Mammalian circadian clock system: Molecular mechanisms for pharmaceutical and medical sciences
An internal circadian (from the Latin “ circa” meaning “about” and “ dien” meaning “day”) clock has been found across kingdoms of life, a testimony that circadian rhythms are a basic feature of life on earth. Physiologically relevant circadian time is generated at the level of transcription–(post)tr...
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| Veröffentlicht in: | Advanced drug delivery reviews 2010-07, Vol.62 (9), p.876-884 |
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| creator | Okamura, Hitoshi Doi, Masao Fustin, Jean-Michel Yamaguchi, Yoshiaki Matsuo, Masahiro |
| description | An internal circadian (from the Latin “
circa” meaning “about” and “
dien” meaning “day”) clock has been found across kingdoms of life, a testimony that circadian rhythms are a basic feature of life on earth. Physiologically relevant circadian time is generated at the level of transcription–(post)translation feedback loop of clock genes, which machinery can be found in most cells throughout the body. Lesions of the hypothalamic suprachiasmatic nucleus (SCN) abolish clock oscillations in the body, indicating thereby that rhythm generation is a hierarchial system with the SCN at the top. Disrupting this exquisitely harmonious system causes abnormal expression of cell-type specific clock-controlled genes, as revealed by the etiology of life-style related diseases such as hypertension. |
| doi_str_mv | 10.1016/j.addr.2010.06.004 |
| format | Article |
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circa” meaning “about” and “
dien” meaning “day”) clock has been found across kingdoms of life, a testimony that circadian rhythms are a basic feature of life on earth. Physiologically relevant circadian time is generated at the level of transcription–(post)translation feedback loop of clock genes, which machinery can be found in most cells throughout the body. Lesions of the hypothalamic suprachiasmatic nucleus (SCN) abolish clock oscillations in the body, indicating thereby that rhythm generation is a hierarchial system with the SCN at the top. 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| fulltext | fulltext |
| identifier | ISSN: 0169-409X |
| ispartof | Advanced drug delivery reviews, 2010-07, Vol.62 (9), p.876-884 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Circadian Clocks - physiology Circadian rhythm Circadian Rhythm Signaling Peptides and Proteins - metabolism Clock genes CLOCK protein Clock-controlled genes Humans Hypertension Hypertension - etiology Life Style Peripheral clock Suprachiasmatic nucleus Suprachiasmatic Nucleus - pathology Suprachiasmatic Nucleus - physiology Transcription, Genetic Transcription–translation feedback loop |
| title | Mammalian circadian clock system: Molecular mechanisms for pharmaceutical and medical sciences |
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