Decrease in the osteocyte lacunar density accompanied by hypermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone
Summary Aging decreases the human femur’s fatigue resistance, impact energy absorption, and the ability to withstand load. Changes in the osteocyte distribution and in their elemental composition might be involved in age‐related bone impairment. To address this question, we carried out a histomorpho...
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| Veröffentlicht in: | Aging cell 2010-12, Vol.9 (6), p.1065-1075 |
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| creator | Busse, Björn Djonic, Danijela Milovanovic, Petar Hahn, Michael Püschel, Klaus Ritchie, Robert O. Djuric, Marija Amling, Michael |
| description | Summary
Aging decreases the human femur’s fatigue resistance, impact energy absorption, and the ability to withstand load. Changes in the osteocyte distribution and in their elemental composition might be involved in age‐related bone impairment. To address this question, we carried out a histomorphometric assessment of the osteocyte lacunar distribution in the periosteal and endosteal human femoral cortexes of 16 female and 16 male donors with regard to age‐ and sex‐related bone remodeling. Measurements of the bone mineral density distribution by quantitative backscattered electron imaging and energy dispersive X‐ray analysis were taken to evaluate the osteocyte lacunar mineral composition and characteristics. Age‐dependent decreases in the total osteocyte lacunar number were measured in all of the cases. This change signifies a risk for the bone’s safety. Cortical subdivision into periosteal and endosteal regions of interest emphasized that, in both sexes, primarily the endosteal cortex is affected by age‐dependent reduction in number of osteocyte lacunae, whereas the periosteal compartment showed a less pronounced osteocyte lacunar deficiency. In aged bone, osteocyte lacunae showed an increased amount of hypermineralized calcium phosphate occlusions in comparison with younger cases. With respect to Frost’s early delineation of micropetrosis, our microanalyses revealed that the osteocyte lacunae are subject to hypermineralization. Intralacunar hypermineralization accompanied by a decrease in total osteocyte lacunar density may contribute to failure or delayed bone repair in aging bone. A decreased osteocyte lacunar density may cause deteriorations in the canalicular fluid flow and reduce the detection of microdamage, which counteracts the bone’s structural integrity, while hypermineralized osteocyte lacunae may increase bone brittleness and render the bone fragile. |
| doi_str_mv | 10.1111/j.1474-9726.2010.00633.x |
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Aging decreases the human femur’s fatigue resistance, impact energy absorption, and the ability to withstand load. Changes in the osteocyte distribution and in their elemental composition might be involved in age‐related bone impairment. To address this question, we carried out a histomorphometric assessment of the osteocyte lacunar distribution in the periosteal and endosteal human femoral cortexes of 16 female and 16 male donors with regard to age‐ and sex‐related bone remodeling. Measurements of the bone mineral density distribution by quantitative backscattered electron imaging and energy dispersive X‐ray analysis were taken to evaluate the osteocyte lacunar mineral composition and characteristics. Age‐dependent decreases in the total osteocyte lacunar number were measured in all of the cases. This change signifies a risk for the bone’s safety. Cortical subdivision into periosteal and endosteal regions of interest emphasized that, in both sexes, primarily the endosteal cortex is affected by age‐dependent reduction in number of osteocyte lacunae, whereas the periosteal compartment showed a less pronounced osteocyte lacunar deficiency. In aged bone, osteocyte lacunae showed an increased amount of hypermineralized calcium phosphate occlusions in comparison with younger cases. With respect to Frost’s early delineation of micropetrosis, our microanalyses revealed that the osteocyte lacunae are subject to hypermineralization. Intralacunar hypermineralization accompanied by a decrease in total osteocyte lacunar density may contribute to failure or delayed bone repair in aging bone. A decreased osteocyte lacunar density may cause deteriorations in the canalicular fluid flow and reduce the detection of microdamage, which counteracts the bone’s structural integrity, while hypermineralized osteocyte lacunae may increase bone brittleness and render the bone fragile.