Asthma: Chronopharmacotherapy and the molecular clock

Bronchial asthma is characterized by chronic airways inflammation and reversible airflow limitation. In patients with asthma, symptoms generally worsen during the early hours of the morning, and pulmonary function often deteriorates at the same time, suggesting a role for chronopharmacotherapy. Seve...

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Veröffentlicht in:	Advanced drug delivery reviews 2010-07, Vol.62 (9), p.946-955
Hauptverfasser:	Burioka, Naoto, Fukuoka, Yasushi, Koyanagi, Satoru, Miyata, Masanori, Takata, Miyako, Chikumi, Hiroki, Takane, Hiroshi, Watanabe, Masanari, Endo, Masahiro, Sako, Takanori, Suyama, Hisashi, Ohdo, Shigehiro, Shimizu, Eiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asthma - drug therapy Asthma - physiopathology Bronchial asthma Bronchodilator Agents - administration & dosage Bronchodilator Agents - therapeutic use Chronopharmacology Chronotherapy Circadian Clocks - physiology Circadian rhythm Clock gene Drug Administration Schedule Drug Chronotherapy Glucocorticoid Glucocorticoids - administration & dosage Glucocorticoids - therapeutic use Humans Hypoxia Medication Adherence Theophylline Time Factors β 2-adrenoceptor agonist
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