Neuropsychiatric symptoms are associated with increased risks of progression to dementia: a 2-year prospective study of 321 Chinese older persons with mild cognitive impairment
studies have suggested that neuropsychiatric (NP) symptoms influence the development of dementia among older adults. But, the results are inconsistent and there is limited information about NP symptoms in population-based samples. to explore the association between NP symptoms and risk of cognitive...
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| creator | Chan, Wai Chi Lam, Linda C W Tam, Cindy W C Lui, Victor W C Leung, Grace T Y Lee, Allen T C Chan, Sandra S M Fung, Ada W T Chiu, Helen F K Chan, Wai Man |
| description | studies have suggested that neuropsychiatric (NP) symptoms influence the development of dementia among older adults. But, the results are inconsistent and there is limited information about NP symptoms in population-based samples.
to explore the association between NP symptoms and risk of cognitive decline in Chinese older persons residing in the community.
prospective study.
community sample.
a total of 321 community-dwelling Chinese older persons aged 60 or over with mild cognitive impairment participated in the study.
at baseline, each subject was assessed with Clinical Dementia Rating (CDR), Mini-Mental State Examination, list learning and delayed recall, and Category Verbal Fluency Test. Severity of NP symptoms was evaluated with Neuropsychiatric Inventory (NPI). Global cognitive status at the end of 2-year study period was determined by CDR.
at baseline, 40.5% of participants exhibited one or more NP symptoms (NPI total score ≥ 1). Night-time behaviours (22.1%), depression (16.8%), apathy (14.0%) and anxiety (12.8%) were the most common NP symptoms. At the end of 2-year follow-up, 27.5% of participants with depression at baseline developed dementia, compared with 14.8% of those without depression (χ² = 4.90, P= 0.03). Aberrant motor behaviour was also significantly associated with deterioration in cognition (χ² = 5.84, P= 0.02), although it was an infrequent occurrence. On logistic regression analysis, only depression at baseline was shown to be a risk factor for progression to dementia (OR= 2.40, 95% CI 1.05-5.46, P= 0.04).
depression in non-demented older persons may represent an independent dimension reflecting early neuronal degeneration. Further studies should be conducted to assess whether effective management of NP symptoms exerts beneficial effects on cognitive function. |
| doi_str_mv | 10.1093/ageing/afq151 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_954598992</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A252385243</galeid><sourcerecordid>A252385243</sourcerecordid><originalsourceid>FETCH-LOGICAL-c492t-b840697cb20f51db41e34c02a467916d30b74a95c4b2c70e0a1425bc501bc2483</originalsourceid><addsrcrecordid>eNqFksFu1DAQhiMEotvCkSuyuHAKtR07sblVKyhIFb3A2XKc2axLEqceB8hb8Yh42QISl5VGGo38zXg0_18ULxh9w6iuLm0Pfuov7e6eSfao2DBRq5KrSjwuNpRSXtKG67PiHPEul5nhT4szzhitpVSb4ucnWGKYcXV7b1P0juA6zimMSGwEYhGDyw_Qke8-7YmfXASLuYwevyIJOzLH0EdA9GEiKZAORpiSt2-JJbxcwcYDgTO45L8BwbR066Gt4oxs934CBBKGDjIGEcOEx49GP3TEhX7yv9v8OFsfD5OfFU92dkB4_pAvii_v333efihvbq8_bq9uSic0T2WrBK1141pOd5J1rWBQCUe5FXWjWd1VtG2E1dKJlruGArVMcNk6SVnruFDVRfH6ODdvf78AJjN6dDAMdoKwoNFSSK205qdJ2jBZ5ThJqiyJ1rXSp8msoBaskZl89R95F5Y45dMYJZRSkuoDVB6h3g5gsohhSvAjuTAM0IPJh9vemisueaUkF9U_3mXpMMLOzNGPNq6GUXOwnTnazhxtl_mXD0ss7QjdX_qPz6pfrqLWDQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>848885095</pqid></control><display><type>article</type><title>Neuropsychiatric symptoms are associated with increased risks of progression to dementia: a 2-year prospective study of 321 Chinese older persons with mild cognitive impairment</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Chan, Wai Chi ; Lam, Linda C W ; Tam, Cindy W C ; Lui, Victor W C ; Leung, Grace T Y ; Lee, Allen T C ; Chan, Sandra S M ; Fung, Ada W T ; Chiu, Helen F K ; Chan, Wai Man</creator><creatorcontrib>Chan, Wai Chi ; Lam, Linda C W ; Tam, Cindy W C ; Lui, Victor W C ; Leung, Grace T Y ; Lee, Allen T C ; Chan, Sandra S M ; Fung, Ada W T ; Chiu, Helen F K ; Chan, Wai Man</creatorcontrib><description>studies have suggested that neuropsychiatric (NP) symptoms influence the development of dementia among older adults. But, the results are inconsistent and there is limited information about NP symptoms in population-based samples.
