Mechanisms of Centrosome Separation and Bipolar Spindle Assembly
Accurate segregation of chromosomes during cell division is accomplished through the assembly of a bipolar microtubule-based structure called the mitotic spindle. Work over the past two decades has identified a core regulator of spindle bipolarity, the microtubule motor protein kinesin-5. However, a...
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| Veröffentlicht in: | Developmental cell 2010-12, Vol.19 (6), p.797-806 |
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| container_title | Developmental cell |
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| creator | Tanenbaum, Marvin E. Medema, René H. |
| description | Accurate segregation of chromosomes during cell division is accomplished through the assembly of a bipolar microtubule-based structure called the mitotic spindle. Work over the past two decades has identified a core regulator of spindle bipolarity, the microtubule motor protein kinesin-5. However, an increasing body of evidence has emerged demonstrating that kinesin-5-independent mechanisms driving bipolar spindle assembly exist as well. Here, we discuss different pathways that promote initial centrosome separation and bipolar spindle assembly. |
| doi_str_mv | 10.1016/j.devcel.2010.11.011 |
| format | Article |
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Work over the past two decades has identified a core regulator of spindle bipolarity, the microtubule motor protein kinesin-5. However, an increasing body of evidence has emerged demonstrating that kinesin-5-independent mechanisms driving bipolar spindle assembly exist as well. Here, we discuss different pathways that promote initial centrosome separation and bipolar spindle assembly.</description><identifier>ISSN: 1534-5807</identifier><identifier>EISSN: 1878-1551</identifier><identifier>DOI: 10.1016/j.devcel.2010.11.011</identifier><identifier>PMID: 21145497</identifier><language>eng</language><publisher>Cambridge, MA: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Biomechanical Phenomena ; Cell differentiation, maturation, development, hematopoiesis ; Cell Division - physiology ; Cell physiology ; Centrosome - physiology ; Fundamental and applied biological sciences. 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| ispartof | Developmental cell, 2010-12, Vol.19 (6), p.797-806 |
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| language | eng |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Biological and medical sciences Biomechanical Phenomena Cell differentiation, maturation, development, hematopoiesis Cell Division - physiology Cell physiology Centrosome - physiology Fundamental and applied biological sciences. Psychology Humans Kinesin - physiology Kinetochores - physiology Microtubules - physiology Models, Biological Molecular and cellular biology Molecular Motor Proteins - physiology Nuclear Envelope - physiology Prophase - physiology Spindle Apparatus - physiology |
| title | Mechanisms of Centrosome Separation and Bipolar Spindle Assembly |
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