The effect of trimebutine maleate on gastric emptying in patients with non-ulcer dyspepsia
The study was designed to investigate the effect of trimebutine maleate, a drug used in both hyperkinetic and hypokinetic motility disorders, on gastric emptying in patients with non-ulcer dyspepsia having prolonged gastric emptying rates and to compare the parameters used for the determination of t...
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| Veröffentlicht in: | Annals of nuclear medicine 1999-08, Vol.13 (4), p.231-234 |
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| creator | Aktas, A Caner, B Ozturk, F Bayhan, H Narin, Y Mentes, T |
| description | The study was designed to investigate the effect of trimebutine maleate, a drug used in both hyperkinetic and hypokinetic motility disorders, on gastric emptying in patients with non-ulcer dyspepsia having prolonged gastric emptying rates and to compare the parameters used for the determination of the lag period observed during the emptying of solid foods from the stomach. Gastric emptying was measured by the radionuclide technique. Twenty normal volunteers and 43 patients with non-ulcer dyspepsia participated in the study. Radionuclide imaging was performed by using a solid meal labeled with 99mTc-tin colloid. Of the patients with non-ulcer dyspepsia, 20 had prolonged gastric emptying. They were given three weeks of oral treatment with trimebutine maleate and had their radionuclide gastric emptying study repeated. Treatment with trimebutine maleate resulted in reduction in duration of the lag period and less retention of food at 100 minutes (p < 0.0005). After treatment with trimebutine maleate, no significant difference has been observed in the mean symptom score of patients with prolonged gastric emptying. Among the parameters used for the determination of the lag period, lag period determined by a mathematical equation (TLAG) has been found to be longer than the lag period determined by visual inspection of the images (VLAG) and there was correlation between the two parameters when the lag time was short. |
| doi_str_mv | 10.1007/BF03164897 |
| format | Article |
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Gastric emptying was measured by the radionuclide technique. Twenty normal volunteers and 43 patients with non-ulcer dyspepsia participated in the study. Radionuclide imaging was performed by using a solid meal labeled with 99mTc-tin colloid. Of the patients with non-ulcer dyspepsia, 20 had prolonged gastric emptying. They were given three weeks of oral treatment with trimebutine maleate and had their radionuclide gastric emptying study repeated. Treatment with trimebutine maleate resulted in reduction in duration of the lag period and less retention of food at 100 minutes (p < 0.0005). After treatment with trimebutine maleate, no significant difference has been observed in the mean symptom score of patients with prolonged gastric emptying. Among the parameters used for the determination of the lag period, lag period determined by a mathematical equation (TLAG) has been found to be longer than the lag period determined by visual inspection of the images (VLAG) and there was correlation between the two parameters when the lag time was short.</description><identifier>ISSN: 0914-7187</identifier><identifier>EISSN: 1864-6433</identifier><identifier>DOI: 10.1007/BF03164897</identifier><identifier>PMID: 10510878</identifier><language>eng</language><publisher>Japan: Springer Nature B.V</publisher><subject>Administration, Oral ; Adult ; Colloids ; Digestive system ; Dyspepsia - diagnostic imaging ; Dyspepsia - physiopathology ; Eating ; Female ; Gamma Cameras ; Gastric Emptying - drug effects ; Gastric Emptying - physiology ; Gastrointestinal Agents - administration & dosage ; Gastrointestinal Agents - pharmacology ; Gastrointestinal Agents - therapeutic use ; Humans ; Male ; Middle Aged ; Models, Theoretical ; Reference Values ; Technetium Compounds - administration & dosage ; Technetium Compounds - pharmacokinetics ; Time Factors ; Tin