Knockdown of FoxO3a induces increased neuronal apoptosis during embryonic development in zebrafish

Neuronal apoptosis sculpts the developing brain, and nearly all identified classes of neurons seem to be produced “in excess” during development. FoxO transcription factors regulate apoptosis in vitro in deprived of neurotrophins. It is unknown if FoxO3a is involved in the development of neurons. He...

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Veröffentlicht in:	Neuroscience letters 2010-10, Vol.484 (2), p.98-103
Hauptverfasser:	Peng, Kou, Li, Yi, Long, Ling, Li, Dong, Jia, Qiuli, Wang, Yidong, Shen, Qingyu, Tang, Yamei, Wen, Lu, Kung, Hsiang-fu, Peng, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridine orange Amino Acid Sequence Animals Animals, Genetically Modified Apoptosis Apoptosis - drug effects Apoptosis - genetics Biological and medical sciences Brain Brain - cytology Brain - embryology Danio rerio Development Embryo, Nonmammalian Embryonic Development - drug effects Embryonic Development - physiology Forkhead Transcription Factors - chemistry Forkhead Transcription Factors - deficiency Forkhead Transcription Factors - genetics FoxO3a Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental - drug effects Gene Knockdown Techniques Green Fluorescent Proteins - genetics Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neural Cell Adhesion Molecules - genetics Neural Cell Adhesion Molecules - metabolism Neurons - drug effects Neurons - physiology Oligonucleotides, Antisense - pharmacology RNA, Messenger - metabolism Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Vertebrates: nervous system and sense organs Zebrafish Zebrafish Proteins - chemistry Zebrafish Proteins - deficiency Zebrafish Proteins - genetics
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