The mechanism of protein release from triglyceride microspheres

The purpose of this study was to reveal factors that have an impact on the protein release kinetics from triglyceride microspheres prepared by spray congealing. We investigated the effect of protein particle size, morphology and distribution on protein release from microspheres by confocal laser sca...

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Veröffentlicht in:	Journal of controlled release 2010-10, Vol.147 (2), p.202-210
Hauptverfasser:	Zaky, A., Elbakry, A., Ehmer, A., Breunig, M., Goepferich, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bovine serum albumin Cattle Confocal microscopy Drug Carriers - chemistry Drug Compounding Fluorescein-5-isothiocyanate Freeze Drying General pharmacology Kinetics Lipid microspheres Medical sciences Microscopy, Electron, Scanning Microspheres Particle distribution Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Protein release Recombinant Proteins - administration & dosage Recombinant Proteins - chemistry Release mechanism Serum Albumin, Bovine - administration & dosage Serum Albumin, Bovine - chemistry Surface Properties Thermodynamics Triglycerides - chemistry
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