Histamine effect on melanocyte proliferation and vitiliginous keratinocyte survival
Please cite this paper as: Histamine effect on melanocyte proliferation and vitiliginous keratinocyte survival. Experimental Dermatology 2010; 19: 1073–1079. : Repigmention of vitiligo requires melanocyte proliferation and migration. Keratinocytes have been shown to play a role in this process. Dat...
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| Veröffentlicht in: | Experimental dermatology 2010-12, Vol.19 (12), p.1073-1079 |
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| description | Please cite this paper as: Histamine effect on melanocyte proliferation and vitiliginous keratinocyte survival. Experimental Dermatology 2010; 19: 1073–1079.
: Repigmention of vitiligo requires melanocyte proliferation and migration. Keratinocytes have been shown to play a role in this process. Data from this laboratory showed that bee venom (BV) stimulated melanocyte proliferation and migration as well as melanogenesis. As histamine release is associated with BV, its effect on melanocyte proliferation and migration was examined. Cultured normal human melanocytes treated with histamine were studied with and without receptor‐specific antagonists or agonists. The effect of histamine on vitiliginous keratinocytes, in cultured cells treated with a PI3K inhibitor in the presence of TNF‐α, was also examined. Histamine exerted a more significant effect on melanocyte proliferation than on melanogenesis. This occurred through the H2 receptor with complex signalling to ERK, CREB, and Akt activation, which stimulated melanocyte migration. Histamine and the H2 receptor agonist also increased survival of vitiliginous, but not normal, keratinocytes, with NF‐κB activation. Because expression levels of the H2 receptor was significantly decreased in depigmented compared to normally pigmented epidermis, in patients with vitiligo, histamine may increase the survival of vitiliginous keratinocytes. Overall, histamine stimulated the proliferation and migration of melanocytes and the vitiliginous keratinocyte survival, providing the basis for novel therapeutic approaches to vitiligo repigmentation. |
| doi_str_mv | 10.1111/j.1600-0625.2010.01133.x |
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: Repigmention of vitiligo requires melanocyte proliferation and migration. Keratinocytes have been shown to play a role in this process. Data from this laboratory showed that bee venom (BV) stimulated melanocyte proliferation and migration as well as melanogenesis. As histamine release is associated with BV, its effect on melanocyte proliferation and migration was examined. Cultured normal human melanocytes treated with histamine were studied with and without receptor‐specific antagonists or agonists. The effect of histamine on vitiliginous keratinocytes, in cultured cells treated with a PI3K inhibitor in the presence of TNF‐α, was also examined. Histamine exerted a more significant effect on melanocyte proliferation than on melanogenesis. This occurred through the H2 receptor with complex signalling to ERK, CREB, and Akt activation, which stimulated melanocyte migration. Histamine and the H2 receptor agonist also increased survival of vitiliginous, but not normal, keratinocytes, with NF‐κB activation. Because expression levels of the H2 receptor was significantly decreased in depigmented compared to normally pigmented epidermis, in patients with vitiligo, histamine may increase the survival of vitiliginous keratinocytes. Overall, histamine stimulated the proliferation and migration of melanocytes and the vitiliginous keratinocyte survival, providing the basis for novel therapeutic approaches to vitiligo repigmentation.