</description><identifier>ISSN: 1474-9718</identifier><identifier>EISSN: 1474-9726</identifier><identifier>DOI: 10.1111/j.1474-9726.2010.00633.x</identifier><identifier>PMID: 20874757</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Age ; Aged ; Aged, 80 and over ; Aging ; Aging - physiology ; apoptosis ; Bone and Bones - diagnostic imaging ; Bone composition ; Bone Density ; Bone healing ; bone histomorphometry ; Bone mineral density ; Bone Remodeling - physiology ; Bone remodelling ; Calcium phosphate ; electron microscopy ; Electron Probe Microanalysis ; Energy ; Fatigue ; Female ; Femur ; Femur - cytology ; Femur - diagnostic imaging ; Femur - physiology ; Fluid flow ; Fractures ; Frost ; Humans ; Ionizing radiation ; Male ; microanalysis ; Middle Aged ; Neuroimaging ; Occlusion ; osteocyte death ; Osteocytes ; Osteocytes - cytology ; Osteocytes - diagnostic imaging ; Radiography ; Sex</subject><ispartof>Aging cell, 2010-12, Vol.9 (6), p.1065-1075</ispartof><rights>2010 The Authors. Aging Cell © 2010 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland</rights><rights>2010 The Authors. Aging Cell © 2010 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5163-7705060a14281118cf7c65fd670f51b4292b0b7cbb486fd81bb79be95283cf583</citedby><cites>FETCH-LOGICAL-c5163-7705060a14281118cf7c65fd670f51b4292b0b7cbb486fd81bb79be95283cf583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1474-9726.2010.00633.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1474-9726.2010.00633.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,11562,27924,27925,45574,45575,46052,46476</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1474-9726.2010.00633.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20874757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Busse, Björn</creatorcontrib><creatorcontrib>Djonic, Danijela</creatorcontrib><creatorcontrib>Milovanovic, Petar</creatorcontrib><creatorcontrib>Hahn, Michael</creatorcontrib><creatorcontrib>Püschel, Klaus</creatorcontrib><creatorcontrib>Ritchie, Robert O.</creatorcontrib><creatorcontrib>Djuric, Marija</creatorcontrib><creatorcontrib>Amling, Michael</creatorcontrib><title>Decrease in the osteocyte lacunar density accompanied by hypermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone</title><title>Aging cell</title><addtitle>Aging Cell</addtitle><description>Summary
Aging decreases the human femur’s fatigue resistance, impact energy absorption, and the ability to withstand load. Changes in the osteocyte distribution and in their elemental composition might be involved in age‐related bone impairment. To address this question, we carried out a histomorphometric assessment of the osteocyte lacunar distribution in the periosteal and endosteal human femoral cortexes of 16 female and 16 male donors with regard to age‐ and sex‐related bone remodeling. Measurements of the bone mineral density distribution by quantitative backscattered electron imaging and energy dispersive X‐ray analysis were taken to evaluate the osteocyte lacunar mineral composition and characteristics. Age‐dependent decreases in the total osteocyte lacunar number were measured in all of the cases. This change signifies a risk for the bone’s safety. Cortical subdivision into periosteal and endosteal regions of interest emphasized that, in both sexes, primarily the endosteal cortex is affected by age‐dependent reduction in number of osteocyte lacunae, whereas the periosteal compartment showed a less pronounced osteocyte lacunar deficiency. In aged bone, osteocyte lacunae showed an increased amount of