorcontrib>Zucchetta, P.</creatorcontrib><creatorcontrib>Chierichetti, F.</creatorcontrib><creatorcontrib>Angelini, C.</creatorcontrib><title>Retrospective study on PET–SPECT imaging in a large cohort of myotonic dystrophy type 1 patients</title><title>Neurological sciences</title><addtitle>Neurol Sci</addtitle><addtitle>Neurol Sci</addtitle><description>The aim was to study brain involvement in myotonic dystrophy type 1 by single photon emission tomography (SPECT) and positron emission tomography (PET). 58 DM1 patients were subjected to SPECT; 17 to both SPECT and PET. SPECT patients were grouped as ‘normally perfused’ and ‘abnormally perfused’; PET patients as ‘normal performers’ and ‘abnormal performers’. To quantify hypoperfusion and/or hypometabolism, we used a semi-quantitative scale. To localize focal hypoperfusion/hypometabolism, nine cerebral areas of involvement were identified. The Chi-square, Wilcoxon, McNemar tests were used for statistics. SPECT showed abnormalities in 52/58 patients. PET showed an abnormal glucidic uptake in 15/17. Hypoperfusion was mild/moderate in 50/58 patients, mostly involving the left supratentorial areas. Abnormal glucidic uptake was mainly observed in the left frontal lobe. Abnormalities in blood perfusion and/or glucose metabolism are frequent in DM1. These abnormalities involve the left more often than the right hemisphere, the frontal lobe more than other lobes. Such abnormalities are more often cortical than subcortical.</description><subject>Adult</subject><subject>Brain - blood supply</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Myotonic Dystrophy - diagnosis</subject><subject>Myotonic Dystrophy - diagnostic imaging</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Positron-Emission Tomography - methods</subject><subject>Psychiatry</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Tomography, Emission-Computed, Single-Photon - methods</subject><issn>1590-1874</issn><issn>1590-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc2KFDEQx4O4uB_6AF4kePHUblW-On2UYdSFBRcdz6E7ncz2MtNpk7TQN9_BN_RJzDCjgiBekkB-9S-qfoQ8R3iNAPV1OpysAoQKBKiKPSIXKBuouKj149MbdS3OyWVKDwCAAvkTcs5AC8ab-oJ0H12OIU3O5uGroynP_ULDSO_Wmx_fvn-6W682dNi322Hc0mGkLd21ceuoDfchZho83S8hh3GwtF9SSZruF5qXyVGkU5sHN-b0lJz5dpfcs9N9RT6_XW9W76vbD-9uVm9uKyuUzpUHr6XmXnWorQdbRsMOG6URpXXghUIrULq-U9piD7LpGqGY79u-Zpw3_Iq8OuZOMXyZXcpmPyTrdrt2dGFOppFCAZMA_yVrxbFWUh_Il3-RD2GOYxnDaKglFJIXCI-QLZtM0XkzxbKzuBgEc1BkjqJMEWUOogwrNS9OwXO3d_3vil9mCsCOQCpf49bFP53_nfoTsdGdFQ</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Romeo, Vincenzo</creator><creator>Pegoraro, E.</creator><creator>Squarzanti, F.</creator><creator>Sorarù, G.</creator><creator>Ferrati, C.</creator><creator>Ermani, M.</creator><creator>Zucchetta, P.</creator><creator>Chierichetti, F.</creator><creator>Angelini, C.</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20101201</creationdate><title>Retrospective study on PET–SPECT imaging in a large cohort of myotonic dystrophy type 1 patients</title><author>Romeo, Vincenzo ; 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17 to both SPECT and PET. SPECT patients were grouped as ‘normally perfused’ and ‘abnormally perfused’; PET patients as ‘normal performers’ and ‘abnormal performers’. To quantify hypoperfusion and/or hypometabolism, we used a semi-quantitative scale. To localize focal hypoperfusion/hypometabolism, nine cerebral areas of involvement were identified. The Chi-square, Wilcoxon, McNemar tests were used for statistics. SPECT showed abnormalities in 52/58 patients. PET showed an abnormal glucidic uptake in 15/17. Hypoperfusion was mild/moderate in 50/58 patients, mostly involving the left supratentorial areas. Abnormal glucidic uptake was mainly observed in the left frontal lobe. Abnormalities in blood perfusion and/or glucose metabolism are frequent in DM1. These abnormalities involve the left more often than the right hemisphere, the frontal lobe more than other lobes. Such abnormalities are more often cortical than subcortical.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>20842397</pmid><doi>10.1007/s10072-010-0406-2</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Brain - blood supply Brain - diagnostic imaging Brain - metabolism Cohort Studies Female Humans Male Medicine Medicine & Public Health Middle Aged Myotonic Dystrophy - diagnosis Myotonic Dystrophy - diagnostic imaging Neurology Neuroradiology Neurosciences Neurosurgery Original Article Positron-Emission Tomography - methods Psychiatry Retrospective Studies Severity of Illness Index Tomography, Emission-Computed, Single-Photon - methods |
| title | Retrospective study on PET–SPECT imaging in a large cohort of myotonic dystrophy type 1 patients |
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