Behavioral effects of subchronic inhalation of toluene in adult rats
Abstract Whereas the acute neurobehavioral effects of toluene are robust and well characterized, evidence for persistent effects of repeated exposure to this industrial solvent is less compelling. The present experiment sought to determine whether subchronic inhalation of toluene caused persistent b...
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| Veröffentlicht in: | Neurotoxicology and teratology 2010-11, Vol.32 (6), p.611-619 |
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| creator | Beasley, Tracey E Evansky, Paul A Gilbert, Mary E Bushnell, Philip J |
| description | Abstract Whereas the acute neurobehavioral effects of toluene are robust and well characterized, evidence for persistent effects of repeated exposure to this industrial solvent is less compelling. The present experiment sought to determine whether subchronic inhalation of toluene caused persistent behavioral changes in rats. Adult male Long–Evans rats inhaled toluene vapor (0, 10, 100, or 1000 ppm) for 6 h/day, 5 days/week for 13 weeks and were evaluated on a series of behavioral tests beginning 3 days after the end of exposure. Toluene delayed appetitively-motivated acquisition of a lever-press response, but did not affect motor activity, anxiety-related behavior in the elevated plus maze, trace fear conditioning, acquisition of an appetitively-motivated visual discrimination, or performance of a visual signal detection task. Challenges with acute inhalation of toluene vapor (1200–2400 ppm for 1 h) and injections of quinpirole (0.01–0.03 mg/kg) and raclopride (0.03–0.10 mg/kg) revealed no toluene-induced latent impairments in visual signal detection. These results are consistent with a pattern of subtle and inconsistent long-term effects of daily exposure to toluene vapor, in contrast to robust and reliable effects of acute inhalation of the solvent. |
| doi_str_mv | 10.1016/j.ntt.2010.05.005 |
| format | Article |
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The present experiment sought to determine whether subchronic inhalation of toluene caused persistent behavioral changes in rats. Adult male Long–Evans rats inhaled toluene vapor (0, 10, 100, or 1000 ppm) for 6 h/day, 5 days/week for 13 weeks and were evaluated on a series of behavioral tests beginning 3 days after the end of exposure. Toluene delayed appetitively-motivated acquisition of a lever-press response, but did not affect motor activity, anxiety-related behavior in the elevated plus maze, trace fear conditioning, acquisition of an appetitively-motivated visual discrimination, or performance of a visual signal detection task. Challenges with acute inhalation of toluene vapor (1200–2400 ppm for 1 h) and injections of quinpirole (0.01–0.03 mg/kg) and raclopride (0.03–0.10 mg/kg) revealed no toluene-induced latent impairments in visual signal detection. These results are consistent with a pattern of subtle and inconsistent long-term effects of daily exposure to toluene vapor, in contrast to robust and reliable effects of acute inhalation of the solvent.</description><identifier>ISSN: 0892-0362</identifier><identifier>EISSN: 1872-9738</identifier><identifier>DOI: 10.1016/j.ntt.2010.05.005</identifier><identifier>PMID: 20580818</identifier><identifier>CODEN: NETEEC</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Air Pollutants - toxicity ; Animals ; Behavior, Animal - drug effects ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; Conditioning, Classical - drug effects ; discrimination ; Dopamine Agonists - pharmacology ; Dopamine Antagonists - pharmacology ; Dose-Response Relationship, Drug ; Emergency ; Fear conditioning ; Inhalation ; Inhalation Exposure - adverse effects ; Long-term effects ; Male ; Maze Learning - drug effects ; Medical Education ; Medical sciences ; Motor activity ; Motor Activity - drug effects ; Neurotoxicity ; Organic solvent ; Quinpirole ; Raclopride ; Rats ; Rats, Long-Evans ; Receptors, Dopamine - metabolism ; Signal detection ; Solvents ; Toluene ; Toluene - toxicity ; Toxicology ; Vapors ; Visual discrimination ; Volatilization</subject><ispartof>Neurotoxicology