</description><identifier>ISSN: 0906-6705</identifier><identifier>EISSN: 1600-0625</identifier><identifier>DOI: 10.1111/j.1600-0625.2010.01133.x</identifier><identifier>PMID: 21054556</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>1-Phosphatidylinositol 3-kinase ; Adolescent ; Adult ; Aged ; AKT protein ; Antagonists ; Biological and medical sciences ; Cell Movement - drug effects ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Cells, Cultured ; Child ; Cyclic AMP response element-binding protein ; Data processing ; Dermatology ; Dose-Response Relationship, Drug ; Epidermis ; Epidermis - metabolism ; Epidermis - pathology ; Extracellular signal-regulated kinase ; Female ; H2 receptor ; Histamine ; Histamine - pharmacology ; Histamine Agonists - pharmacology ; Histamine H2 Antagonists - pharmacology ; Histamine H2 receptors ; Humans ; Keratinocytes ; Keratinocytes - drug effects ; Keratinocytes - metabolism ; Keratinocytes - pathology ; Leukocyte migration ; Male ; Medical sciences ; Melanins - biosynthesis ; melanocyte ; Melanocytes ; Melanocytes - cytology ; Melanocytes - drug effects ; Melanocytes - metabolism ; Middle Aged ; Migration ; NF- Kappa B protein ; NF-kappa B - metabolism ; Phosphorylation - drug effects ; Pigmentary diseases of the skin ; Receptors, Histamine H2 - metabolism ; Signal Transduction - drug effects ; Signal Transduction - physiology ; Survival ; Tumor necrosis factor- alpha ; Venom ; vitiliginous keratinocyte ; Vitiligo ; Vitiligo - metabolism ; Vitiligo - pathology ; vitiligo repigmentation ; Young Adult</subject><ispartof>Experimental dermatology, 2010-12, Vol.19 (12), p.1073-1079</ispartof><rights>2010 John Wiley & Sons A/S</rights><rights>2015 INIST-CNRS</rights><rights>2010 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4683-124fe594897a7603280affbeef6c98a66d08d6dbb9a734931642bd6c0fb8b3263</citedby><cites>FETCH-LOGICAL-c4683-124fe594897a7603280affbeef6c98a66d08d6dbb9a734931642bd6c0fb8b3263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0625.2010.01133.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0625.2010.01133.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23503478$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21054556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Nan-Hyung</creatorcontrib><creatorcontrib>Lee, Ai-Young</creatorcontrib><title>Histamine effect on melanocyte proliferation and vitiliginous keratinocyte survival</title><title>Experimental dermatology</title><addtitle>Exp Dermatol</addtitle><description>Please cite this paper as: Histamine effect on melanocyte proliferation and vitiliginous keratinocyte survival. Experimental Dermatology 2010; 19: 1073–1079.
: Repigmention of vitiligo requires melanocyte proliferation and migration. Keratinocytes have been shown to play a role in this process. Data from this laboratory showed that bee venom (BV) stimulated melanocyte proliferation and migration as well as melanogenesis. As histamine release is associated with BV, its effect on melanocyte proliferation and migration was examined. Cultured normal human melanocytes treated with histamine were studied with and without receptor‐specific antagonists or agonists. The effect of histamine on vitiliginous keratinocytes, in cultured cells treated with a PI3K inhibitor in the presence of TNF‐α, was also examined. Histamine exerted a more significant effect on melanocyte proliferation than on melanogenesis. This occurred through the H2 receptor with complex signalling to ERK, CREB, and Akt activation, which stimulated melanocyte migration. Histamine and the H2 receptor agonist also increased survival of vitiliginous, but not normal, keratinocytes, with NF‐κB activation. Because expression levels of the H2 receptor was significantly decreased in depigmented compared to normally pigmented epidermis, in patients with vitiligo, histamine may increase the survival of vitiliginous keratinocytes. Overall, histamine stimulated the proliferation and migration of melanocytes and the vitiliginous keratinocyte survival, providing the basis for novel therapeutic approaches to vitiligo repigmentation.