Myocardial infarction in rats causes partial impairment in insulin response associated with reduced fatty acid oxidation and mitochondrial gene expression

Objective Myocardial infarction leads to contractile dysfunction. In patients with diabetes, impaired contractility has been associated with the loss of insulin effects and mitochondrial dysfunction. We assessed cardiac insulin sensitivity and mitochondrial and contractile function in rats after lig...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of thoracic and cardiovascular surgery 2010-11, Vol.140 (5), p.1160-1167
Hauptverfasser:	Amorim, Paulo A., MD, Nguyen, T. Dung, BS, Shingu, Yasushige, MD, Schwarzer, Michael, PhD, Mohr, Friedrich W., MD, PhD, Schrepper, Andrea, MS, Doenst, Torsten, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl-CoA Dehydrogenase, Long-Chain - genetics Animals Blood Glucose - metabolism Cardiothoracic Surgery Carnitine O-Palmitoyltransferase - genetics Disease Models, Animal Fatty Acids - metabolism Gene Expression Regulation Glucose Transporter Type 4 - genetics Glucose Transporter Type 4 - metabolism Insulin - metabolism Insulin Resistance - genetics Male Mitochondria, Heart - metabolism Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Myocardial Contraction - genetics Myocardial Infarction - diagnostic imaging Myocardial Infarction - genetics Myocardial Infarction - metabolism Myocardial Infarction - physiopathology Myocardium - metabolism Oxidation-Reduction p38 Mitogen-Activated Protein Kinases - metabolism Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Phosphorylation PPAR alpha - genetics Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - metabolism RNA-Binding Proteins - genetics Time Factors Transcription Factors - genetics Ultrasonography
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!