and teratology, 2010-11, Vol.32 (6), p.611-619</ispartof><rights>2010</rights><rights>2015 INIST-CNRS</rights><rights>Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-cbde6d86c07b159b37d093ee426824b3269a0606ba279d62c13aa981832afeb23</citedby><cites>FETCH-LOGICAL-c437t-cbde6d86c07b159b37d093ee426824b3269a0606ba279d62c13aa981832afeb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S089203621000125X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23619688$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20580818$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beasley, Tracey E</creatorcontrib><creatorcontrib>Evansky, Paul A</creatorcontrib><creatorcontrib>Gilbert, Mary E</creatorcontrib><creatorcontrib>Bushnell, Philip J</creatorcontrib><title>Behavioral effects of subchronic inhalation of toluene in adult rats</title><title>Neurotoxicology and teratology</title><addtitle>Neurotoxicol Teratol</addtitle><description>Abstract Whereas the acute neurobehavioral effects of toluene are robust and well characterized, evidence for persistent effects of repeated exposure to this industrial solvent is less compelling. The present experiment sought to determine whether subchronic inhalation of toluene caused persistent behavioral changes in rats. Adult male Long–Evans rats inhaled toluene vapor (0, 10, 100, or 1000 ppm) for 6 h/day, 5 days/week for 13 weeks and were evaluated on a series of behavioral tests beginning 3 days after the end of exposure. Toluene delayed appetitively-motivated acquisition of a lever-press response, but did not affect motor activity, anxiety-related behavior in the elevated plus maze, trace fear conditioning, acquisition of an appetitively-motivated visual discrimination, or performance of a visual signal detection task. Challenges with acute inhalation of toluene vapor (1200–2400 ppm for 1 h) and injections of quinpirole (0.01–0.03 mg/kg) and raclopride (0.03–0.10 mg/kg) revealed no toluene-induced latent impairments in visual signal detection. These results are consistent with a pattern of subtle and inconsistent long-term effects of daily exposure to toluene vapor, in contrast to robust and reliable effects of acute inhalation of the solvent.</description><subject>Air Pollutants - toxicity</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Conditioning, Classical - drug effects</subject><subject>discrimination</subject><subject>Dopamine Agonists - pharmacology</subject><subject>Dopamine Antagonists - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Emergency</subject><subject>Fear conditioning</subject><subject>Inhalation</subject><subject>Inhalation Exposure - adverse effects</subject><subject>Long-term effects</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Medical Education</subject><subject>Medical sciences</subject><subject>Motor activity</subject><subject>Motor Activity - drug effects</subject><subject>Neurotoxicity</subject><subject>Organic solvent</subject><subject>Quinpirole</subject><subject>Raclopride</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Receptors, Dopamine - metabolism</subject><subject>Signal detection</subject><subject>Solvents</subject><subject>Toluene</subject><subject>Toluene - toxicity</subject><subject>Toxicology</subject><subject>Vapors</subject><subject>Visual discrimination</subject><subject>Volatilization</subject><issn>0892-0362</issn><issn>1872-9738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFrFDEYhoModlv9AV5kLuJp1i_JJpMgCLXWKhR6qIK3kMl8w2bNTmqSKfTfm2FXBQ89hSTP-_HxvIS8orCmQOW73XoqZc2g3kGsAcQTsqKqY63uuHpKVqA0a4FLdkJOc94BQCcpPCcnDIQCRdWKfPqIW3vvY7KhwXFEV3ITxybPvdumOHnX-Glrgy0-TstHiWHGCetrY4c5lCbZkl-QZ6MNGV8ezzPy_fPlt4sv7fXN1deL8-vWbXhXWtcPKAclHXQ9Fbrn3QCaI26YVGzTcya1BQmyt6zTg2SOcmt1XZMzO2LP-Bl5e5h7l-KvGXMxe58dhmAnjHM2WmyEEowvJD2QLsWcE47mLvm9TQ-GglncmZ2p7szizoAw1V3NvD5On_s9Dn8Tf2RV4M0RsNnZMCY7OZ__cVxSLdXCvT9wWF3ce0wmO4-Tw8GnKtgM0T-6xof_0i74WoQNP_EB8y7OaaqSDTWZGTC3S8lLx7TWS5n4wX8DYtKgWw</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Beasley, Tracey E</creator><creator>Evansky, Paul A</creator><creator>Gilbert, Mary E</creator><creator>Bushnell, Philip J</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>20101101</creationdate><title>Behavioral