Transient reverse ventilation-perfusion mismatch in acute pulmonary nitrofurantoin reaction
A 67-yr-old woman with a history of myocardial infarct was admitted to emergency for marked dyspnea, nonproductive cough, nausea and fever. The thorax X-ray revealed a bilateral alveolar and interstitial infiltration pattern with basal accentuation. The cardiac examinations were normal. Technegas ve...
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| Veröffentlicht in: | Annals of nuclear medicine 1997-09, Vol.11 (3), p.271-274 |
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| creator | Başoğlu, T Erkan, L Canbaz, F Bernay, I Onen, T Sahin, M Furtun, F Yalin, T |
| description | A 67-yr-old woman with a history of myocardial infarct was admitted to emergency for marked dyspnea, nonproductive cough, nausea and fever. The thorax X-ray revealed a bilateral alveolar and interstitial infiltration pattern with basal accentuation. The cardiac examinations were normal. Technegas ventilation and Tc-99m-macroaggregated albumin (MAA) perfusion scans were performed to rule out pulmonary embolism. Bilateral multiple ventilation defects with normal perfusion was observed. The patient had been taking nitrofurantoin for four days for a bladder infection. Hypersensitivity to nitrofurantoin was suspected and the drug was discontinued. An antihistaminic and anxiolytic medication was started. The majority of the clinical symptoms disappeared within 24 hours. The control chest X-rays disclosed a marked improvement. Ventilation and perfusion scans obtained 48 hours after nitrofurantoin withdrawal were normal. The drug-related pulmonary reactions should be taken into account in patients on medication. Reversible ventilation defects can be the only lung-scintigraphic finding encountered in acute pulmonary nitrofurantoin reaction. |
| doi_str_mv | 10.1007/BF03164775 |
| format | Article |
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The thorax X-ray revealed a bilateral alveolar and interstitial infiltration pattern with basal accentuation. The cardiac examinations were normal. Technegas ventilation and Tc-99m-macroaggregated albumin (MAA) perfusion scans were performed to rule out pulmonary embolism. Bilateral multiple ventilation defects with normal perfusion was observed. The patient had been taking nitrofurantoin for four days for a bladder infection. Hypersensitivity to nitrofurantoin was suspected and the drug was discontinued. An antihistaminic and anxiolytic medication was started. The majority of the clinical symptoms disappeared within 24 hours. The control chest X-rays disclosed a marked improvement. Ventilation and perfusion scans obtained 48 hours after nitrofurantoin withdrawal were normal. The drug-related pulmonary reactions should be taken into account in patients on medication. Reversible ventilation defects can be the only lung-scintigraphic finding encountered in acute pulmonary nitrofurantoin reaction.</description><identifier>ISSN: 0914-7187</identifier><identifier>EISSN: 1864-6433</identifier><identifier>DOI: 10.1007/BF03164775</identifier><identifier>PMID: 9310179</identifier><language>eng</language><publisher>Japan: Springer Nature B.V</publisher><subject>Aged ; Anti-Infective Agents, Urinary - adverse effects ; Anti-Infective Agents, Urinary - pharmacology ; Female ; Humans ; Lung - diagnostic imaging ; Lung - drug effects ; Nitrofurantoin - adverse effects ; Nitrofurantoin - pharmacology ; Pulmonary Ventilation - drug effects ; Radiography ; Radionuclide Imaging ; Ventilation ; Ventilation-Perfusion Ratio - drug effects ; X-Rays</subject><ispartof>Annals of nuclear medicine, 1997-09, Vol.11 (3), p.271-274</ispartof><rights>Springer-Verlag 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c287t-73de3c62780607d720348964746df23ca50d8099d36f4057f74326c98af728613</citedby><cites>FETCH-LOGICAL-c287t-73de3c62780607d720348964746df23ca50d8099d36f4057f74326c98af728613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9310179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Başoğlu, T</creatorcontrib><creatorcontrib>Erkan, L</creatorcontrib><creatorcontrib>Canbaz, F</creatorcontrib><creatorcontrib>Bernay, I</creatorcontrib><creatorcontrib>Onen, T</creatorcontrib><creatorcontrib>Sahin, M</creatorcontrib><creatorcontrib>Furtun, F</creatorcontrib><creatorcontrib>Yalin, T</creatorcontrib><title>Transient reverse ventilation-perfusion mismatch in acute pulmonary nitrofurantoin reaction</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><description>A 67-yr-old woman with a history of myocardial infarct was admitted to emergency for marked dyspnea, nonproductive cough, nausea and fever. The thorax X-ray revealed a bilateral alveolar and interstitial infiltration pattern with