Effect of posaconazole on the pharmacokinetics of fosamprenavir and vice versa in healthy volunteers

Objectives To manage the interaction between fosamprenavir/ritonavir and posaconazole, we hypothesized that ritonavir can be replaced by posaconazole as an alternative booster of fosamprenavir with no significant influence on posaconazole pharmacokinetics. Methods This was an open-label, randomized,...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2010-10, Vol.65 (10), p.2188-2194
Hauptverfasser:	Brüggemann, Roger J. M., van Luin, Matthijs, Colbers, Engelina P. H., van den Dungen, Myrthe W., Pharo, Cristina, Schouwenberg, Bas J. J. W., Burger, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Anti-HIV Agents - administration & dosage Anti-HIV Agents - pharmacokinetics Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Agents - administration & dosage Antifungal Agents - pharmacokinetics Antiretroviral drugs azole antifungal drugs Biological and medical sciences Carbamates - administration & dosage Carbamates - pharmacokinetics Clinical trials Cross-Over Studies Drug Interactions drug–drug interaction Effects Female Healthy Volunteers Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Male Medical sciences Middle Aged Organophosphates - administration & dosage Organophosphates - pharmacokinetics pharmacokinetic Pharmacology Pharmacology. Drug treatments Sulfonamides - administration & dosage Sulfonamides - pharmacokinetics Triazoles - administration & dosage Triazoles - pharmacokinetics Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Volunteers Young Adult
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