Compounds - administration & dosage ; Tin Compounds - pharmacokinetics ; Tomography, Emission-Computed ; Trimebutine - administration & dosage ; Trimebutine - pharmacology ; Trimebutine - therapeutic use</subject><ispartof>Annals of nuclear medicine, 1999-08, Vol.13 (4), p.231-234</ispartof><rights>Springer-Verlag 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-ae84f605bd8f9585c25ce8addbb9714f26cb60a604c508ec58e84847bc3995ba3</citedby><cites>FETCH-LOGICAL-c402t-ae84f605bd8f9585c25ce8addbb9714f26cb60a604c508ec58e84847bc3995ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10510878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aktas, A</creatorcontrib><creatorcontrib>Caner, B</creatorcontrib><creatorcontrib>Ozturk, F</creatorcontrib><creatorcontrib>Bayhan, H</creatorcontrib><creatorcontrib>Narin, Y</creatorcontrib><creatorcontrib>Mentes, T</creatorcontrib><title>The effect of trimebutine maleate on gastric emptying in patients with non-ulcer dyspepsia</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><description>The study was designed to investigate the effect of trimebutine maleate, a drug used in both hyperkinetic and hypokinetic motility disorders, on gastric emptying in patients with non-ulcer dyspepsia having prolonged gastric emptying rates and to compare the parameters used for the determination of the lag period observed during the emptying of solid foods from the stomach. Gastric emptying was measured by the radionuclide technique. Twenty normal volunteers and 43 patients with non-ulcer dyspepsia participated in the study. Radionuclide imaging was performed by using a solid meal labeled with 99mTc-tin colloid. Of the patients with non-ulcer dyspepsia, 20 had prolonged gastric emptying. They were given three weeks of oral treatment with trimebutine maleate and had their radionuclide gastric emptying study repeated. Treatment with trimebutine maleate resulted in reduction in duration of the lag period and less retention of food at 100 minutes (p < 0.0005). After treatment with trimebutine maleate, no significant difference has been observed in the mean symptom score of patients with prolonged gastric emptying. Among the parameters used for the determination of the lag period, lag period determined by a mathematical equation (TLAG) has been found to be longer than the lag period determined by visual inspection of the images (VLAG) and there was correlation between the two parameters when the lag time was short.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Colloids</subject><subject>Digestive system</subject><subject>Dyspepsia - diagnostic imaging</subject><subject>Dyspepsia - physiopathology</subject><subject>Eating</subject><subject>Female</subject><subject>Gamma Cameras</subject><subject>Gastric Emptying - drug effects</subject><subject>Gastric Emptying - physiology</subject><subject>Gastrointestinal Agents - administration & dosage</subject><subject>Gastrointestinal Agents - pharmacology</subject><subject>Gastrointestinal Agents - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Models, Theoretical</subject><subject>Reference Values</subject><subject>Technetium Compounds - administration & dosage</subject><subject>Technetium Compounds - pharmacokinetics</subject><subject>Time Factors</subject><subject>Tin Compounds - administration & dosage</subject><subject>Tin Compounds - pharmacokinetics</subject><subject>Tomography, Emission-Computed</subject><subject>Trimebutine - administration & dosage</subject><subject>Trimebutine - pharmacology</subject><subject>Trimebutine - therapeutic use</subject><issn>0914-7187</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0cFq3DAQBmARWpJN2kseIIgeEig4HcmSJR2TpdsUFnLZXHoxsjzedbBl15Ip-_ZV2IWGHJrTHOabgZmfkEsGtwxAfbtfQc4KoY06IQumC5EVIs8_kAUYJjLFtDoj5yE8A3AtNT8lZwwkA630gvza7JBi06CLdGhonNoeqzm2HmlvO7QR6eDp1obUcRT7Me5bv6Wtp6ONLfoY6J827qgffDZ3Dida78OIY2jtJ_KxsV3Az8d6QZ5W3zfLh2z9-OPn8m6dOQE8Zha1aAqQVa0bI7V0XDrUtq6ryigmGl64qgBbgHASNDqp04AWqnK5MbKy-QW5Oewdp-H3jCGWfRscdp31OMyhNFKkqxXLk7z-r1SggTOu34WcMW4YsAS_vIHPwzz5dG4yMn05L0xCXw_ITUMIEzblmN5sp33JoHxJsPyXYMJXx41z1WP9ih4iy_8CziaVFg</recordid><startdate>19990801</startdate><enddate>19990801</enddate><creator>Aktas, A</creator><creator>Caner, B</creator><creator>Ozturk, F</creator><creator>Bayhan, H</creator><creator>Narin, Y</creator><creator>Mentes, T</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19990801</creationdate><title>The