to explore the association between NP symptoms and risk of cognitive decline in Chinese older persons residing in the community.
prospective study.
community sample.
a total of 321 community-dwelling Chinese older persons aged 60 or over with mild cognitive impairment participated in the study.
at baseline, each subject was assessed with Clinical Dementia Rating (CDR), Mini-Mental State Examination, list learning and delayed recall, and Category Verbal Fluency Test. Severity of NP symptoms was evaluated with Neuropsychiatric Inventory (NPI). Global cognitive status at the end of 2-year study period was determined by CDR.
at baseline, 40.5% of participants exhibited one or more NP symptoms (NPI total score ≥ 1). Night-time behaviours (22.1%), depression (16.8%), apathy (14.0%) and anxiety (12.8%) were the most common NP symptoms. At the end of 2-year follow-up, 27.5% of participants with depression at baseline developed dementia, compared with 14.8% of those without depression (χ² = 4.90, P= 0.03). Aberrant motor behaviour was also significantly associated with deterioration in cognition (χ² = 5.84, P= 0.02), although it was an infrequent occurrence. On logistic regression analysis, only depression at baseline was shown to be a risk factor for progression to dementia (OR= 2.40, 95% CI 1.05-5.46, P= 0.04).
depression in non-demented older persons may represent an independent dimension reflecting early neuronal degeneration. Further studies should be conducted to assess whether effective management of NP symptoms exerts beneficial effects on cognitive function.</description><identifier>ISSN: 0002-0729</identifier><identifier>EISSN: 1468-2834</identifier><identifier>DOI: 10.1093/ageing/afq151</identifier><identifier>PMID: 21106558</identifier><identifier>CODEN: AANGAH</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Aged ; Aged patients ; Aged, 80 and over ; Anxiety-Depression ; Asian people ; Care and treatment ; China ; Cognition Disorders - complications ; Cognition Disorders - diagnosis ; Cognition Disorders - ethnology ; Cognitive ability ; Cognitive impairment ; Dementia ; Dementia - epidemiology ; Depression - complications ; Depression - diagnosis ; Depression - ethnology ; Development and progression ; Disease Progression ; Elderly patients ; Elderly people ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Male ; Mental depression ; Nerve Degeneration - complications ; Nerve Degeneration - diagnosis ; Nerve Degeneration - ethnology ; Neurodegeneration ; Neuropsychiatric symptoms ; Neuropsychological Tests ; Older people ; Prognosis ; Prospective Studies ; Psychiatry ; Psychological aspects ; Regression Analysis ; Risk Factors ; Symptoms</subject><ispartof>Age and ageing, 2011-01, Vol.40 (1), p.30-35</ispartof><rights>Copyright Oxford Publishing Limited(England) Jan 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-b840697cb20f51db41e34c02a467916d30b74a95c4b2c70e0a1425bc501bc2483</citedby><cites>FETCH-LOGICAL-c492t-b840697cb20f51db41e34c02a467916d30b74a95c4b2c70e0a1425bc501bc2483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934,31008,31009</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21106558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chan, Wai Chi</creatorcontrib><creatorcontrib>Lam, Linda C W</creatorcontrib><creatorcontrib>Tam, Cindy W C</creatorcontrib><creatorcontrib>Lui, Victor W C</creatorcontrib><creatorcontrib>Leung, Grace T Y</creatorcontrib><creatorcontrib>Lee, Allen T C</creatorcontrib><creatorcontrib>Chan, Sandra S M</creatorcontrib><creatorcontrib>Fung, Ada W T</creatorcontrib><creatorcontrib>Chiu, Helen F K</creatorcontrib><creatorcontrib>Chan, Wai Man</creatorcontrib><title>Neuropsychiatric symptoms are associated with increased risks of progression to dementia: a 2-year prospective study of 321 Chinese older persons with mild cognitive impairment</title><title>Age and ageing</title><addtitle>Age Ageing</addtitle><description>studies have suggested that neuropsychiatric (NP) symptoms influence the development of dementia among older adults. But, the results are inconsistent and there is limited information about NP symptoms in population-based samples.
to explore the association between NP symptoms and risk of cognitive decline in Chinese older persons residing in the community.
prospective study.
community sample.
a total of 321 community-dwelling Chinese older persons aged 60 or over with mild cognitive impairment participated in the study.
at baseline, each subject was assessed with Clinical Dementia Rating (CDR), Mini-Mental State Examination, list learning and delayed recall, and Category Verbal Fluency Test. Severity of NP symptoms was evaluated with Neuropsychiatric Inventory (NPI). Global cognitive status at the end of 2-year study period was determined by CDR.
