Effects of dehydration-induced structural and material changes on the apparent modulus of cancellous bone
Abstract Dehydration is known to cause an increase in the elastic modulus of bone tissue. However, it also causes structural changes (i.e. shrinkage) which can themselves significantly alter the mechanical properties, particularly in cancellous bone. The current study attempts to estimate the contri...
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| Veröffentlicht in: | Medical engineering & physics 2010-10, Vol.32 (8), p.921-925 |
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| creator | Lievers, W.B Poljsak, A.S Waldman, S.D Pilkey, A.K |
| description | Abstract Dehydration is known to cause an increase in the elastic modulus of bone tissue. However, it also causes structural changes (i.e. shrinkage) which can themselves significantly alter the mechanical properties, particularly in cancellous bone. The current study attempts to estimate the contribution of these two competing factors to the net change of dehydration on the apparent modulus of bovine cancellous bone. Cylindrical cores from the lumbar vertebrae were tested in tension, while hydrated and again after dehydration. The bone volume fractions (BV/TV) were measured in both conditions. The results indicate that the average overall increase in the apparent modulus after dehydration is 14 ± 14% (mean ± SD), which represents the net effect of a 27% increase in modulus due to increased tissue modulus offset by a modulus decrease of 13% due to reductions in bone volume fraction. These observations underscore the need to consider both structural and material changes when comparing hydrated and dehydrated mechanical behaviour. |
| doi_str_mv | 10.1016/j.medengphy.2010.06.001 |
| format | Article |
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However, it also causes structural changes (i.e. shrinkage) which can themselves significantly alter the mechanical properties, particularly in cancellous bone. The current study attempts to estimate the contribution of these two competing factors to the net change of dehydration on the apparent modulus of bovine cancellous bone. Cylindrical cores from the lumbar vertebrae were tested in tension, while hydrated and again after dehydration. The bone volume fractions (BV/TV) were measured in both conditions. The results indicate that the average overall increase in the apparent modulus after dehydration is 14 ± 14% (mean ± SD), which represents the net effect of a 27% increase in modulus due to increased tissue modulus offset by a modulus decrease of 13% due to reductions in bone volume fraction. These observations underscore the need to consider both structural and material changes when comparing hydrated and dehydrated mechanical behaviour.</description><identifier>ISSN: 1350-4533</identifier><identifier>EISSN: 1873-4030</identifier><identifier>DOI: 10.1016/j.medengphy.2010.06.001</identifier><identifier>PMID: 20638319</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Atrophy ; Biological and medical sciences ; Biomechanical Phenomena ; Bone and Bones - metabolism ; Bone and Bones - pathology ; Bone and Bones - physiopathology ; Calcification, Physiologic ; Cancellous bone ; Cattle ; Dehydration ; Dehydration - metabolism ; Dehydration - pathology ; Dehydration - physiopathology ; Elastic Modulus ; Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition ; Humans ; Intensive care medicine ; Lumbar Vertebrae - metabolism ; Lumbar Vertebrae - pathology ; Lumbar Vertebrae - physiopathology ; Medical sciences ; Radiology ; Water - metabolism ; Water phase</subject><ispartof>Medical engineering & physics, 2010-10, Vol.32 (8), p.921-925</ispartof><rights>2010</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-3098fccacc11c105c2234d5d74a2d778e005c17c304fe803ed7e75360fcbd7d13</citedby><cites>FETCH-LOGICAL-c487t-3098fccacc11c105c2234d5d74a2d778e005c17c304fe803ed7e75360fcbd7d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.medengphy.2010.06.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23259440$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20638319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lievers, W.B</creatorcontrib><creatorcontrib>Poljsak, A.S</creatorcontrib><creatorcontrib>Waldman, S.D</creatorcontrib><creatorcontrib>Pilkey, A.K</creatorcontrib><title>Effects of dehydration-induced structural and material changes on the apparent modulus of cancellous bone</title><title>Medical engineering & physics</title><addtitle>Med Eng Phys</addtitle><description>Abstract Dehydration is known to cause an increase in the elastic modulus of bone tissue. However, it also causes structural changes (i.e. shrinkage) which can themselves significantly alter the mechanical properties, particularly in cancellous bone. The current study attempts to estimate the contribution of these two competing factors to the net change of dehydration on the apparent modulus of bovine cancellous bone. Cylindrical cores from the lumbar vertebrae were tested in tension, while hydrated and again after dehydration. The bone volume fractions (BV/TV) were measured in both conditions. The results indicate that the average overall increase in the apparent modulus after dehydration is 14 ± 14% (mean ± SD), which represents the net effect of a 27% increase in modulus due to increased tissue modulus offset by a modulus decrease of 13% due to reductions in bone volume fraction. These observations underscore the need to consider both structural and material changes when comparing hydrated and dehydrated mechanical behaviour.