Gender differences in the relationship between the risperidone metabolism and the plasma prolactin levels in psychiatric patients

Risperidone (RIS) has the highest propensity to elevate plasma prolactin (PRL) levels. While the active metabolite 9-hydroxy-risperidone (9-OH-RIS) plays a predominant role in the efficacy and side effects of RIS, the mechanistic details are still poorly understood. The present study evaluated the g...

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Veröffentlicht in:	Progress in neuro-psychopharmacology & biological psychiatry 2010-10, Vol.34 (7), p.1266-1268
Hauptverfasser:	Suzuki, Yutaro, Fukui, Naoki, Watanabe, Junzo, Ono, Shin, Sugai, Takuro, Tsuneyama, Nobuto, Inoue, Yoshimasa, Someya, Toshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	9-OH-risperidone Adult Aged Biological and medical sciences Chromatography, Liquid - methods Enzyme-Linked Immunosorbent Assay - methods Female Humans Isoxazoles - blood Male Medical sciences Mental Disorders - drug therapy Mental Disorders - metabolism Metabolism Middle Aged Neuropharmacology Paliperidone Palmitate Pharmacodynamics Pharmacokinetics Pharmacology. Drug treatments Plasma concentration Prolactin - blood Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Pyrimidines - blood Risperidone - metabolism Risperidone - therapeutic use Sex Characteristics Side effect Tandem Mass Spectrometry - methods Young Adult
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