Peroxynitrite-scavenging constituents from the brown algaSargassum thunbergii
Peroxynitrite formationin vivo is implicated in numerous human diseases and there is considerable interest in the use of antioxidants and natural products for their treatment. The three components (1-3) isolated fromSargassum thunbergii as well as the organic solventsoluble fractions and the aqueous...
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| Veröffentlicht in: | Biotechnology and bioprocess engineering 2004-06, Vol.9 (3), p.212-216 |
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| container_title | Biotechnology and bioprocess engineering |
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| creator | Seo, Youngwan Lee, Hee-Jung Park, Ki Eui Kim, You Ah Ahn, Jong Woong Yoo, Jong Su Lee, Burm-Jong |
| description | Peroxynitrite formationin vivo is implicated in numerous human diseases and there is considerable interest in the use of antioxidants and natural products for their treatment. The three components (1-3) isolated fromSargassum thunbergii as well as the organic solventsoluble fractions and the aqueous layer ofS. thunbergii were evaluated for their potential to scavenge authentic ONOO and ONOO derived from 3-morpholinosydnonimine (SIN-1). The antioxidant activity of the individual fractions was in the order of 85% aquaous (aq.) MeOH>n-BuOH>n-hexane> H^sub 2^O. The three known compounds sargahydroquinoic acid (1), sargaquinoic acid (2) and sargachromenol (3) showed peroxynitrite-scavenging activities comparable to those of L-ascorbic acid and penicillamine. These results showed a possible antioxidant activity in major constituents ofS. thunbergii.[PUBLICATION ABSTRACT] |
| doi_str_mv | 10.1007/BF02942295 |
| format | Article |
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The three components (1-3) isolated fromSargassum thunbergii as well as the organic solventsoluble fractions and the aqueous layer ofS. thunbergii were evaluated for their potential to scavenge authentic ONOO and ONOO derived from 3-morpholinosydnonimine (SIN-1). The antioxidant activity of the individual fractions was in the order of 85% aquaous (aq.) MeOH>n-BuOH>n-hexane> H^sub 2^O. The three known compounds sargahydroquinoic acid (1), sargaquinoic acid (2) and sargachromenol (3) showed peroxynitrite-scavenging activities comparable to those of L-ascorbic acid and penicillamine. 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| ispartof | Biotechnology and bioprocess engineering, 2004-06, Vol.9 (3), p.212-216 |
| issn | 1226-8372 1976-3816 |
| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Antioxidants Ascorbic acid Constituents Hexanes n-Hexane Natural products Peroxynitrite Scavenging Vitamin C |
| title | Peroxynitrite-scavenging constituents from the brown algaSargassum thunbergii |
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