Cortical spreading depression modifies components of the inflammatory cascade
As more information becomes available regarding the role of inflammation following stroke, it is apparent that some inflammatory mediators are detrimental and others are beneficial to the progression of ischemic injury. Cortical spreading depression (CSD) is known to impart some degree of ischemic t...
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| Veröffentlicht in: | Molecular neurobiology 2005-08, Vol.32 (1), p.51-57 |
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| creator | Thompson, Charlie S Hakim, Antoine M |
| description | As more information becomes available regarding the role of inflammation following stroke, it is apparent that some inflammatory mediators are detrimental and others are beneficial to the progression of ischemic injury. Cortical spreading depression (CSD) is known to impart some degree of ischemic tolerance to the brain and to influence the expression of many genes. Many of the genes whose expression is altered by CSD are associated with inflammation, and it appears likely that modulation of the inflammatory response to ischemia by CSD contributes to ischemic tolerance. Understanding which inflammatory processes are influenced by CSD may lead to the identification of novel targets in the effort to develop an acute treatment for stroke. |
| doi_str_mv | 10.1385/mn:32:1:051 |
| format | Article |
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Understanding which inflammatory processes are influenced by CSD may lead to the identification of novel targets in the effort to develop an acute treatment for stroke.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1385/mn:32:1:051</identifier><identifier>PMID: 16077183</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Cortical Spreading Depression - genetics ; Cortical Spreading Depression - physiology ; Inflammation - genetics ; Inflammation - physiopathology ; Ischemia - physiopathology</subject><ispartof>Molecular neurobiology, 2005-08, Vol.32 (1), p.51-57</ispartof><rights>Humana Press Inc. 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-2a726c6a4dab6eeb606711876f82e9aa449db32a01f1d5075d2fede487f3ee113</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16077183$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thompson, Charlie S</creatorcontrib><creatorcontrib>Hakim, Antoine M</creatorcontrib><title>Cortical spreading depression modifies components of the inflammatory cascade</title><title>Molecular neurobiology</title><addtitle>Mol Neurobiol</addtitle><description>As more information becomes available regarding the role of inflammation following stroke, it is apparent that some inflammatory mediators are detrimental and others are beneficial to the progression of ischemic injury. 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| ispartof | Molecular neurobiology, 2005-08, Vol.32 (1), p.51-57 |
| issn | 0893-7648 0893-7648 1559-1182 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Cortical Spreading Depression - genetics Cortical Spreading Depression - physiology Inflammation - genetics Inflammation - physiopathology Ischemia - physiopathology |
| title | Cortical spreading depression modifies components of the inflammatory cascade |
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