Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers
A series of low molecular weight biaryl substituted oxazoles, imidazoles, and thiazoles were identified as Na v1.7 blockers. These state dependent sodium channel blockers were synthesized and evaluated for treatment of neuropathic pain. Voltage-gated sodium channels have been shown to play a critica...
Gespeichert in:
| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2010-09, Vol.20 (18), p.5536-5540 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 5540 |
|---|---|
| container_issue | 18 |
| container_start_page | 5536 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 20 |
| creator | Tyagarajan, Sriram Chakravarty, Prasun K. Zhou, Bishan Fisher, Michael H. Wyvratt, Mathew J. Lyons, Kathy Klatt, Tracy Li, Xiaohua Kumar, Sanjeev Williams, Brande Felix, John Priest, Birgit T. Brochu, Richard M. Warren, Vivien Smith, McHardy Garcia, Maria Kaczorowski, Gregory J. Martin, William J. Abbadie, Catherine McGowan, Erin Jochnowitz, Nina Parsons, William H. |
| description | A series of low molecular weight biaryl substituted oxazoles, imidazoles, and thiazoles were identified as Na
v1.7 blockers. These state dependent sodium channel blockers were synthesized and evaluated for treatment of neuropathic pain.
Voltage-gated sodium channels have been shown to play a critical role in neuropathic pain. With a goal to develop potent peripherally active sodium channel blockers, a series of low molecular weight biaryl substituted imidazoles, oxazoles, and thiazole carboxamides were identified with good in vitro and in vivo potency. |
| doi_str_mv | 10.1016/j.bmcl.2010.07.064 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_954592005</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0960894X10010206</els_id><sourcerecordid>954592005</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-a704446ec8a3aa18fed1ceabf5bf633c7e32ffef8c00427ef26f4ecc4f8cd8d63</originalsourceid><addsrcrecordid>eNqFkEtv1DAQgC1ERZfCH-CAckFcyDJ-JE4kLlXFS6qEECBxs5zxWPXiJMVOUMuvx6vdwq2c5qFvHvoYe8Zhy4G3r3fbYcS4FVAaoLfQqgdsw1Wraqmgecg20LdQd736fsoe57wD4AqUesROBWjom0Zs2Ocv65CXsKwLuWoINt3Gar6xv-dI-VUVxuDucju5arkKh7KyucqzC-tY4ZWdJorVEGf8QSk_YSfexkxPj_GMfXv39uvFh_ry0_uPF-eXNSqul9rq8opqCTsrreWdJ8eR7OCbwbdSoiYpvCffIYASmrxovSJEVTquc608Yy8Pe6_T_HOlvJgxZKQY7UTzmk3fqKYXAM1_Sd2oorDXspDiQGKac07kzXUKY5FiOJi9c7Mze-dm79yANsV5GXp-XL8OI7m_I3eSC_DiCNiMNvpkJwz5HyeF6iTsr785cFS0_QqUTMZAE5ILiXAxbg73_fEHo3ehOg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>754010973</pqid></control><display><type>article</type><title>Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Tyagarajan, Sriram ; Chakravarty, Prasun K. ; Zhou, Bishan ; Fisher, Michael H. ; Wyvratt, Mathew J. ; Lyons, Kathy ; Klatt, Tracy ; Li, Xiaohua ; Kumar, Sanjeev ; Williams, Brande ; Felix, John ; Priest, Birgit T. ; Brochu, Richard M. ; Warren, Vivien ; Smith, McHardy ; Garcia, Maria ; Kaczorowski, Gregory J. ; Martin, William J. ; Abbadie, Catherine ; McGowan, Erin ; Jochnowitz, Nina ; Parsons, William H.</creator><creatorcontrib>Tyagarajan, Sriram ; Chakravarty, Prasun K. ; Zhou, Bishan ; Fisher, Michael H. ; Wyvratt, Mathew J. ; Lyons, Kathy ; Klatt, Tracy ; Li, Xiaohua ; Kumar, Sanjeev ; Williams, Brande ; Felix, John ; Priest, Birgit T. ; Brochu, Richard M. ; Warren, Vivien ; Smith, McHardy ; Garcia, Maria ; Kaczorowski, Gregory J. ; Martin, William J. ; Abbadie, Catherine ; McGowan, Erin ; Jochnowitz, Nina ; Parsons, William H.</creatorcontrib><description>A series of low molecular weight biaryl substituted oxazoles, imidazoles, and thiazoles were identified as Na
v1.7 blockers. These state dependent sodium channel blockers were synthesized and evaluated for treatment of neuropathic pain.
