Molecular effects of interleukin-1β on dorsal root ganglion neurons: Prevention of ligand-induced internalization of the bradykinin 2 receptor and downregulation of G protein-coupled receptor kinase 2

In dorsal root ganglion sections numerous small-to medium-sized neurons were found to exhibit extensive colocalization of the bradykinin receptor 2, the interleukin-1 receptor 1 and G protein-coupled receptor kinase 2. Application of bradykinin to cultured DRG neurons caused substantial internalizat...

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Veröffentlicht in:	Molecular and cellular neuroscience 2011-01, Vol.46 (1), p.262-271
Hauptverfasser:	von Banchet, Gisela Segond, Fischer, Nadja, Uhlig, Benjamin, Hensellek, Susanne, Eitner, Annett, Schaible, Hans-Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bradykinin - metabolism Bradykinin - pharmacology Bradykinin receptor 2 Cell Membrane - metabolism Dorsal root ganglion G protein-coupled receptor kinase 2 G-Protein-Coupled Receptor Kinase 2 - genetics G-Protein-Coupled Receptor Kinase 2 - metabolism Ganglia, Spinal - cytology Ganglia, Spinal - drug effects Interleukin-1beta - pharmacology Interleukin-1β Male Neurons - cytology Neurons - drug effects Rats Rats, Wistar Receptor internalization Receptor, Bradykinin B2 - genetics Receptor, Bradykinin B2 - metabolism Receptors, Interleukin-1 Type I - genetics Receptors, Interleukin-1 Type I - metabolism
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