at baseline, 40.5% of participants exhibited one or more NP symptoms (NPI total score ≥ 1). Night-time behaviours (22.1%), depression (16.8%), apathy (14.0%) and anxiety (12.8%) were the most common NP symptoms. At the end of 2-year follow-up, 27.5% of participants with depression at baseline developed dementia, compared with 14.8% of those without depression (χ² = 4.90, P= 0.03). Aberrant motor behaviour was also significantly associated with deterioration in cognition (χ² = 5.84, P= 0.02), although it was an infrequent occurrence. On logistic regression analysis, only depression at baseline was shown to be a risk factor for progression to dementia (OR= 2.40, 95% CI 1.05-5.46, P= 0.04).
depression in non-demented older persons may represent an independent dimension reflecting early neuronal degeneration. Further studies should be conducted to assess whether effective management of NP symptoms exerts beneficial effects on cognitive function.</description><subject>Aged</subject><subject>Aged patients</subject><subject>Aged, 80 and over</subject><subject>Anxiety-Depression</subject><subject>Asian people</subject><subject>Care and treatment</subject><subject>China</subject><subject>Cognition Disorders - complications</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - ethnology</subject><subject>Cognitive ability</subject><subject>Cognitive impairment</subject><subject>Dementia</subject><subject>Dementia - epidemiology</subject><subject>Depression - complications</subject><subject>Depression - diagnosis</subject><subject>Depression - ethnology</subject><subject>Development and progression</subject><subject>Disease Progression</subject><subject>Elderly patients</subject><subject>Elderly people</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Mental depression</subject><subject>Nerve Degeneration - complications</subject><subject>Nerve Degeneration - diagnosis</subject><subject>Nerve Degeneration - ethnology</subject><subject>Neurodegeneration</subject><subject>Neuropsychiatric symptoms</subject><subject>Neuropsychological Tests</subject><subject>Older people</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Psychiatry</subject><subject>Psychological aspects</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Symptoms</subject><issn>0002-0729</issn><issn>1468-2834</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFksFu1DAQhiMEotvCkSuyuHAKtR07sblVKyhIFb3A2XKc2axLEqceB8hb8Yh42QISl5VGGo38zXg0_18ULxh9w6iuLm0Pfuov7e6eSfao2DBRq5KrSjwuNpRSXtKG67PiHPEul5nhT4szzhitpVSb4ucnWGKYcXV7b1P0juA6zimMSGwEYhGDyw_Qke8-7YmfXASLuYwevyIJOzLH0EdA9GEiKZAORpiSt2-JJbxcwcYDgTO45L8BwbR066Gt4oxs934CBBKGDjIGEcOEx49GP3TEhX7yv9v8OFsfD5OfFU92dkB4_pAvii_v333efihvbq8_bq9uSic0T2WrBK1141pOd5J1rWBQCUe5FXWjWd1VtG2E1dKJlruGArVMcNk6SVnruFDVRfH6ODdvf78AJjN6dDAMdoKwoNFSSK205qdJ2jBZ5ThJqiyJ1rXSp8msoBaskZl89R95F5Y45dMYJZRSkuoDVB6h3g5gsohhSvAjuTAM0IPJh9vemisueaUkF9U_3mXpMMLOzNGPNq6GUXOwnTnazhxtl_mXD0ss7QjdX_qPz6pfrqLWDQ</recordid><startdate>201101</startdate><enddate>201101</enddate><creator>Chan, Wai Chi</creator><creator>Lam, Linda C W</creator><creator>Tam, Cindy W C</creator><creator>Lui, Victor W C</creator><creator>Leung, Grace T Y</creator><creator>Lee, Allen T C</creator><creator>Chan, Sandra S M</creator><creator>Fung, Ada W T</creator><creator>Chiu, Helen F K</creator><creator>Chan, Wai Man</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>201101</creationdate><title>Neuropsychiatric symptoms are associated with increased risks of progression to dementia: a 2-year prospective study of 321 Chinese older persons with mild cognitive impairment</title><author>Chan, Wai Chi ; Lam, Linda C W ; Tam, Cindy W C ; Lui, Victor W C ; Leung, Grace T Y ; Lee, Allen T C ; Chan, Sandra S M ; Fung, Ada W T ; Chiu, Helen F K ; Chan, Wai Man</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-b840697cb20f51db41e34c02a467916d30b74a95c4b2c70e0a1425bc501bc2483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Aged patients</topic><topic>Aged, 80 and over</topic><topic>Anxiety-Depression</topic><topic>Asian people</topic><topic>Care and treatment</topic><topic>China</topic><topic>Cognition Disorders - complications</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - ethnology</topic><topic>Cognitive ability</topic><topic>Cognitive impairment</topic><topic>Dementia</topic><topic>Dementia - epidemiology</topic><topic>Depression - complications</topic><topic>Depression - diagnosis</topic><topic>Depression - ethnology</topic><topic>Development and progression</topic><topic>Disease Progression</topic><topic>Elderly patients</topic><topic>Elderly people</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Mental depression</topic><topic>Nerve Degeneration - complications</topic><topic>Nerve Degeneration - diagnosis</topic><topic>Nerve Degeneration - ethnology</topic><topic>Neurodegeneration</topic><topic>Neuropsychiatric symptoms</topic><topic>Neuropsychological Tests</topic><topic>Older people</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Psychiatry</topic><topic>Psychological aspects</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Symptoms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan, Wai Chi</creatorcontrib><creatorcontrib>Lam, Linda C W</creatorcontrib><creatorcontrib>Tam, Cindy W C</creatorcontrib><creatorcontrib>Lui, Victor W C</creatorcontrib><creatorcontrib>Leung, Grace T Y</creatorcontrib><creatorcontrib>Lee, Allen T C</creatorcontrib><creatorcontrib>Chan, Sandra S M</creatorcontrib><creatorcontrib>Fung, Ada W T</creatorcontrib><creatorcontrib>Chiu, Helen F K</creatorcontrib><creatorcontrib>Chan, Wai Man</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Age and ageing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chan, Wai Chi</au><au>Lam, Linda C W</au><au>Tam, Cindy W C</au><au>Lui, Victor W C</au><au>Leung, Grace T Y</au><au>Lee, Allen T C</au><au>Chan, Sandra S M</au><au>Fung, Ada W T</au><au>Chiu, Helen F K</au><au>Chan, Wai Man</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuropsychiatric symptoms are associated with increased risks of progression to dementia: a 2-year prospective study of 321 Chinese older persons with mild cognitive impairment</atitle><jtitle>Age and ageing</jtitle><addtitle>Age Ageing</addtitle><date>2011-01</date><risdate>2011</risdate><volume>40</volume><issue>1</issue><spage>30</spage><epage>35</epage><pages>30-35</pages><issn>0002-0729</issn><eissn>1468-2834</eissn><coden>AANGAH</coden><abstract>studies have suggested that neuropsychiatric (NP) symptoms influence the development of dementia among older adults. But, the results are inconsistent and there is limited information about NP symptoms in population-based samples.
to explore the association between NP symptoms and risk of cognitive decline in Chinese older persons residing in the community.
prospective study.
community sample.
a total of 321 community-dwelling Chinese older persons aged 60 or over with mild cognitive impairment participated in the study.
at baseline, each subject was assessed with Clinical Dementia Rating (CDR), Mini-Mental State Examination, list learning and delayed recall, and Category Verbal Fluency Test. Severity of NP symptoms was evaluated with Neuropsychiatric Inventory (NPI). Global cognitive status at the end of 2-year study period was determined by CDR.
at baseline, 40.5% of participants exhibited one or more NP symptoms (NPI total score ≥ 1). Night-time behaviours (22.1%), depression (16.8%), apathy (14.0%) and anxiety (12.8%) were the most common NP symptoms. At the end of 2-year follow-up, 27.5% of participants with depression at baseline developed dementia, compared with 14.8% of those without depression (χ² = 4.90, P= 0.03). Aberrant motor behaviour was also significantly associated with deterioration in cognition (χ² = 5.84, P= 0.02), although it was an infrequent occurrence. On logistic regression analysis, only depression at baseline was shown to be a risk factor for progression to dementia (OR= 2.40, 95% CI 1.05-5.46, P= 0.04).
depression in non-demented older persons may represent an independent dimension reflecting early neuronal degeneration. Further studies should be conducted to assess whether effective management of NP symptoms exerts beneficial effects on cognitive function.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>21106558</pmid><doi>10.1093/ageing/afq151</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Aged Aged patients Aged, 80 and over Anxiety-Depression Asian people Care and treatment China Cognition Disorders - complications Cognition Disorders - diagnosis Cognition Disorders - ethnology Cognitive ability Cognitive impairment Dementia Dementia - epidemiology Depression - complications Depression - diagnosis Depression - ethnology Development and progression Disease Progression Elderly patients Elderly people Female Follow-Up Studies Humans Longitudinal Studies Male Mental depression Nerve Degeneration - complications Nerve Degeneration - diagnosis Nerve Degeneration - ethnology Neurodegeneration Neuropsychiatric symptoms Neuropsychological Tests Older people Prognosis Prospective Studies Psychiatry Psychological aspects Regression Analysis Risk Factors Symptoms |
| title | Neuropsychiatric symptoms are associated with increased risks of progression to dementia: a 2-year prospective study of 321 Chinese older persons with mild cognitive impairment |
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