Interactions between Verapamil and Digoxin in Langendorff‐Perfused Rat Hearts: The Role of Inhibition of P‐glycoprotein in the Heart

: P‐glycoprotein (P‐gp) is expressed in tumour cells as well as normal tissues including heart. Modulation of P‐gp transport in vivo may lead to increased drug penetrance to tissues with resulting increases in toxicity. We aimed to investigate the effects of P‐gp on the isolated heart by digoxin in...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2010-11, Vol.107 (5), p.847-852
Hauptverfasser:	Aylin Arici, Mualla, Kilinc, Emrah, Demir, Omer, Ates, Mehmet, Yesilyurt, Alaattin, Gelal, Ayse
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors Biological and medical sciences Chromatography, High Pressure Liquid digoxin Digoxin - pharmacokinetics Digoxin - pharmacology Drug Interactions Drugs Female Heart Heart Rate - drug effects Heart Ventricles - drug effects Heart Ventricles - metabolism In Vitro Techniques Medical sciences P-Glycoprotein Perfusion Pharmacology. Drug treatments Pressure Rats Rats, Wistar Toxicity Ventricle Ventricular Function, Left - drug effects Verapamil Verapamil - pharmacokinetics Verapamil - pharmacology
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