basal accentuation. The cardiac examinations were normal. Technegas ventilation and Tc-99m-macroaggregated albumin (MAA) perfusion scans were performed to rule out pulmonary embolism. Bilateral multiple ventilation defects with normal perfusion was observed. The patient had been taking nitrofurantoin for four days for a bladder infection. Hypersensitivity to nitrofurantoin was suspected and the drug was discontinued. An antihistaminic and anxiolytic medication was started. The majority of the clinical symptoms disappeared within 24 hours. The control chest X-rays disclosed a marked improvement. Ventilation and perfusion scans obtained 48 hours after nitrofurantoin withdrawal were normal. The drug-related pulmonary reactions should be taken into account in patients on medication. Reversible ventilation defects can be the only lung-scintigraphic finding encountered in acute pulmonary nitrofurantoin reaction.</description><subject>Aged</subject><subject>Anti-Infective Agents, Urinary - adverse effects</subject><subject>Anti-Infective Agents, Urinary - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>Lung - diagnostic imaging</subject><subject>Lung - drug effects</subject><subject>Nitrofurantoin - adverse effects</subject><subject>Nitrofurantoin - pharmacology</subject><subject>Pulmonary Ventilation - drug effects</subject><subject>Radiography</subject><subject>Radionuclide Imaging</subject><subject>Ventilation</subject><subject>Ventilation-Perfusion Ratio - drug effects</subject><subject>X-Rays</subject><issn>0914-7187</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kctLAzEQxoMotVYv3oXFg4KwmtfmcdTiCwpe6snDErMJbtlN1mRT8L83pUXBg6eZYX7zMTMfAKcIXiMI-c3dAySIUc6rPTBFgtGSUUL2wRRKREuOBD8ERzGuIMSiEngCJpIgiLicgrdlUC62xo1FMGsToinWuWg7NbbelYMJNsWcFX0bezXqj6J1hdJpNMWQut47Fb4K147B25SVRp_bwSi9mT4GB1Z10Zzs4gy8Ptwv50_l4uXxeX67KDUWfCw5aQzRDHMBGeQNx5BQIfM5lDUWE60q2AgoZUOYpbDillOCmZZCWY4FQ2QGLre6Q_CfycSxzstq03XKGZ9iLStaCYEIzeTFvyRGCAvJSQbP_4Arn4LLV2SmgpRRuYGutpAOPsZgbD2Ets8PqRGsN8bUv8Zk-GynmN570_ygOyfIN5lXh2I</recordid><startdate>19970901</startdate><enddate>19970901</enddate><creator>Başoğlu, T</creator><creator>Erkan, L</creator><creator>Canbaz, F</creator><creator>Bernay, I</creator><creator>Onen, T</creator><creator>Sahin, M</creator><creator>Furtun, F</creator><creator>Yalin, T</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>19970901</creationdate><title>Transient reverse ventilation-perfusion mismatch in acute pulmonary nitrofurantoin reaction</title><author>Başoğlu, T ; Erkan, L ; Canbaz, F ; Bernay, I ; Onen, T ; Sahin, M ; Furtun, F ; Yalin, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-73de3c62780607d720348964746df23ca50d8099d36f4057f74326c98af728613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Aged</topic><topic>Anti-Infective Agents, Urinary - 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The thorax X-ray revealed a bilateral alveolar and interstitial infiltration pattern with basal accentuation. The cardiac examinations were normal. Technegas ventilation and Tc-99m-macroaggregated albumin (MAA) perfusion scans were performed to rule out pulmonary embolism. Bilateral multiple ventilation defects with normal perfusion was observed. The patient had been taking nitrofurantoin for four days for a bladder infection. Hypersensitivity to nitrofurantoin was suspected and the drug was discontinued. An antihistaminic and anxiolytic medication was started. The majority of the clinical symptoms disappeared within 24 hours. The control chest X-rays disclosed a marked improvement. Ventilation and perfusion scans obtained 48 hours after nitrofurantoin withdrawal were normal. The drug-related pulmonary reactions should be taken into account in patients on medication. Reversible ventilation defects can be the only lung-scintigraphic finding encountered in acute pulmonary nitrofurantoin reaction.</abstract><cop>Japan</cop><pub>Springer Nature B.V</pub><pmid>9310179</pmid><doi>10.1007/BF03164775</doi><tpages>4</tpages></addata></record> |
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| ispartof | Annals of nuclear medicine, 1997-09, Vol.11 (3), p.271-274 |
| issn | 0914-7187 1864-6433 |
| language | eng |
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| subjects | Aged Anti-Infective Agents, Urinary - adverse effects Anti-Infective Agents, Urinary - pharmacology Female Humans Lung - diagnostic imaging Lung - drug effects Nitrofurantoin - adverse effects Nitrofurantoin - pharmacology Pulmonary Ventilation - drug effects Radiography Radionuclide Imaging Ventilation Ventilation-Perfusion Ratio - drug effects X-Rays |
| title | Transient reverse ventilation-perfusion mismatch in acute pulmonary nitrofurantoin reaction |
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