Nitric oxide mediated recovery sleep is attenuated with aging
Abstract Nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) in the cholinergic basal forebrain (BF) during sleep deprivation (SD) is implicated in adenosine (AD) release and induction of recovery sleep. Aging is associated with impairments in sleep homeostasis, such as decrease in...
Gespeichert in:
| Veröffentlicht in: | Neurobiology of aging 2010-11, Vol.31 (11), p.2011-2019 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2019 |
|---|---|
| container_issue | 11 |
| container_start_page | 2011 |
| container_title | Neurobiology of aging |
| container_volume | 31 |
| creator | Rytkönen, Kirsi-Marja Wigren, Henna-Kaisa Kostin, Andrey Porkka-Heiskanen, Tarja Kalinchuk, Anna V |
| description | Abstract Nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) in the cholinergic basal forebrain (BF) during sleep deprivation (SD) is implicated in adenosine (AD) release and induction of recovery sleep. Aging is associated with impairments in sleep homeostasis, such as decrease in non-rapid eye movement sleep (NREM) intensity following SD. We hypothesized that age related changes in sleep homeostasis may be induced by impairments in NO-mediated sleep induction. To test this hypothesis we measured levels of NO and iNOS in the BF during SD as well as recovery sleep after SD and NO-donor (DETA/NO) infusion into the BF in three age groups of rats (young, 4 months; middle-aged, 14 months; old, 24 months). We found that in aged rats as compared to young (1) recovery NREM sleep intensity was significantly decreased, (2) neither iNOS nor NO increased in the BF during SD, and (3) DETA/NO infusion failed to induce sleep. Together, these results support our hypothesis that aging impairs the mechanism through which NO in the BF induces sleep. |
| doi_str_mv | 10.1016/j.neurobiolaging.2008.10.006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_954590548</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0197458008003709</els_id><sourcerecordid>954590548</sourcerecordid><originalsourceid>FETCH-LOGICAL-c502t-3da2b94cdf170d7047354a4b044fdc968938cf951f9f2a7c5c6926be0f29f60f3</originalsourceid><addsrcrecordid>eNqNkkGPFCEQhYnRuOPqXzB90HjqsaChgUQ3MRtXTTZ6UM-EpouVsacZoXt1_r30zESjF01IOLyv6sGrIuQJhTUF2j7frEecU-xCHOxNGG_WDEAVaQ3Q3iErKoSqKdfyLlkB1bLmQsEZeZDzBgAkl-19ckY1CKUUrMjL92FKwVXxR-ix2mIf7IR9ldDFW0z7Kg-Iuyrkyk4TjvNB_B6mL9XB-yG55-2Q8dHpPiefr15_unxbX3948-7y1XXtBLCpbnrLOs1d76mEXgKXjeCWd8C5751ulW6U81pQrz2z0gnXatZ2CJ5p34JvzsmzY99dit9mzJPZhuxwGOyIcc5GCy7Kl7j6JymF4ECLYSFfHEmXYs4JvdmlsLVpbyiYJWmzMX8mbZakF7UkXcofn4zmrsT2u_gUbQGengCbnR18sqML-RfHmgY0O3BXRw5LgLcBk8ku4OjKKMoUJtPH8L8vuvirkRvCGIr3V9xj3sQ5jWVIhprMDJiPy3YsywHlNBJ08xNIIrk5</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>755401893</pqid></control><display><type>article</type><title>Nitric oxide mediated recovery sleep is attenuated with aging</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Rytkönen, Kirsi-Marja ; Wigren, Henna-Kaisa ; Kostin, Andrey ; Porkka-Heiskanen, Tarja ; Kalinchuk, Anna V</creator><creatorcontrib>Rytkönen, Kirsi-Marja ; Wigren, Henna-Kaisa ; Kostin, Andrey ; Porkka-Heiskanen, Tarja ; Kalinchuk, Anna V</creatorcontrib><description>Abstract Nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) in the cholinergic basal forebrain (BF) during sleep deprivation (SD) is implicated in adenosine (AD) release and induction of recovery sleep. Aging is associated with impairments in sleep homeostasis, such as decrease in non-rapid eye movement sleep (NREM) intensity following SD. We hypothesized that age related changes in sleep homeostasis may be induced by impairments in NO-mediated sleep induction. To test this hypothesis we measured levels of NO and iNOS in the BF during SD as well as recovery sleep after SD and NO-donor (DETA/NO) infusion into the BF in three age groups of rats (young, 4 months; middle-aged, 14 months; old, 24 months). We found that in aged rats as compared to young (1) recovery NREM sleep intensity was significantly decreased, (2) neither iNOS nor NO increased in the BF during SD, and (3) DETA/NO infusion failed to induce sleep. Together, these results support our hypothesis that aging impairs the mechanism through which NO in the BF induces sleep.