Voltage-gated sodium channels have been shown to play a critical role in neuropathic pain. With a goal to develop potent peripherally active sodium channel blockers, a series of low molecular weight biaryl substituted imidazoles, oxazoles, and thiazole carboxamides were identified with good in vitro and in vivo potency.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2010.07.064</identifier><identifier>PMID: 20709552</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Analgesics ; Animals ; Biaryl imidazoles ; Biaryl oxazoles ; Biaryl thiazoles ; Biological and medical sciences ; Dogs ; Humans ; Imidazoles - chemistry ; Imidazoles - metabolism ; Imidazoles - pharmacology ; Imidazoles - therapeutic use ; Medical sciences ; Microsomes, Liver - metabolism ; Na v1.7 blockers ; NAV1.7 Voltage-Gated Sodium Channel ; Neuralgia - drug therapy ; Neuropathic pain ; Neuropathy ; Neuropharmacology ; Oxazoles - chemistry ; Oxazoles - metabolism ; Oxazoles - pharmacology ; Oxazoles - therapeutic use ; Pharmacology. Drug treatments ; Rats ; Sodium Channel Blockers - chemistry ; Sodium Channel Blockers - metabolism ; Sodium Channel Blockers - pharmacology ; Sodium Channel Blockers - therapeutic use ; Sodium Channels - metabolism ; Thiazoles - chemistry ; Thiazoles - metabolism ; Thiazoles - pharmacology ; Thiazoles - therapeutic use ; Voltage-gated sodium channel</subject><ispartof>Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (18), p.5536-5540</ispartof><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-a704446ec8a3aa18fed1ceabf5bf633c7e32ffef8c00427ef26f4ecc4f8cd8d63</citedby><cites>FETCH-LOGICAL-c417t-a704446ec8a3aa18fed1ceabf5bf633c7e32ffef8c00427ef26f4ecc4f8cd8d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960894X10010206$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23248303$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20709552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tyagarajan, Sriram</creatorcontrib><creatorcontrib>Chakravarty, Prasun K.</creatorcontrib><creatorcontrib>Zhou, Bishan</creatorcontrib><creatorcontrib>Fisher, Michael H.</creatorcontrib><creatorcontrib>Wyvratt, Mathew J.</creatorcontrib><creatorcontrib>Lyons, Kathy</creatorcontrib><creatorcontrib>Klatt, Tracy</creatorcontrib><creatorcontrib>Li, Xiaohua</creatorcontrib><creatorcontrib>Kumar, Sanjeev</creatorcontrib><creatorcontrib>Williams, Brande</creatorcontrib><creatorcontrib>Felix, John</creatorcontrib><creatorcontrib>Priest, Birgit T.</creatorcontrib><creatorcontrib>Brochu, Richard M.</creatorcontrib><creatorcontrib>Warren, Vivien</creatorcontrib><creatorcontrib>Smith, McHardy</creatorcontrib><creatorcontrib>Garcia, Maria</creatorcontrib><creatorcontrib>Kaczorowski, Gregory J.</creatorcontrib><creatorcontrib>Martin, William J.</creatorcontrib><creatorcontrib>Abbadie, Catherine</creatorcontrib><creatorcontrib>McGowan, Erin</creatorcontrib><creatorcontrib>Jochnowitz, Nina</creatorcontrib><creatorcontrib>Parsons, William H.</creatorcontrib><title>Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>A series of low molecular weight biaryl substituted oxazoles, imidazoles, and thiazoles were identified as Na
v1.7 blockers. These state dependent sodium channel blockers were synthesized and evaluated for treatment of neuropathic pain.