effect of trimebutine maleate on gastric emptying in patients with non-ulcer dyspepsia</title><author>Aktas, A ; Caner, B ; Ozturk, F ; Bayhan, H ; Narin, Y ; Mentes, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-ae84f605bd8f9585c25ce8addbb9714f26cb60a604c508ec58e84847bc3995ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Colloids</topic><topic>Digestive system</topic><topic>Dyspepsia - 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Academic</collection><jtitle>Annals of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aktas, A</au><au>Caner, B</au><au>Ozturk, F</au><au>Bayhan, H</au><au>Narin, Y</au><au>Mentes, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of trimebutine maleate on gastric emptying in patients with non-ulcer dyspepsia</atitle><jtitle>Annals of nuclear medicine</jtitle><addtitle>Ann Nucl Med</addtitle><date>1999-08-01</date><risdate>1999</risdate><volume>13</volume><issue>4</issue><spage>231</spage><epage>234</epage><pages>231-234</pages><issn>0914-7187</issn><eissn>1864-6433</eissn><abstract>The study was designed to investigate the effect of trimebutine maleate, a drug used in both hyperkinetic and hypokinetic motility disorders, on gastric emptying in patients with non-ulcer dyspepsia having prolonged gastric emptying rates and to compare the parameters used for the determination of the lag period observed during the emptying of solid foods from the stomach. Gastric emptying was measured by the radionuclide technique. Twenty normal volunteers and 43 patients with non-ulcer dyspepsia participated in the study. Radionuclide imaging was performed by using a solid meal labeled with 99mTc-tin colloid. Of the patients with non-ulcer dyspepsia, 20 had prolonged gastric emptying. They were given three weeks of oral treatment with trimebutine maleate and had their radionuclide gastric emptying study repeated. Treatment with trimebutine maleate resulted in reduction in duration of the lag period and less retention of food at 100 minutes (p < 0.0005). After treatment with trimebutine maleate, no significant difference has been observed in the mean symptom score of patients with prolonged gastric emptying. Among the parameters used for the determination of the lag period, lag period determined by a mathematical equation (TLAG) has been found to be longer than the lag period determined by visual inspection of the images (VLAG) and there was correlation between the two parameters when the lag time was short.</abstract><cop>Japan</cop><pub>Springer Nature B.V</pub><pmid>10510878</pmid><doi>10.1007/BF03164897</doi><tpages>4</tpages></addata></record> |
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| ispartof | Annals of nuclear medicine, 1999-08, Vol.13 (4), p.231-234 |
| issn | 0914-7187 1864-6433 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Alma/SFX Local Collection |
| subjects | Administration, Oral Adult Colloids Digestive system Dyspepsia - diagnostic imaging Dyspepsia - physiopathology Eating Female Gamma Cameras Gastric Emptying - drug effects Gastric Emptying - physiology Gastrointestinal Agents - administration & dosage Gastrointestinal Agents - pharmacology Gastrointestinal Agents - therapeutic use Humans Male Middle Aged Models, Theoretical Reference Values Technetium Compounds - administration & dosage Technetium Compounds - pharmacokinetics Time Factors Tin Compounds - administration & dosage Tin Compounds - pharmacokinetics Tomography, Emission-Computed Trimebutine - administration & dosage Trimebutine - pharmacology Trimebutine - therapeutic use |
| title | The effect of trimebutine maleate on gastric emptying in patients with non-ulcer dyspepsia |
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