Proliferative, apoptotic and angiogenic potentials in jaws and long bones osteosarcomas: a comparative immunohistochemical study

J Oral Pathol Med (2010) 39: 681–686 Background:  Osteosarcomas (OS) of the jaws are uncommon lesions that represent less than 10% of all skeletal OS. It has a behavioral pattern which is less aggressive than their long bones counterparts. This study performed an immunohistochemical comparison betwe...

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Veröffentlicht in:Journal of oral pathology & medicine 2010-10, Vol.39 (9), p.681-686
Hauptverfasser: Jawad, Salam N., Abdullah, Bashar H.
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Abdullah, Bashar H.
description J Oral Pathol Med (2010) 39: 681–686 Background:  Osteosarcomas (OS) of the jaws are uncommon lesions that represent less than 10% of all skeletal OS. It has a behavioral pattern which is less aggressive than their long bones counterparts. This study performed an immunohistochemical comparison between jaws and long bones OS. Methods:  The study involved 15 jaws and 15 long bones OS tissue samples for the period from 1986 to 2005. Age, sex, histologic subtypes and grades were recognized. The samples were immunohistochemically stained with monoclonal antibodies to Ki‐67, P53 and vascular endothelial growth factor (VEGF). Results:  The mean age of the patients with jaw OS was a decade higher than that of long bones OS. A slight male predominance in jaw OS was found (1.14:1), which was more pronounced in long bones OS (2:1). The chondroblastic subtype was the predominant in jaws (66.66%), whereas (60%) of long bones OS were of osteoblastic subtype. The Ki‐67 labeling index and the VEGF expression were significantly higher in long bones as compared with jaws OS, whereas there was no significant difference regarding the P53 expression between jaws and long bones OS. Conclusions:  Jaws and long bones OS bear a comparable cell cycle dysregulation when quantified with P53 immunostaining, whereas the long bones OS have a higher proliferative and angiogenic capacity than their jaw counterparts when evaluated with Ki‐67 and VEGF immunoexpressions respectively.
doi_str_mv 10.1111/j.1600-0714.2010.00923.x
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It has a behavioral pattern which is less aggressive than their long bones counterparts. This study performed an immunohistochemical comparison between jaws and long bones OS. Methods:  The study involved 15 jaws and 15 long bones OS tissue samples for the period from 1986 to 2005. Age, sex, histologic subtypes and grades were recognized. The samples were immunohistochemically stained with monoclonal antibodies to Ki‐67, P53 and vascular endothelial growth factor (VEGF). Results:  The mean age of the patients with jaw OS was a decade higher than that of long bones OS. A slight male predominance in jaw OS was found (1.14:1), which was more pronounced in long bones OS (2:1). The chondroblastic subtype was the predominant in jaws (66.66%), whereas (60%) of long bones OS were of osteoblastic subtype. The Ki‐67 labeling index and the VEGF expression were significantly higher in long bones as compared with jaws OS, whereas there was no significant difference regarding the P53 expression between jaws and long bones OS. Conclusions:  Jaws and long bones OS bear a comparable cell cycle dysregulation when quantified with P53 immunostaining, whereas the long bones OS have a higher proliferative and angiogenic capacity than their jaw counterparts when evaluated with Ki‐67 and VEGF immunoexpressions respectively.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/j.1600-0714.2010.00923.x</identifier><identifier>PMID: 20701666</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Age ; Analysis of Variance ; Angiogenesis ; Apoptosis ; Biological and medical sciences ; Bone (long) ; Bone Neoplasms - metabolism ; Bone Neoplasms - pathology ; Cell cycle ; Cell Proliferation ; Chi-Square Distribution ; Chondrocytes - pathology ; Dentistry ; Diseases of the osteoarticular system ; Female ; Fibroblasts - pathology ; Humans ; Immunohistochemistry ; Jaw ; Jaw Neoplasms - metabolism ; Jaw Neoplasms - pathology ; jaw osteosarcoma ; Ki-67 ; Ki-67 Antigen - analysis ; Male ; Medical sciences ; Monoclonal antibodies ; Neovascularization, Pathologic ; Osteoblasts ; Osteoblasts - pathology ; Osteosarcoma ; Osteosarcoma - metabolism ; Osteosarcoma - pathology ; Otorhinolaryngology. 