Voltage-gated sodium channels have been shown to play a critical role in neuropathic pain. With a goal to develop potent peripherally active sodium channel blockers, a series of low molecular weight biaryl substituted imidazoles, oxazoles, and thiazole carboxamides were identified with good in vitro and in vivo potency.</description><subject>Analgesics</subject><subject>Animals</subject><subject>Biaryl imidazoles</subject><subject>Biaryl oxazoles</subject><subject>Biaryl thiazoles</subject><subject>Biological and medical sciences</subject><subject>Dogs</subject><subject>Humans</subject><subject>Imidazoles - chemistry</subject><subject>Imidazoles - metabolism</subject><subject>Imidazoles - pharmacology</subject><subject>Imidazoles - therapeutic use</subject><subject>Medical sciences</subject><subject>Microsomes, Liver - metabolism</subject><subject>Na v1.7 blockers</subject><subject>NAV1.7 Voltage-Gated Sodium Channel</subject><subject>Neuralgia - drug therapy</subject><subject>Neuropathic pain</subject><subject>Neuropathy</subject><subject>Neuropharmacology</subject><subject>Oxazoles - chemistry</subject><subject>Oxazoles - metabolism</subject><subject>Oxazoles - pharmacology</subject><subject>Oxazoles - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Sodium Channel Blockers - chemistry</subject><subject>Sodium Channel Blockers - metabolism</subject><subject>Sodium Channel Blockers - pharmacology</subject><subject>Sodium Channel Blockers - therapeutic use</subject><subject>Sodium Channels - metabolism</subject><subject>Thiazoles - chemistry</subject><subject>Thiazoles - metabolism</subject><subject>Thiazoles - pharmacology</subject><subject>Thiazoles - therapeutic use</subject><subject>Voltage-gated sodium channel</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtv1DAQgC1ERZfCH-CAckFcyDJ-JE4kLlXFS6qEECBxs5zxWPXiJMVOUMuvx6vdwq2c5qFvHvoYe8Zhy4G3r3fbYcS4FVAaoLfQqgdsw1Wraqmgecg20LdQd736fsoe57wD4AqUesROBWjom0Zs2Ocv65CXsKwLuWoINt3Gar6xv-dI-VUVxuDucju5arkKh7KyucqzC-tY4ZWdJorVEGf8QSk_YSfexkxPj_GMfXv39uvFh_ry0_uPF-eXNSqul9rq8opqCTsrreWdJ8eR7OCbwbdSoiYpvCffIYASmrxovSJEVTquc608Yy8Pe6_T_HOlvJgxZKQY7UTzmk3fqKYXAM1_Sd2oorDXspDiQGKac07kzXUKY5FiOJi9c7Mze-dm79yANsV5GXp-XL8OI7m_I3eSC_DiCNiMNvpkJwz5HyeF6iTsr785cFS0_QqUTMZAE5ILiXAxbg73_fEHo3ehOg</recordid><startdate>20100915</startdate><enddate>20100915</enddate><creator>Tyagarajan, Sriram</creator><creator>Chakravarty, Prasun K.</creator><creator>Zhou, Bishan</creator><creator>Fisher, Michael H.</creator><creator>Wyvratt, Mathew J.</creator><creator>Lyons, Kathy</creator><creator>Klatt, Tracy</creator><creator>Li, Xiaohua</creator><creator>Kumar, Sanjeev</creator><creator>Williams, Brande</creator><creator>Felix, John</creator><creator>Priest, Birgit T.</creator><creator>Brochu, Richard M.</creator><creator>Warren, Vivien</creator><creator>Smith, McHardy</creator><creator>Garcia, Maria</creator><creator>Kaczorowski, Gregory J.</creator><creator>Martin, William J.</creator><creator>Abbadie, Catherine</creator><creator>McGowan, Erin</creator><creator>Jochnowitz, Nina</creator><creator>Parsons, William H.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20100915</creationdate><title>Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers</title><author>Tyagarajan, Sriram ; Chakravarty, Prasun K. ; Zhou, Bishan ; Fisher, Michael H. ; Wyvratt, Mathew J. ; Lyons, Kathy ; Klatt, Tracy ; Li, Xiaohua ; Kumar, Sanjeev ; Williams, Brande ; Felix, John ; Priest, Birgit T. ; Brochu, Richard M. ; Warren, Vivien ; Smith, McHardy ; Garcia, Maria ; Kaczorowski, Gregory J. ; Martin, William J. ; Abbadie, Catherine ; McGowan, Erin ; Jochnowitz, Nina ; Parsons, William H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-a704446ec8a3aa18fed1ceabf5bf633c7e32ffef8c00427ef26f4ecc4f8cd8d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Analgesics</topic><topic>Animals</topic><topic>Biaryl imidazoles</topic><topic>Biaryl oxazoles</topic><topic>Biaryl thiazoles</topic><topic>Biological and medical sciences</topic><topic>Dogs</topic><topic>Humans</topic><topic>Imidazoles - chemistry</topic><topic>Imidazoles - metabolism</topic><topic>Imidazoles - pharmacology</topic><topic>Imidazoles - therapeutic use</topic><topic>Medical sciences</topic><topic>Microsomes, Liver - metabolism</topic><topic>Na v1.7 blockers</topic><topic>NAV1.7 Voltage-Gated Sodium Channel</topic><topic>Neuralgia - drug therapy</topic><topic>Neuropathic pain</topic><topic>Neuropathy</topic><topic>Neuropharmacology</topic><topic>Oxazoles - chemistry</topic><topic>Oxazoles - metabolism</topic><topic>Oxazoles - pharmacology</topic><topic>Oxazoles - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Sodium Channel Blockers - chemistry</topic><topic>Sodium Channel Blockers - metabolism</topic><topic>Sodium Channel Blockers - pharmacology</topic><topic>Sodium Channel Blockers - therapeutic use</topic><topic>Sodium Channels - metabolism</topic><topic>Thiazoles - chemistry</topic><topic>Thiazoles - metabolism</topic><topic>Thiazoles - pharmacology</topic><topic>Thiazoles - therapeutic use</topic><topic>Voltage-gated sodium channel</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tyagarajan, Sriram</creatorcontrib><creatorcontrib>Chakravarty, Prasun K.