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Atrophy</subject><subject>Biological and medical sciences</subject><subject>Biomechanical Phenomena</subject><subject>Bone and Bones - metabolism</subject><subject>Bone and Bones - pathology</subject><subject>Bone and Bones - physiopathology</subject><subject>Calcification, Physiologic</subject><subject>Cancellous bone</subject><subject>Cattle</subject><subject>Dehydration</subject><subject>Dehydration - metabolism</subject><subject>Dehydration - pathology</subject><subject>Dehydration - physiopathology</subject><subject>Elastic Modulus</subject><subject>Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Lumbar Vertebrae - metabolism</subject><subject>Lumbar Vertebrae - pathology</subject><subject>Lumbar Vertebrae - physiopathology</subject><subject>Medical sciences</subject><subject>Radiology</subject><subject>Water - metabolism</subject><subject>Water phase</subject><issn>1350-4533</issn><issn>1873-4030</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhi0EomXhL0AuiFOWcWzHyQWpqsqHVIkDcLa89qTrJXGCnVTaf8-EXYrEBU72jJ750PsOY684bDnw-u1hO6DHeDftj9sKKAv1FoA_Ype80aKUIOAx_YWCUiohLtiznA8AIGUtnrKLCmrRCN5esnDTdejmXIxd4XF_9MnOYYxliH5x6Is8p8XNS7J9YaMvBjtjChS4vY13SGWxmPdY2GmyCeNcDKNf-uVXO2ejw74fKdqNEZ-zJ53tM744vxv27f3N1-uP5e3nD5-ur25LJxs9lwLapnPOOse546BcVQnpldfSVl7rBoFyXDsBssMGBHqNWokaOrfz2nOxYW9Ofac0_lgwz2YIeV3ERqRdTKukajknBf5FaiUBatkIIvWJdGnMOWFnphQGm46Gg1kNMQfzYIhZDTFQGzKEKl-eZyw7Ih7qfjtAwOszYLOzfZdItZD_cKJSrSQ_N-zqxCFpdx8wmewCksI-JDLQ-DH8xzLv_urh-hADjf2OR8yHcUmRrDHc5MqA-bLez3o-nC6H86YVPwE4_MNp</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Lievers, W.B</creator><creator>Poljsak, A.S</creator><creator>Waldman, S.D</creator><creator>Pilkey, A.K</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20101001</creationdate><title>Effects of dehydration-induced structural and material changes on the apparent modulus of cancellous bone</title><author>Lievers, W.B ; Poljsak, A.S ; Waldman, S.D ; Pilkey, A.K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-3098fccacc11c105c2234d5d74a2d778e005c17c304fe803ed7e75360fcbd7d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Atrophy</topic><topic>Biological and medical sciences</topic><topic>Biomechanical Phenomena</topic><topic>Bone and Bones - metabolism</topic><topic>Bone and Bones - pathology</topic><topic>Bone and Bones - physiopathology</topic><topic>Calcification, Physiologic</topic><topic>Cancellous bone</topic><topic>Cattle</topic><topic>Dehydration</topic><topic>Dehydration - metabolism</topic><topic>Dehydration - pathology</topic><topic>Dehydration - physiopathology</topic><topic>Elastic Modulus</topic><topic>Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Lumbar Vertebrae - metabolism</topic><topic>Lumbar Vertebrae - pathology</topic><topic>Lumbar Vertebrae - physiopathology</topic><topic>Medical sciences</topic><topic>Radiology</topic><topic>Water - metabolism</topic><topic>Water phase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lievers, W.B</creatorcontrib><creatorcontrib>Poljsak, A.S</creatorcontrib><creatorcontrib>Waldman, S.D</creatorcontrib><creatorcontrib>Pilkey, A.K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Medical engineering & physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lievers, W.B</au><au>Poljsak, A.S</au><au>Waldman, S.D</au><au>Pilkey, A.K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of dehydration-induced structural and material changes on the apparent modulus of cancellous bone</atitle><jtitle>Medical engineering & physics</jtitle><addtitle>Med Eng Phys</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>32</volume><issue>8</issue><spage>921</spage><epage>925</epage><pages>921-925</pages><issn>1350-4533</issn><eissn>1873-4030</eissn><abstract>Abstract Dehydration is known to cause an increase in the elastic modulus of bone tissue. However, it also causes structural changes (i.e. shrinkage) which can themselves significantly alter the mechanical properties, particularly in cancellous bone. The current study attempts to estimate the contribution of these two competing factors to the net change of dehydration on the apparent modulus of bovine cancellous bone. Cylindrical cores from the lumbar vertebrae were tested in tension, while hydrated and again after dehydration. The bone volume fractions (BV/TV) were measured in both conditions. The results indicate that the average overall increase in the apparent modulus after dehydration is 14 ± 14% (mean ± SD), which represents the net effect of a 27% increase in modulus due to increased tissue modulus offset by a modulus decrease of 13% due to reductions in bone volume fraction. These observations underscore the need to consider both structural and material changes when comparing hydrated and dehydrated mechanical behaviour.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>20638319</pmid><doi>10.1016/j.medengphy.2010.06.001</doi><tpages>5</tpages></addata></record> |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Atrophy Biological and medical sciences Biomechanical Phenomena Bone and Bones - metabolism Bone and Bones - pathology Bone and Bones - physiopathology Calcification, Physiologic Cancellous bone Cattle Dehydration Dehydration - metabolism Dehydration - pathology Dehydration - physiopathology Elastic Modulus Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition Humans Intensive care medicine Lumbar Vertebrae - metabolism Lumbar Vertebrae - pathology Lumbar Vertebrae - physiopathology Medical sciences Radiology Water - metabolism Water phase |
| title | Effects of dehydration-induced structural and material changes on the apparent modulus of cancellous bone |
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