High-dose methotrexate with or without whole brain radiotherapy for primary lymphoma (G NSL-SG-1): a phase 3, randomised, non-inferiority trial

High-dose methotrexate is the standard of care for patients with newly diagnosed primary lymphoma. The role of whole brain radiotherapy is controversial because delayed neurotoxicity limits its acceptance as a standard of care. We aimed to investigate whether first-line chemotherapy based on high-do...

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Veröffentlicht in:	The lancet oncology 2010-11, Vol.11 (11), p.1036-1047
Hauptverfasser:	Thiel, Eckhard, Korfel, Agnieszka, Martus, Peter, Kanz, Lothar, Griesinger, Frank, Rauch, Michael, Roeth, Alexander, Hertenstein, Bernd, Von Toll, Theda, Hundsberger, Thomas, Mergenthaler, Hans-Guenther, Leithaeuser, Malte, Birnbaum, Tobias, Fischer, Lars, Jahnke, Kristoph, Herrlinger, Ulrich, Plasswilm, Ludwig, Naegele, Thomas, Pietsch, Torsten, Bamberg, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Brain Cancer Chemotherapy Clinical trials cytarabine Ifosfamide Lymphoma Methotrexate Neuroimaging Neurotoxicity Radiotherapy Survival
Online-Zugang:	Volltext
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