hypermineralized calcium phosphate occlusions in comparison with younger cases. With respect to Frost’s early delineation of micropetrosis, our microanalyses revealed that the osteocyte lacunae are subject to hypermineralization. Intralacunar hypermineralization accompanied by a decrease in total osteocyte lacunar density may contribute to failure or delayed bone repair in aging bone. A decreased osteocyte lacunar density may cause deteriorations in the canalicular fluid flow and reduce the detection of microdamage, which counteracts the bone’s structural integrity, while hypermineralized osteocyte lacunae may increase bone brittleness and render the bone fragile.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>apoptosis</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone composition</subject><subject>Bone Density</subject><subject>Bone healing</subject><subject>bone histomorphometry</subject><subject>Bone mineral density</subject><subject>Bone Remodeling - physiology</subject><subject>Bone remodelling</subject><subject>Calcium phosphate</subject><subject>electron microscopy</subject><subject>Electron Probe Microanalysis</subject><subject>Energy</subject><subject>Fatigue</subject><subject>Female</subject><subject>Femur</subject><subject>Femur - cytology</subject><subject>Femur - diagnostic imaging</subject><subject>Femur - physiology</subject><subject>Fluid flow</subject><subject>Fractures</subject><subject>Frost</subject><subject>Humans</subject><subject>Ionizing radiation</subject><subject>Male</subject><subject>microanalysis</subject><subject>Middle Aged</subject><subject>Neuroimaging</subject><subject>Occlusion</subject><subject>osteocyte death</subject><subject>Osteocytes</subject><subject>Osteocytes - cytology</subject><subject>Osteocytes - diagnostic imaging</subject><subject>Radiography</subject><subject>Sex</subject><issn>1474-9718</issn><issn>1474-9726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u3CAUha2qVZMmfYWKXVczAWMMXnQRTfNTaaRu2jUCfMkwwjAFu437IH3e4kwy25YNl3u_c67EqSpE8JqUc7Vfk4Y3q47X7brGpYtxS-n68VV1fhq8PtVEnFXvct5jTHiH6dvqrMaCN5zx8-rPZzAJVAbkAhp3gGIeIZp5BOSVmYJKqIeQ3TgjZUwcDio46JGe0W4-QBpcgKS8-116L3w0xk_ZxYAS_ATlM7LK-SkBUqEvbl7NKNoyHGJ5uPCwrFYPxWE3DSogHQNcVm9sUcL75_ui-n57821zv9p-vfuyud6uDCMtXXGOGW6xIk0tyr8IY7lpme1bji0juqm7WmPNjdaNaG0viNa809CxWlBjmaAX1cej7yHFHxPkUQ4uG_BeBYhTlh1rWMcxp_8kBWGFJbQtpDiSJsWcE1h5SG5QaZYEyyU-uZdLMnJJSS7xyaf45GORfnheMukB-pPwJa8CfDoCv5yH-b-N5fXmZlsq-hdMYKtP</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>Busse, Björn</creator><creator>Djonic, Danijela</creator><creator>Milovanovic, Petar</creator><creator>Hahn, Michael</creator><creator>Püschel, Klaus</creator><creator>Ritchie, Robert O.</creator><creator>Djuric, Marija</creator><creator>Amling, Michael</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>201012</creationdate><title>Decrease in the osteocyte lacunar density accompanied by hypermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone</title><author>Busse, Björn ; Djonic, Danijela ; Milovanovic, Petar ; Hahn, Michael ; Püschel, Klaus ; Ritchie, Robert O. ; Djuric, Marija ; Amling, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5163-7705060a14281118cf7c65fd670f51b4292b0b7cbb486fd81bb79be95283cf583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>apoptosis</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Bone composition</topic><topic>Bone Density</topic><topic>Bone healing</topic><topic>bone histomorphometry</topic><topic>Bone mineral density</topic><topic>Bone Remodeling - physiology</topic><topic>Bone remodelling</topic><topic>Calcium phosphate</topic><topic>electron microscopy</topic><topic>Electron Probe Microanalysis</topic><topic>Energy</topic><topic>Fatigue</topic><topic>Female</topic><topic>Femur</topic><topic>Femur - cytology</topic><topic>Femur - diagnostic imaging</topic><topic>Femur - physiology</topic><topic>Fluid flow</topic><topic>Fractures</topic><topic>Frost</topic><topic>Humans</topic><topic>Ionizing radiation</topic><topic>Male</topic><topic>microanalysis</topic><topic>Middle Aged</topic><topic>Neuroimaging</topic><topic>Occlusion</topic><topic>osteocyte death</topic><topic>Osteocytes</topic><topic>Osteocytes - cytology</topic><topic>Osteocytes - diagnostic imaging</topic><topic>Radiography</topic><topic>Sex</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Busse, Björn</creatorcontrib><creatorcontrib>Djonic, Danijela</creatorcontrib><creatorcontrib>Milovanovic, Petar</creatorcontrib><creatorcontrib>Hahn, Michael</creatorcontrib><creatorcontrib>Püschel, Klaus</creatorcontrib><creatorcontrib>Ritchie, Robert O.