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It has a behavioral pattern which is less aggressive than their long bones counterparts. This study performed an immunohistochemical comparison between jaws and long bones OS. Methods:  The study involved 15 jaws and 15 long bones OS tissue samples for the period from 1986 to 2005. Age, sex, histologic subtypes and grades were recognized. The samples were immunohistochemically stained with monoclonal antibodies to Ki‐67, P53 and vascular endothelial growth factor (VEGF). Results:  The mean age of the patients with jaw OS was a decade higher than that of long bones OS. A slight male predominance in jaw OS was found (1.14:1), which was more pronounced in long bones OS (2:1). The chondroblastic subtype was the predominant in jaws (66.66%), whereas (60%) of long bones OS were of osteoblastic subtype. The Ki‐67 labeling index and the VEGF expression were significantly higher in long bones as compared with jaws OS, whereas there was no significant difference regarding the P53 expression between jaws and long bones OS. Conclusions:  Jaws and long bones OS bear a comparable cell cycle dysregulation when quantified with P53 immunostaining, whereas the long bones OS have a higher proliferative and angiogenic capacity than their jaw counterparts when evaluated with Ki‐67 and VEGF immunoexpressions respectively.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Analysis of Variance</subject><subject>Angiogenesis</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Bone (long)</subject><subject>Bone Neoplasms - metabolism</subject><subject>Bone Neoplasms - pathology</subject><subject>Cell cycle</subject><subject>Cell Proliferation</subject><subject>Chi-Square Distribution</subject><subject>Chondrocytes - pathology</subject><subject>Dentistry</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Fibroblasts - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Jaw</subject><subject>Jaw Neoplasms - metabolism</subject><subject>Jaw Neoplasms - pathology</subject><subject>jaw osteosarcoma</subject><subject>Ki-67</subject><subject>Ki-67 Antigen - analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Monoclonal antibodies</subject><subject>Neovascularization, Pathologic</subject><subject>Osteoblasts</subject><subject>Osteoblasts - pathology</subject><subject>Osteosarcoma</subject><subject>Osteosarcoma - metabolism</subject><subject>Osteosarcoma - pathology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>P53</subject><subject>p53 protein</subject><subject>Retrospective Studies</subject><subject>Sex</subject><subject>Statistics, Nonparametric</subject><subject>Tumor Suppressor Protein p53 - biosynthesis</subject><subject>Tumors of striated muscle and skeleton</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - biosynthesis</subject><subject>VEGF</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv2yAUx9G0aU27fYWJy7TLnD3AGHvaZarWplPU9rApR4QxTsls4xq8Jrd-9OImy45FQjze-_2f4P0RwgTmJK4vmznJABIQJJ1TiFmAgrL59hWaHQuv0QwKSBPKCT1Bp95vAIhgKXmLTigIIFmWzdDj7eAaW5tBBfvXfMaqd31wwWqsuirutXVr08Vr74LpglWNx7bDG_Xgn4nGdWtcus547HwwzqtBu1b5r1jhGPRq3xjbth07d2d9cPrOtFarBvswVrt36E0dm5r3h_MM_b748et8kSxvLq_Ovy8TnZKcJWVNhVBZnqclhbIoSsEZZ7rgFcuzKZUZTSnThlHORFXmpapFVQgKGc95pM7Qp33ffnD3o_FBttZr0zSqM270suApF7kA-iIpeJwcYzmP5IcDOZatqWQ_2FYNO_lvvBH4eACUjz-uB9Vp6_9zjLH4PIjctz33YBuzO9YJyMluuZGTq3JyVU52y2e75Vb-vLmNQZQne3kcr9ke5Wr4IzPBBJer60u5oOxiAcuVXLEnySSt0w</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Jawad, Salam N.</creator><creator>Abdullah, Bashar H.</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>201010</creationdate><title>Proliferative, apoptotic and angiogenic potentials in jaws and long bones osteosarcomas: a comparative immunohistochemical study</title><author>Jawad, Salam N. ; Abdullah, Bashar H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4183-bf277a6884b20b99b75353c95d386b20b6ec223ce32537db8baf7d972065855d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Analysis of Variance</topic><topic>Angiogenesis</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Bone (long)</topic><topic>Bone Neoplasms - metabolism</topic><topic>Bone Neoplasms - pathology</topic><topic>Cell cycle</topic><topic>Cell Proliferation</topic><topic>Chi-Square Distribution</topic><topic>Chondrocytes - pathology</topic><topic>Dentistry</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Fibroblasts - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Jaw</topic><topic>Jaw Neoplasms - metabolism</topic><topic>Jaw Neoplasms - pathology</topic><topic>jaw osteosarcoma</topic><topic>Ki-67</topic><topic>Ki-67 Antigen - analysis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Monoclonal antibodies</topic><topic>Neovascularization, Pathologic</topic><topic>Osteoblasts</topic><topic>Osteoblasts - pathology</topic><topic>Osteosarcoma</topic><topic>Osteosarcoma - metabolism</topic><topic>Osteosarcoma - pathology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>P53</topic><topic>p53 protein</topic><topic>Retrospective Studies</topic><topic>Sex</topic><topic>Statistics, Nonparametric</topic><topic>Tumor Suppressor Protein p53 - biosynthesis</topic><topic>Tumors of striated muscle and skeleton</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - biosynthesis</topic><topic>VEGF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jawad, Salam N.</creatorcontrib><creatorcontrib>Abdullah, Bashar H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><jtitle>Journal of oral pathology &amp; medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jawad, Salam N.</au><au>Abdullah, Bashar H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proliferative, apoptotic and angiogenic potentials in jaws and long bones osteosarcomas: a comparative immunohistochemical study</atitle><jtitle>Journal of oral pathology &amp; medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2010-10</date><risdate>2010</risdate><volume>39</volume><issue>9</issue><spage>681</spage><epage>686</epage><pages>681-686</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>J Oral Pathol Med (2010) 39: 681–686 Background:  Osteosarcomas (OS) of the jaws are uncommon lesions that represent less than 10% of all skeletal OS. It has a behavioral pattern which is less aggressive than their long bones counterparts. This study performed an immunohistochemical comparison between jaws and long bones OS. Methods:  The study involved 15 jaws and 15 long bones OS tissue samples for the period from 1986 to 2005. Age, sex, histologic subtypes and grades were recognized. The samples were immunohistochemically stained with monoclonal antibodies to Ki‐67, P53 and vascular endothelial growth factor (VEGF). Results:  The mean age of the patients with jaw OS was a decade higher than that of long bones OS. A slight male predominance in jaw OS was found (1.14:1), which was more pronounced in long bones OS (2:1). The chondroblastic subtype was the predominant in jaws (66.66%), whereas (60%) of long bones OS were of osteoblastic subtype. The Ki‐67 labeling index and the VEGF expression were significantly higher in long bones as compared with jaws OS, whereas there was no significant difference regarding the P53 expression between jaws and long bones OS. Conclusions:  Jaws and long bones OS bear a comparable cell cycle dysregulation when quantified with P53 immunostaining, whereas the long bones OS have a higher proliferative and angiogenic capacity than their jaw counterparts when evaluated with Ki‐67 and VEGF immunoexpressions respectively.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20701666</pmid><doi>10.1111/j.1600-0714.2010.00923.x</doi><tpages>6</tpages></addata></record>
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subjects Adolescent
Adult
Age
Analysis of Variance
Angiogenesis
Apoptosis
Biological and medical sciences
Bone (long)
Bone Neoplasms - metabolism
Bone Neoplasms - pathology
Cell cycle
Cell Proliferation
Chi-Square Distribution
Chondrocytes - pathology
Dentistry
Diseases of the osteoarticular system
Female
Fibroblasts - pathology
Humans
Immunohistochemistry
Jaw
Jaw Neoplasms - metabolism
Jaw Neoplasms - pathology
jaw osteosarcoma
Ki-67
Ki-67 Antigen - analysis
Male
Medical sciences
Monoclonal antibodies
Neovascularization, Pathologic
Osteoblasts
Osteoblasts - pathology
Osteosarcoma
Osteosarcoma - metabolism
Osteosarcoma - pathology
Otorhinolaryngology. Stomatology
P53
p53 protein
Retrospective Studies
Sex
Statistics, Nonparametric
Tumor Suppressor Protein p53 - biosynthesis
Tumors of striated muscle and skeleton
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - biosynthesis
VEGF
title Proliferative, apoptotic and angiogenic potentials in jaws and long bones osteosarcomas: a comparative immunohistochemical study
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