Anorexia nervosa, osteoporosis and circulating leptin: the missing link
Summary Methods: Leptin levels were measured in 103 consecutive women with anorexia nervosa. Results: Spine BMD and Z-score values were found to be significantly lower in the low tertile compared with the highest tertile. Duration of amenorrhea and leptin level accounted for 27% of the variance in l...
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| description | Summary Methods: Leptin levels were measured in 103 consecutive women with anorexia nervosa. Results: Spine BMD and Z-score values were found to be significantly lower in the low tertile compared with the highest tertile. Duration of amenorrhea and leptin level accounted for 27% of the variance in lumbar spine BMD. Introduction The purpose of this study was to assess leptin levels and other biological variables in a population of anorexia nervosa patients. Methods Leptin levels were measured consecutively in 103 women with anorexia nervosa (AN) with a mean age of 24.9 ± 7.4 years. Osteodensitometry was also performed by dual energy X-ray absorptiometry (DXA). Results Spine bone mineral density (BMD) and Z-score values were found to be significantly lower in the low tertile compared with the highest tertile. Duration of amenorrhea and leptin level accounted for 27% of the variance in lumbar spine BMD. The mean leptin level was 3.9 ± 4.6 ng/mL (normal values, 3.5-11 ng/mL). The distribution of leptin values was not a Gaussian distribution, and a log-transformed was therefore performed. A significant correlation was found between leptin level and spinal BMD (r = 0.3; p = 0.002); significant correlations were observed for both femoral neck and total hip BMDs. When leptin level values were divided into tertiles, spine BMD and Z-score values were found to be significantly lower in the lower tertile (p = 0.04 and p = 0.02) compared with the highest tertile. For femoral neck BMDs, the T-score was slightly lower between low and high tertile, but the difference was not statistically significant (p = 0.07). When multivariate analyses were performed, two independent factors which could possibly account for the variance in spinal BMDs were found. Duration of amenorrhea and leptin level accounted for 27% of the variance (p |
| doi_str_mv | 10.1007/s00198-009-1120-x |
| format | Article |
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Results: Spine BMD and Z-score values were found to be significantly lower in the low tertile compared with the highest tertile. Duration of amenorrhea and leptin level accounted for 27% of the variance in lumbar spine BMD. Introduction The purpose of this study was to assess leptin levels and other biological variables in a population of anorexia nervosa patients. Methods Leptin levels were measured consecutively in 103 women with anorexia nervosa (AN) with a mean age of 24.9 ± 7.4 years. Osteodensitometry was also performed by dual energy X-ray absorptiometry (DXA). Results Spine bone mineral density (BMD) and Z-score values were found to be significantly lower in the low tertile compared with the highest tertile. Duration of amenorrhea and leptin level accounted for 27% of the variance in lumbar spine BMD. The mean leptin level was 3.9 ± 4.6 ng/mL (normal values, 3.5-11 ng/mL). The distribution of leptin values was not a Gaussian distribution, and a log-transformed was therefore performed. A significant correlation was found between leptin level and spinal BMD (r = 0.3; p = 0.002); significant correlations were observed for both femoral neck and total hip BMDs. When leptin level values were divided into tertiles, spine BMD and Z-score values were found to be significantly lower in the lower tertile (p = 0.04 and p = 0.02) compared with the highest tertile. For femoral neck BMDs, the T-score was slightly lower between low and high tertile, but the difference was not statistically significant (p = 0.07). When multivariate analyses were performed, two independent factors which could possibly account for the variance in spinal BMDs were found. Duration of amenorrhea and leptin level accounted for 27% of the variance (p < 0.0001). Conclusion The mechanisms underlying bone loss in AN patients remain unclear and complex, involving hypoestrogenia as well as nutritional factors such as insulin-like growth factor and leptin.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-009-1120-x</identifier><identifier>PMID: 20052458</identifier><language>eng</language><publisher>London: London : Springer-Verlag</publisher><subject>Absorptiometry, Photon - methods ; Adolescent ; Adult ; Adult and adolescent clinical studies ; Amenorrhea - blood ; Amenorrhea - etiology ; Anorexia ; Anorexia nervosa ; Anorexia Nervosa - blood ; Anorexia Nervosa - complications ; Biological and medical sciences ; Bone density ; Bone Density - physiology ; Diseases of the osteoarticular system ; Eating behavior disorders ; Endocrinology ; Female ; Femur Neck - physiopathology ; Hip Joint - physiopathology ; Hormones ; Humans ; leptin ; Leptin - blood ; Lumbar Vertebrae - physiopathology ; Medical sciences ; Medicine ; Medicine & Public Health ; Original Article ; Orthopedics ; Osteoporosis ; Osteoporosis - blood ; Osteoporosis - etiology ; Osteoporosis. Osteomalacia. Paget disease ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Rheumatology ; Spine ; Womens health ; Young Adult</subject><ispartof>Osteoporosis international, 2010-10, Vol.21 (10), p.1715-1722</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2009</rights><rights>2015 INIST-CNRS</rights><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-2e0fa60da3a5458bbc56a32dc3deb6854b0f51f52f4a7ddf4d1b4817a54b6a233</citedby><cites>FETCH-LOGICAL-c456t-2e0fa60da3a5458bbc56a32dc3deb6854b0f51f52f4a7ddf4d1b4817a54b6a233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-009-1120-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-009-1120-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23247582$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20052458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Legroux-Gérot, I</creatorcontrib><creatorcontrib>Vignau, J</creatorcontrib><creatorcontrib>Biver, E</creatorcontrib><creatorcontrib>Pigny, P</creatorcontrib><creatorcontrib>Collier, F</creatorcontrib><creatorcontrib>Marchandise, X</creatorcontrib><creatorcontrib>Duquesnoy, B</creatorcontrib><creatorcontrib>Cortet, B</creatorcontrib><title>Anorexia nervosa, osteoporosis and circulating leptin: the missing link</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>Summary Methods: Leptin levels were measured in 103 consecutive women with anorexia nervosa. Results: Spine BMD and Z-score values were found to be significantly lower in the low tertile compared with the highest tertile. Duration of amenorrhea and leptin level accounted for 27% of the variance in lumbar spine BMD. Introduction The purpose of this study was to assess leptin levels and other biological variables in a population of anorexia nervosa patients. Methods Leptin levels were measured consecutively in 103 women with anorexia nervosa (AN) with a mean age of 24.9 ± 7.4 years. Osteodensitometry was also performed by dual energy X-ray absorptiometry (DXA). Results Spine bone mineral density (BMD) and Z-score values were found to be significantly lower in the low tertile compared with the highest tertile. Duration of amenorrhea and leptin level accounted for 27% of the variance in lumbar spine BMD. The mean leptin level was 3.9 ± 4.6 ng/mL (normal values, 3.5-11 ng/mL). The distribution of leptin values was not a Gaussian distribution, and a log-transformed was therefore performed. A significant correlation was found between leptin level and spinal BMD (r = 0.3; p = 0.002); significant correlations were observed for both femoral neck and total hip BMDs. When leptin level values were divided into tertiles, spine BMD and Z-score values were found to be significantly lower in the lower tertile (p = 0.04 and p = 0.02) compared with the highest tertile. For femoral neck BMDs, the T-score was slightly lower between low and high tertile, but the difference was not statistically significant (p = 0.07). When multivariate analyses were performed, two independent factors which could possibly account for the variance in spinal BMDs were found. Duration of amenorrhea and leptin level accounted for 27% of the variance (p < 0.0001). Conclusion The mechanisms underlying bone loss in AN patients remain unclear and complex, involving hypoestrogenia as well as nutritional factors such as insulin-like growth factor and leptin.</description><subject>Absorptiometry, Photon - methods</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Amenorrhea - blood</subject><subject>Amenorrhea - etiology</subject><subject>Anorexia</subject><subject>Anorexia nervosa</subject><subject>Anorexia Nervosa - blood</subject><subject>Anorexia Nervosa - complications</subject><subject>Biological and medical sciences</subject><subject>Bone density</subject><subject>Bone Density - physiology</subject><subject>Diseases of the osteoarticular system</subject><subject>Eating behavior disorders</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Femur Neck - physiopathology</subject><subject>Hip Joint - physiopathology</subject><subject>Hormones</subject><subject>Humans</subject><subject>leptin</subject><subject>Leptin - blood</subject><subject>Lumbar Vertebrae - physiopathology</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteoporosis</subject><subject>Osteoporosis - blood</subject><subject>Osteoporosis - etiology</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Rheumatology</subject><subject>Spine</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUtv1DAUhS1ERYfCD2ADERJi08D1O2FXVdAiVWIBldhZN449pGTsqZ2g4d_XQwYqsYDVlezv3Mc5hDyj8IYC6LcZgLZNDdDWlDKodw_IigrOa9Yq-ZCsoOW6bgX9ekwe53wDRdO2-hE5ZgCSCdmsyMVZiMntBqyCSz9ixtMq5snFbUwxD7nC0Fd2SHYecRrCuhrdttR31fTNVZsh519vQ_j-hBx5HLN7eqgn5PrD-y_nl_XVp4uP52dXtRVSTTVz4FFBjxxlmd91VirkrLe8d51qpOjAS-ol8wJ133vR0040VBe6U8g4PyGvl77bFG9nlydTtrBuHDG4OGfTSqGKK03zX1JLUUCpVCFf_kXexDmFckaBgFHNpC4QXSBbjMnJebNNwwbTT0PB7NMwSxqmpGH2aZhd0Tw_NJ67jev_KH7bX4BXBwCzxdEnDHbI9xxnQsuGFY4tXC5fYe3S_Yb_mv5iEXmMBtepNL7-zIDyvT1SMMXvAJtTqwA</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Legroux-Gérot, I</creator><creator>Vignau, J</creator><creator>Biver, E</creator><creator>Pigny, P</creator><creator>Collier, F</creator><creator>Marchandise, X</creator><creator>Duquesnoy, B</creator><creator>Cortet, B</creator><general>London : Springer-Verlag</general><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20101001</creationdate><title>Anorexia nervosa, osteoporosis and circulating leptin: the missing link</title><author>Legroux-Gérot, I ; Vignau, J ; Biver, E ; Pigny, P ; Collier, F ; Marchandise, X ; Duquesnoy, B ; Cortet, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-2e0fa60da3a5458bbc56a32dc3deb6854b0f51f52f4a7ddf4d1b4817a54b6a233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Absorptiometry, Photon - methods</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Amenorrhea - blood</topic><topic>Amenorrhea - etiology</topic><topic>Anorexia</topic><topic>Anorexia nervosa</topic><topic>Anorexia Nervosa - blood</topic><topic>Anorexia Nervosa - complications</topic><topic>Biological and medical sciences</topic><topic>Bone density</topic><topic>Bone Density - physiology</topic><topic>Diseases of the osteoarticular system</topic><topic>Eating behavior disorders</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Femur Neck - physiopathology</topic><topic>Hip Joint - physiopathology</topic><topic>Hormones</topic><topic>Humans</topic><topic>leptin</topic><topic>Leptin - blood</topic><topic>Lumbar Vertebrae - physiopathology</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteoporosis</topic><topic>Osteoporosis - blood</topic><topic>Osteoporosis - etiology</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Rheumatology</topic><topic>Spine</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Legroux-Gérot, I</creatorcontrib><creatorcontrib>Vignau, J</creatorcontrib><creatorcontrib>Biver, E</creatorcontrib><creatorcontrib>Pigny, P</creatorcontrib><creatorcontrib>Collier, F</creatorcontrib><creatorcontrib>Marchandise, X</creatorcontrib><creatorcontrib>Duquesnoy, B</creatorcontrib><creatorcontrib>Cortet, B</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Legroux-Gérot, I</au><au>Vignau, J</au><au>Biver, E</au><au>Pigny, P</au><au>Collier, F</au><au>Marchandise, X</au><au>Duquesnoy, B</au><au>Cortet, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anorexia nervosa, osteoporosis and circulating leptin: the missing link</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>21</volume><issue>10</issue><spage>1715</spage><epage>1722</epage><pages>1715-1722</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Summary Methods: Leptin levels were measured in 103 consecutive women with anorexia nervosa. Results: Spine BMD and Z-score values were found to be significantly lower in the low tertile compared with the highest tertile. Duration of amenorrhea and leptin level accounted for 27% of the variance in lumbar spine BMD. Introduction The purpose of this study was to assess leptin levels and other biological variables in a population of anorexia nervosa patients. Methods Leptin levels were measured consecutively in 103 women with anorexia nervosa (AN) with a mean age of 24.9 ± 7.4 years. Osteodensitometry was also performed by dual energy X-ray absorptiometry (DXA). Results Spine bone mineral density (BMD) and Z-score values were found to be significantly lower in the low tertile compared with the highest tertile. Duration of amenorrhea and leptin level accounted for 27% of the variance in lumbar spine BMD. The mean leptin level was 3.9 ± 4.6 ng/mL (normal values, 3.5-11 ng/mL). The distribution of leptin values was not a Gaussian distribution, and a log-transformed was therefore performed. A significant correlation was found between leptin level and spinal BMD (r = 0.3; p = 0.002); significant correlations were observed for both femoral neck and total hip BMDs. When leptin level values were divided into tertiles, spine BMD and Z-score values were found to be significantly lower in the lower tertile (p = 0.04 and p = 0.02) compared with the highest tertile. For femoral neck BMDs, the T-score was slightly lower between low and high tertile, but the difference was not statistically significant (p = 0.07). When multivariate analyses were performed, two independent factors which could possibly account for the variance in spinal BMDs were found. Duration of amenorrhea and leptin level accounted for 27% of the variance (p < 0.0001). Conclusion The mechanisms underlying bone loss in AN patients remain unclear and complex, involving hypoestrogenia as well as nutritional factors such as insulin-like growth factor and leptin.</abstract><cop>London</cop><pub>London : Springer-Verlag</pub><pmid>20052458</pmid><doi>10.1007/s00198-009-1120-x</doi><tpages>8</tpages></addata></record> |
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| subjects | Absorptiometry, Photon - methods Adolescent Adult Adult and adolescent clinical studies Amenorrhea - blood Amenorrhea - etiology Anorexia Anorexia nervosa Anorexia Nervosa - blood Anorexia Nervosa - complications Biological and medical sciences Bone density Bone Density - physiology Diseases of the osteoarticular system Eating behavior disorders Endocrinology Female Femur Neck - physiopathology Hip Joint - physiopathology Hormones Humans leptin Leptin - blood Lumbar Vertebrae - physiopathology Medical sciences Medicine Medicine & Public Health Original Article Orthopedics Osteoporosis Osteoporosis - blood Osteoporosis - etiology Osteoporosis. Osteomalacia. Paget disease Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rheumatology Spine Womens health Young Adult |
| title | Anorexia nervosa, osteoporosis and circulating leptin: the missing link |
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