</creatorcontrib><creatorcontrib>Zhou, Bishan</creatorcontrib><creatorcontrib>Fisher, Michael H.</creatorcontrib><creatorcontrib>Wyvratt, Mathew J.</creatorcontrib><creatorcontrib>Lyons, Kathy</creatorcontrib><creatorcontrib>Klatt, Tracy</creatorcontrib><creatorcontrib>Li, Xiaohua</creatorcontrib><creatorcontrib>Kumar, Sanjeev</creatorcontrib><creatorcontrib>Williams, Brande</creatorcontrib><creatorcontrib>Felix, John</creatorcontrib><creatorcontrib>Priest, Birgit T.</creatorcontrib><creatorcontrib>Brochu, Richard M.</creatorcontrib><creatorcontrib>Warren, Vivien</creatorcontrib><creatorcontrib>Smith, McHardy</creatorcontrib><creatorcontrib>Garcia, Maria</creatorcontrib><creatorcontrib>Kaczorowski, Gregory J.</creatorcontrib><creatorcontrib>Martin, William J.</creatorcontrib><creatorcontrib>Abbadie, Catherine</creatorcontrib><creatorcontrib>McGowan, Erin</creatorcontrib><creatorcontrib>Jochnowitz, Nina</creatorcontrib><creatorcontrib>Parsons, William H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tyagarajan, Sriram</au><au>Chakravarty, Prasun K.</au><au>Zhou, Bishan</au><au>Fisher, Michael H.</au><au>Wyvratt, Mathew J.</au><au>Lyons, Kathy</au><au>Klatt, Tracy</au><au>Li, Xiaohua</au><au>Kumar, Sanjeev</au><au>Williams, Brande</au><au>Felix, John</au><au>Priest, Birgit T.</au><au>Brochu, Richard M.</au><au>Warren, Vivien</au><au>Smith, McHardy</au><au>Garcia, Maria</au><au>Kaczorowski, Gregory J.</au><au>Martin, William J.</au><au>Abbadie, Catherine</au><au>McGowan, Erin</au><au>Jochnowitz, Nina</au><au>Parsons, William H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2010-09-15</date><risdate>2010</risdate><volume>20</volume><issue>18</issue><spage>5536</spage><epage>5540</epage><pages>5536-5540</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>A series of low molecular weight biaryl substituted oxazoles, imidazoles, and thiazoles were identified as Na
v1.7 blockers. These state dependent sodium channel blockers were synthesized and evaluated for treatment of neuropathic pain.
Voltage-gated sodium channels have been shown to play a critical role in neuropathic pain. With a goal to develop potent peripherally active sodium channel blockers, a series of low molecular weight biaryl substituted imidazoles, oxazoles, and thiazole carboxamides were identified with good in vitro and in vivo potency.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>20709552</pmid><doi>10.1016/j.bmcl.2010.07.064</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (18), p.5536-5540 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_954592005 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Analgesics Animals Biaryl imidazoles Biaryl oxazoles Biaryl thiazoles Biological and medical sciences Dogs Humans Imidazoles - chemistry Imidazoles - metabolism Imidazoles - pharmacology Imidazoles - therapeutic use Medical sciences Microsomes, Liver - metabolism Na v1.7 blockers NAV1.7 Voltage-Gated Sodium Channel Neuralgia - drug therapy Neuropathic pain Neuropathy Neuropharmacology Oxazoles - chemistry Oxazoles - metabolism Oxazoles - pharmacology Oxazoles - therapeutic use Pharmacology. Drug treatments Rats Sodium Channel Blockers - chemistry Sodium Channel Blockers - metabolism Sodium Channel Blockers - pharmacology Sodium Channel Blockers - therapeutic use Sodium Channels - metabolism Thiazoles - chemistry Thiazoles - metabolism Thiazoles - pharmacology Thiazoles - therapeutic use Voltage-gated sodium channel |
| title | Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T20%3A31%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Substituted%20biaryl%20oxazoles,%20imidazoles,%20and%20thiazoles%20as%20sodium%20channel%20blockers&rft.jtitle=Bioorganic%20&%20medicinal%20chemistry%20letters&rft.au=Tyagarajan,%20Sriram&rft.date=2010-09-15&rft.volume=20&rft.issue=18&rft.spage=5536&rft.epage=5540&rft.pages=5536-5540&rft.issn=0960-894X&rft.eissn=1464-3405&rft_id=info:doi/10.1016/j.bmcl.2010.07.064&rft_dat=%3Cproquest_cross%3E954592005%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=754010973&rft_id=info:pmid/20709552&rft_els_id=S0960894X10010206&rfr_iscdi=true |