Evidence that glycogen synthase kinase‐3 isoforms have distinct substrate preference in the brain

J. Neurochem. (2010) 115, 974-983. ABSTRACT: Mammalian glycogen synthase kinase‐3 (GSK3) is generated from two genes, GSK3α and GSK3β, while a splice variant of GSK3β (GSK3β2), containing a 13 amino acid insert, is enriched in neurons. GSK3α and GSK3β deletions generate distinct phenotypes. Here, we...

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Veröffentlicht in:	Journal of neurochemistry 2010-11, Vol.115 (4), p.974-983
Hauptverfasser:	Soutar, Marc P.M, Kim, Woo‐Yang, Williamson, Ritchie, Peggie, Mark, Hastie, Charles James, McLauchlan, Hilary, Snider, William D, Gordon‐Weeks, Phillip R, Sutherland, Calum
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Alternative splicing Alzheimer Disease - enzymology Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Amino Acid Sequence Amino acids Animals ATP Biological and medical sciences Brain Brain - enzymology c-Jun protein c-Myc protein catenin Cell Line Cortex CRMP Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Genetics Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta GSK3 Humans Isoenzymes - genetics Isoenzymes - metabolism Kinases knockout Medical sciences Mice Mice, Knockout Mice, Transgenic Molecular Sequence Data Neurochemistry Neurodegenerative diseases Neurology neuron Neurons Organic mental disorders. Neuropsychology Phosphorylation Phosphorylation - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry splice variant Splicing Substrate preferences Substrate Specificity - genetics Substrates tau Tau protein Transcription factors
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