effects of subchronic inhalation of toluene in adult rats</title><author>Beasley, Tracey E ; Evansky, Paul A ; Gilbert, Mary E ; Bushnell, Philip J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-cbde6d86c07b159b37d093ee426824b3269a0606ba279d62c13aa981832afeb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Air Pollutants - toxicity</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Conditioning, Classical - drug effects</topic><topic>discrimination</topic><topic>Dopamine Agonists - pharmacology</topic><topic>Dopamine Antagonists - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Emergency</topic><topic>Fear conditioning</topic><topic>Inhalation</topic><topic>Inhalation Exposure - adverse effects</topic><topic>Long-term effects</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Medical Education</topic><topic>Medical sciences</topic><topic>Motor activity</topic><topic>Motor Activity - drug effects</topic><topic>Neurotoxicity</topic><topic>Organic solvent</topic><topic>Quinpirole</topic><topic>Raclopride</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Receptors, Dopamine - metabolism</topic><topic>Signal detection</topic><topic>Solvents</topic><topic>Toluene</topic><topic>Toluene - toxicity</topic><topic>Toxicology</topic><topic>Vapors</topic><topic>Visual discrimination</topic><topic>Volatilization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beasley, Tracey E</creatorcontrib><creatorcontrib>Evansky, Paul A</creatorcontrib><creatorcontrib>Gilbert, Mary E</creatorcontrib><creatorcontrib>Bushnell, Philip J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Neurotoxicology and teratology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beasley, Tracey E</au><au>Evansky, Paul A</au><au>Gilbert, Mary E</au><au>Bushnell, Philip J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral effects of subchronic inhalation of toluene in adult rats</atitle><jtitle>Neurotoxicology and teratology</jtitle><addtitle>Neurotoxicol Teratol</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>32</volume><issue>6</issue><spage>611</spage><epage>619</epage><pages>611-619</pages><issn>0892-0362</issn><eissn>1872-9738</eissn><coden>NETEEC</coden><abstract>Abstract Whereas the acute neurobehavioral effects of toluene are robust and well characterized, evidence for persistent effects of repeated exposure to this industrial solvent is less compelling. The present experiment sought to determine whether subchronic inhalation of toluene caused persistent behavioral changes in rats. Adult male Long–Evans rats inhaled toluene vapor (0, 10, 100, or 1000 ppm) for 6 h/day, 5 days/week for 13 weeks and were evaluated on a series of behavioral tests beginning 3 days after the end of exposure. Toluene delayed appetitively-motivated acquisition of a lever-press response, but did not affect motor activity, anxiety-related behavior in the elevated plus maze, trace fear conditioning, acquisition of an appetitively-motivated visual discrimination, or performance of a visual signal detection task. Challenges with acute inhalation of toluene vapor (1200–2400 ppm for 1 h) and injections of quinpirole (0.01–0.03 mg/kg) and raclopride (0.03–0.10 mg/kg) revealed no toluene-induced latent impairments in visual signal detection. 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| subjects | Air Pollutants - toxicity Animals Behavior, Animal - drug effects Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Conditioning, Classical - drug effects discrimination Dopamine Agonists - pharmacology Dopamine Antagonists - pharmacology Dose-Response Relationship, Drug Emergency Fear conditioning Inhalation Inhalation Exposure - adverse effects Long-term effects Male Maze Learning - drug effects Medical Education Medical sciences Motor activity Motor Activity - drug effects Neurotoxicity Organic solvent Quinpirole Raclopride Rats Rats, Long-Evans Receptors, Dopamine - metabolism Signal detection Solvents Toluene Toluene - toxicity Toxicology Vapors Visual discrimination Volatilization |
| title | Behavioral effects of subchronic inhalation of toluene in adult rats |
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