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>AKT protein</subject><subject>Antagonists</subject><subject>Biological and medical sciences</subject><subject>Cell Movement - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cells, Cultured</subject><subject>Child</subject><subject>Cyclic AMP response element-binding protein</subject><subject>Data processing</subject><subject>Dermatology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Epidermis</subject><subject>Epidermis - metabolism</subject><subject>Epidermis - pathology</subject><subject>Extracellular signal-regulated kinase</subject><subject>Female</subject><subject>H2 receptor</subject><subject>Histamine</subject><subject>Histamine - pharmacology</subject><subject>Histamine Agonists - pharmacology</subject><subject>Histamine H2 Antagonists - pharmacology</subject><subject>Histamine H2 receptors</subject><subject>Humans</subject><subject>Keratinocytes</subject><subject>Keratinocytes - drug effects</subject><subject>Keratinocytes - metabolism</subject><subject>Keratinocytes - pathology</subject><subject>Leukocyte migration</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanins - biosynthesis</subject><subject>melanocyte</subject><subject>Melanocytes</subject><subject>Melanocytes - cytology</subject><subject>Melanocytes - drug effects</subject><subject>Melanocytes - metabolism</subject><subject>Middle Aged</subject><subject>Migration</subject><subject>NF- Kappa B protein</subject><subject>NF-kappa B - metabolism</subject><subject>Phosphorylation - drug effects</subject><subject>Pigmentary diseases of the skin</subject><subject>Receptors, Histamine H2 - metabolism</subject><subject>Signal Transduction - drug effects</subject><subject>Signal Transduction - physiology</subject><subject>Survival</subject><subject>Tumor necrosis factor- alpha</subject><subject>Venom</subject><subject>vitiliginous keratinocyte</subject><subject>Vitiligo</subject><subject>Vitiligo - metabolism</subject><subject>Vitiligo - pathology</subject><subject>vitiligo repigmentation</subject><subject>Young Adult</subject><issn>0906-6705</issn><issn>1600-0625</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkstuEzEYhS0EomnhFdBsEKsJv69jL1ig0qagiEoUBDvL47GR07kUe5Imb19PE8KSemPL5zv20bERKjDMcR7vV3MsAEoQhM8J5F3AmNL59hmaHYXnaAYKRCkq4CfoNKUVAK5oxV-iE4KBM87FDN1chTSaLvSucN47OxZDX3SuNf1gd6Mr7uLQBu-iGUMWTN8UmzCGNvwO_bBOxe2jcmDTOm7CxrSv0Atv2uReH-Yz9OPy4vv5Vbm8Xnw-_7gsLROSlpgw77hiUlWmEkCJBON97ZwXVkkjRAOyEU1dK1NRpigWjNSNsOBrWVMi6Bl6tz83h_yzdmnUXUjWtTm8y-G04iyXQVT1X1KCZEKAIpmUe9LGIaXovL6LoTNxpzHoqXu90lPFeqpYT93rx-71NlvfHC5Z151rjsa_ZWfg7QEwyZrWR9PbkP5xlANllczchz13H1q3e3IAffHr07TK_nLvz0_rtke_ibdaTB9A__y60Ep8u1mCXOgv9AEb267r</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>Kim, Nan-Hyung</creator><creator>Lee, Ai-Young</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SS</scope></search><sort><creationdate>201012</creationdate><title>Histamine effect on melanocyte proliferation and vitiliginous keratinocyte survival</title><author>Kim, Nan-Hyung ; Lee, Ai-Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4683-124fe594897a7603280affbeef6c98a66d08d6dbb9a734931642bd6c0fb8b3263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>AKT protein</topic><topic>Antagonists</topic><topic>Biological and medical sciences</topic><topic>Cell Movement - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Cells, Cultured</topic><topic>Child</topic><topic>Cyclic AMP response element-binding protein</topic><topic>Data processing</topic><topic>Dermatology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Epidermis</topic><topic>Epidermis - metabolism</topic><topic>Epidermis - pathology</topic><topic>Extracellular signal-regulated kinase</topic><topic>Female</topic><topic>H2 receptor</topic><topic>Histamine</topic><topic>Histamine - pharmacology</topic><topic>Histamine Agonists - pharmacology</topic><topic>Histamine H2 Antagonists - pharmacology</topic><topic>Histamine H2 receptors</topic><topic>Humans</topic><topic>Keratinocytes</topic><topic>Keratinocytes - drug effects</topic><topic>Keratinocytes - metabolism</topic><topic>Keratinocytes - pathology</topic><topic>Leukocyte migration</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melanins - biosynthesis</topic><topic>melanocyte</topic><topic>Melanocytes</topic><topic>Melanocytes - cytology</topic><topic>Melanocytes - drug effects</topic><topic>Melanocytes - metabolism</topic><topic>Middle Aged</topic><topic>Migration</topic><topic>NF- Kappa B protein</topic><topic>NF-kappa B - metabolism</topic><topic>Phosphorylation - drug effects</topic><topic>Pigmentary diseases of the skin</topic><topic>Receptors, Histamine H2 - metabolism</topic><topic>Signal Transduction - drug effects</topic><topic>Signal Transduction - physiology</topic><topic>Survival</topic><topic>Tumor necrosis factor- alpha</topic><topic>Venom</topic><topic>vitiliginous keratinocyte</topic><topic>Vitiligo</topic><topic>Vitiligo - metabolism</topic><topic>Vitiligo - pathology</topic><topic>vitiligo repigmentation</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Nan-Hyung</creatorcontrib><creatorcontrib>Lee, Ai-Young</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Entomology Abstracts (Full archive)</collection><jtitle>Experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Nan-Hyung</au><au>Lee, Ai-Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histamine effect on melanocyte proliferation and vitiliginous keratinocyte survival</atitle><jtitle>Experimental dermatology</jtitle><addtitle>Exp Dermatol</addtitle><date>2010-12</date><risdate>2010</risdate><volume>19</volume><issue>12</issue><spage>1073</spage><epage>1079</epage><pages>1073-1079</pages><issn>0906-6705</issn><eissn>1600-0625</eissn><abstract>Please cite this paper as: Histamine effect on melanocyte proliferation and vitiliginous keratinocyte survival. Experimental Dermatology 2010; 19: 1073–1079.
: Repigmention of vitiligo requires melanocyte proliferation and migration. Keratinocytes have been shown to play a role in this process. Data from this laboratory showed that bee venom (BV) stimulated melanocyte proliferation and migration as well as melanogenesis. As histamine release is associated with BV, its effect on melanocyte proliferation and migration was examined. Cultured normal human melanocytes treated with histamine were studied with and without receptor‐specific antagonists or agonists. The effect of histamine on vitiliginous keratinocytes, in cultured cells treated with a PI3K inhibitor in the presence of TNF‐α, was also examined. Histamine exerted a more significant effect on melanocyte proliferation than on melanogenesis. This occurred through the H2 receptor with complex signalling to ERK, CREB, and Akt activation, which stimulated melanocyte migration. Histamine and the H2 receptor agonist also increased survival of vitiliginous, but not normal, keratinocytes, with NF‐κB activation. Because expression levels of the H2 receptor was significantly decreased in depigmented compared to normally pigmented epidermis, in patients with vitiligo, histamine may increase the survival of vitiliginous keratinocytes. Overall, histamine stimulated the proliferation and migration of melanocytes and the vitiliginous keratinocyte survival, providing the basis for novel therapeutic approaches to vitiligo repigmentation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21054556</pmid><doi>10.1111/j.1600-0625.2010.01133.x</doi><tpages>7</tpages></addata></record> |
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| subjects | 1-Phosphatidylinositol 3-kinase Adolescent Adult Aged AKT protein Antagonists Biological and medical sciences Cell Movement - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Child Cyclic AMP response element-binding protein Data processing Dermatology Dose-Response Relationship, Drug Epidermis Epidermis - metabolism Epidermis - pathology Extracellular signal-regulated kinase Female H2 receptor Histamine Histamine - pharmacology Histamine Agonists - pharmacology Histamine H2 Antagonists - pharmacology Histamine H2 receptors Humans Keratinocytes Keratinocytes - drug effects Keratinocytes - metabolism Keratinocytes - pathology Leukocyte migration Male Medical sciences Melanins - biosynthesis melanocyte Melanocytes Melanocytes - cytology Melanocytes - drug effects Melanocytes - metabolism Middle Aged Migration NF- Kappa B protein NF-kappa B - metabolism Phosphorylation - drug effects Pigmentary diseases of the skin Receptors, Histamine H2 - metabolism Signal Transduction - drug effects Signal Transduction - physiology Survival Tumor necrosis factor- alpha Venom vitiliginous keratinocyte Vitiligo Vitiligo - metabolism Vitiligo - pathology vitiligo repigmentation Young Adult |
| title | Histamine effect on melanocyte proliferation and vitiliginous keratinocyte survival |
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