AXIS A Trial of Intravenous Granulocyte Colony-Stimulating Factor in Acute Ischemic Stroke

Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present phase IIa study assessed safety and tolerability over a broad dose range of G-CSF doses in acute ischemic stroke patients and explored outcome data. Four intravenous dose regimens (total cumulative doses...

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Veröffentlicht in:	Stroke (1970) 2010-11, Vol.41 (11), p.2545-2551
Hauptverfasser:	SCHÄBITZ, Wolf R, LAAGE, Rico, FIEBACH, Jochen B, HACKE, Werner, GROTTA, James C, FISHER, Marc, SCHNEIDER, Armin, VOGT, Gerhard, KOCH, Winfried, KOLLMAR, Rainer, SCHWAB, Stefan, SCHNEIDER, Dietmar, HAMANN, Gerhard F, ROSENKRANZ, Michael, VELTKAMP, Roland
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Cell Count Dose-Response Relationship, Drug Double-Blind Method Emergency and intensive care: comas and nervous system diseases Feasibility Studies Female Germany Granulocyte Colony-Stimulating Factor - administration & dosage Granulocyte Colony-Stimulating Factor - adverse effects Granulocyte Colony-Stimulating Factor - therapeutic use Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Injections, Intravenous Intensive care medicine Leukocytes - pathology Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Pharmacology. Drug treatments Stroke - drug therapy Stroke - pathology Stroke - physiopathology Treatment Outcome Vascular diseases and vascular malformations of the nervous system
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