Poly (l-lysine) based semi-interpenetrating polymer network as pH-responsive hydrogel for controlled release of a model protein drug streptokinase

With the aim of developing a pH-sensitive controlled drug release system, a poly (L-lysine) (PLL) based cationic semi-interpenetrating polymer network (semi-IPN) has been synthesized. This cationic hydrogel was designed to swell at lower pH and de-swell at higher pH and therefore be applicable for a...

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Veröffentlicht in:	Biotechnology and bioprocess engineering 2001-10, Vol.6 (5), p.326-331
Hauptverfasser:	Park, Yoon-Jeong, Chang, Jin, Chen, Pen-Chung, Yang, Victor Chi-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Cationic polymerization Controlled release Crosslinking Drug delivery Free radical polymerization Hydrogels Interpenetrating networks Interpolymer complexation Ionic interactions L-lysine Lysine pH effects Polyethylene glycol Polymerization Polymers Proteins Sensitivity Streptokinase Swelling Thrombolytic drugs
Online-Zugang:	Volltext
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