Mechanisms of Centrosome Separation and Bipolar Spindle Assembly

Accurate segregation of chromosomes during cell division is accomplished through the assembly of a bipolar microtubule-based structure called the mitotic spindle. Work over the past two decades has identified a core regulator of spindle bipolarity, the microtubule motor protein kinesin-5. However, a...

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Veröffentlicht in:	Developmental cell 2010-12, Vol.19 (6), p.797-806
Hauptverfasser:	Tanenbaum, Marvin E., Medema, René H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomechanical Phenomena Cell differentiation, maturation, development, hematopoiesis Cell Division - physiology Cell physiology Centrosome - physiology Fundamental and applied biological sciences. Psychology Humans Kinesin - physiology Kinetochores - physiology Microtubules - physiology Models, Biological Molecular and cellular biology Molecular Motor Proteins - physiology Nuclear Envelope - physiology Prophase - physiology Spindle Apparatus - physiology
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