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2008.10.006</identifier><identifier>PMID: 19058880</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Adenosine ; Aging ; Aging - physiology ; Animals ; Biological and medical sciences ; Development. Senescence. Regeneration. Transplantation ; Fundamental and applied biological sciences. Psychology ; Inducible nitric oxide ; Internal Medicine ; Male ; Microdialysis ; Neurology ; Nitric oxide ; Nitric Oxide - metabolism ; Nitric Oxide Synthase Type II - metabolism ; Prosencephalon - metabolism ; Rats ; Rats, Wistar ; Sleep ; Sleep - physiology ; Sleep deprivation ; Sleep Deprivation - metabolism ; Sleep homeostasis ; Sleep Stages - physiology ; Sleep. Vigilance ; Vertebrates: nervous system and sense organs</subject><ispartof>Neurobiology of aging, 2010-11, Vol.31 (11), p.2011-2019</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2008 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-3da2b94cdf170d7047354a4b044fdc968938cf951f9f2a7c5c6926be0f29f60f3</citedby><cites>FETCH-LOGICAL-c502t-3da2b94cdf170d7047354a4b044fdc968938cf951f9f2a7c5c6926be0f29f60f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neurobiolaging.2008.10.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23309280$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19058880$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rytkönen, Kirsi-Marja</creatorcontrib><creatorcontrib>Wigren, Henna-Kaisa</creatorcontrib><creatorcontrib>Kostin, Andrey</creatorcontrib><creatorcontrib>Porkka-Heiskanen, Tarja</creatorcontrib><creatorcontrib>Kalinchuk, Anna V</creatorcontrib><title>Nitric oxide mediated recovery sleep is attenuated with aging</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Abstract Nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) in the cholinergic basal forebrain (BF) during sleep deprivation (SD) is implicated in adenosine (AD) release and induction of recovery sleep. Aging is associated with impairments in sleep homeostasis, such as decrease in non-rapid eye movement sleep (NREM) intensity following SD. We hypothesized that age related changes in sleep homeostasis may be induced by impairments in NO-mediated sleep induction. To test this hypothesis we measured levels of NO and iNOS in the BF during SD as well as recovery sleep after SD and NO-donor (DETA/NO) infusion into the BF in three age groups of rats (young, 4 months; middle-aged, 14 months; old, 24 months). We found that in aged rats as compared to young (1) recovery NREM sleep intensity was significantly decreased, (2) neither iNOS nor NO increased in the BF during SD, and (3) DETA/NO infusion failed to induce sleep. Together, these results support our hypothesis that aging impairs the mechanism through which NO in the BF induces sleep.</description><subject>Adenosine</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Inducible nitric oxide</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Microdialysis</subject><subject>Neurology</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitric Oxide Synthase Type II - metabolism</subject><subject>Prosencephalon - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sleep</subject><subject>Sleep - physiology</subject><subject>Sleep deprivation</subject><subject>Sleep Deprivation - metabolism</subject><subject>Sleep homeostasis</subject><subject>Sleep Stages - physiology</subject><subject>Sleep. Vigilance</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkGPFCEQhYnRuOPqXzB90HjqsaChgUQ3MRtXTTZ6UM-EpouVsacZoXt1_r30zESjF01IOLyv6sGrIuQJhTUF2j7frEecU-xCHOxNGG_WDEAVaQ3Q3iErKoSqKdfyLlkB1bLmQsEZeZDzBgAkl-19ckY1CKUUrMjL92FKwVXxR-ix2mIf7IR9ldDFW0z7Kg-Iuyrkyk4TjvNB_B6mL9XB-yG55-2Q8dHpPiefr15_unxbX3948-7y1XXtBLCpbnrLOs1d76mEXgKXjeCWd8C5751ulW6U81pQrz2z0gnXatZ2CJ5p34JvzsmzY99dit9mzJPZhuxwGOyIcc5GCy7Kl7j6JymF4ECLYSFfHEmXYs4JvdmlsLVpbyiYJWmzMX8mbZakF7UkXcofn4zmrsT2u_gUbQGengCbnR18sqML-RfHmgY0O3BXRw5LgLcBk8ku4OjKKMoUJtPH8L8vuvirkRvCGIr3V9xj3sQ5jWVIhprMDJiPy3YsywHlNBJ08xNIIrk5</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Rytkönen, Kirsi-Marja</creator><creator>Wigren, Henna-Kaisa</creator><creator>Kostin, Andrey</creator><creator>Porkka-Heiskanen, Tarja</creator><creator>Kalinchuk, Anna V</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20101101</creationdate><title>Nitric oxide mediated recovery sleep is attenuated with aging</title><author>Rytkönen, Kirsi-Marja ; Wigren, Henna-Kaisa ; Kostin, Andrey ; Porkka-Heiskanen, Tarja ; Kalinchuk, Anna V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-3da2b94cdf170d7047354a4b044fdc968938cf951f9f2a7c5c6926be0f29f60f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adenosine</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Inducible nitric oxide</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Microdialysis</topic><topic>Neurology</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitric Oxide Synthase Type II - metabolism</topic><topic>Prosencephalon - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sleep</topic><topic>Sleep - physiology</topic><topic>Sleep deprivation</topic><topic>Sleep Deprivation - metabolism</topic><topic>Sleep homeostasis</topic><topic>Sleep Stages - physiology</topic><topic>Sleep. Vigilance</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rytkönen, Kirsi-Marja</creatorcontrib><creatorcontrib>Wigren, Henna-Kaisa</creatorcontrib><creatorcontrib>Kostin, Andrey</creatorcontrib><creatorcontrib>Porkka-Heiskanen, Tarja</creatorcontrib><creatorcontrib>Kalinchuk, Anna V</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rytkönen, Kirsi-Marja</au><au>Wigren, Henna-Kaisa</au><au>Kostin, Andrey</au><au>Porkka-Heiskanen, Tarja</au><au>Kalinchuk, Anna V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nitric oxide mediated recovery sleep is attenuated with aging</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>31</volume><issue>11</issue><spage>2011</spage><epage>2019</epage><pages>2011-2019</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>Abstract Nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) in the cholinergic basal forebrain (BF) during sleep deprivation (SD) is implicated in adenosine (AD) release and induction of recovery sleep. Aging is associated with impairments in sleep homeostasis, such as decrease in non-rapid eye movement sleep (NREM) intensity following SD. We hypothesized that age related changes in sleep homeostasis may be induced by impairments in NO-mediated sleep induction. To test this hypothesis we measured levels of NO and iNOS in the BF during SD as well as recovery sleep after SD and NO-donor (DETA/NO) infusion into the BF in three age groups of rats (young, 4 months; middle-aged, 14 months; old, 24 months). We found that in aged rats as compared to young (1) recovery NREM sleep intensity was significantly decreased, (2) neither iNOS nor NO increased in the BF during SD, and (3) DETA/NO infusion failed to induce sleep. Together, these results support our hypothesis that aging impairs the mechanism through which NO in the BF induces sleep.</abstract><cop>London</cop><pub>Elsevier Inc</pub><pmid>19058880</pmid><doi>10.1016/j.neurobiolaging.2008.10.006</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0197-4580 |
| ispartof | Neurobiology of aging, 2010-11, Vol.31 (11), p.2011-2019 |
| issn | 0197-4580 1558-1497 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_954590548 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adenosine Aging Aging - physiology Animals Biological and medical sciences Development. Senescence. Regeneration. Transplantation Fundamental and applied biological sciences. Psychology Inducible nitric oxide Internal Medicine Male Microdialysis Neurology Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Prosencephalon - metabolism Rats Rats, Wistar Sleep Sleep - physiology Sleep deprivation Sleep Deprivation - metabolism Sleep homeostasis Sleep Stages - physiology Sleep. Vigilance Vertebrates: nervous system and sense organs |
| title | Nitric oxide mediated recovery sleep is attenuated with aging |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T06%3A35%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nitric%20oxide%20mediated%20recovery%20sleep%20is%20attenuated%20with%20aging&rft.jtitle=Neurobiology%20of%20aging&rft.au=Rytk%C3%B6nen,%20Kirsi-Marja&rft.date=2010-11-01&rft.volume=31&rft.issue=11&rft.spage=2011&rft.epage=2019&rft.pages=2011-2019&rft.issn=0197-4580&rft.eissn=1558-1497&rft.coden=NEAGDO&rft_id=info:doi/10.1016/j.neurobiolaging.2008.10.006&rft_dat=%3Cproquest_cross%3E954590548%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=755401893&rft_id=info:pmid/19058880&rft_els_id=1_s2_0_S0197458008003709&rfr_iscdi=true |