</creatorcontrib><creatorcontrib>Djuric, Marija</creatorcontrib><creatorcontrib>Amling, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Aging cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Busse, Björn</au><au>Djonic, Danijela</au><au>Milovanovic, Petar</au><au>Hahn, Michael</au><au>Püschel, Klaus</au><au>Ritchie, Robert O.</au><au>Djuric, Marija</au><au>Amling, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decrease in the osteocyte lacunar density accompanied by hypermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone</atitle><jtitle>Aging cell</jtitle><addtitle>Aging Cell</addtitle><date>2010-12</date><risdate>2010</risdate><volume>9</volume><issue>6</issue><spage>1065</spage><epage>1075</epage><pages>1065-1075</pages><issn>1474-9718</issn><eissn>1474-9726</eissn><abstract>Summary
Aging decreases the human femur’s fatigue resistance, impact energy absorption, and the ability to withstand load. Changes in the osteocyte distribution and in their elemental composition might be involved in age‐related bone impairment. To address this question, we carried out a histomorphometric assessment of the osteocyte lacunar distribution in the periosteal and endosteal human femoral cortexes of 16 female and 16 male donors with regard to age‐ and sex‐related bone remodeling. Measurements of the bone mineral density distribution by quantitative backscattered electron imaging and energy dispersive X‐ray analysis were taken to evaluate the osteocyte lacunar mineral composition and characteristics. Age‐dependent decreases in the total osteocyte lacunar number were measured in all of the cases. This change signifies a risk for the bone’s safety. Cortical subdivision into periosteal and endosteal regions of interest emphasized that, in both sexes, primarily the endosteal cortex is affected by age‐dependent reduction in number of osteocyte lacunae, whereas the periosteal compartment showed a less pronounced osteocyte lacunar deficiency. In aged bone, osteocyte lacunae showed an increased amount of hypermineralized calcium phosphate occlusions in comparison with younger cases. With respect to Frost’s early delineation of micropetrosis, our microanalyses revealed that the osteocyte lacunae are subject to hypermineralization. Intralacunar hypermineralization accompanied by a decrease in total osteocyte lacunar density may contribute to failure or delayed bone repair in aging bone. A decreased osteocyte lacunar density may cause deteriorations in the canalicular fluid flow and reduce the detection of microdamage, which counteracts the bone’s structural integrity, while hypermineralized osteocyte lacunae may increase bone brittleness and render the bone fragile.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20874757</pmid><doi>10.1111/j.1474-9726.2010.00633.x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Aged Aged, 80 and over Aging Aging - physiology apoptosis Bone and Bones - diagnostic imaging Bone composition Bone Density Bone healing bone histomorphometry Bone mineral density Bone Remodeling - physiology Bone remodelling Calcium phosphate electron microscopy Electron Probe Microanalysis Energy Fatigue Female Femur Femur - cytology Femur - diagnostic imaging Femur - physiology Fluid flow Fractures Frost Humans Ionizing radiation Male microanalysis Middle Aged Neuroimaging Occlusion osteocyte death Osteocytes Osteocytes - cytology Osteocytes - diagnostic imaging Radiography Sex |
| title | Decrease in the osteocyte lacunar density accompanied by hypermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone |
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