Proliferative, apoptotic and angiogenic potentials in jaws and long bones osteosarcomas: a comparative immunohistochemical study
J Oral Pathol Med (2010) 39: 681–686 Background: Osteosarcomas (OS) of the jaws are uncommon lesions that represent less than 10% of all skeletal OS. It has a behavioral pattern which is less aggressive than their long bones counterparts. This study performed an immunohistochemical comparison betwe...
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description | J Oral Pathol Med (2010) 39: 681–686
Background: Osteosarcomas (OS) of the jaws are uncommon lesions that represent less than 10% of all skeletal OS. It has a behavioral pattern which is less aggressive than their long bones counterparts. This study performed an immunohistochemical comparison between jaws and long bones OS.
Methods: The study involved 15 jaws and 15 long bones OS tissue samples for the period from 1986 to 2005. Age, sex, histologic subtypes and grades were recognized. The samples were immunohistochemically stained with monoclonal antibodies to Ki‐67, P53 and vascular endothelial growth factor (VEGF).
Results: The mean age of the patients with jaw OS was a decade higher than that of long bones OS. A slight male predominance in jaw OS was found (1.14:1), which was more pronounced in long bones OS (2:1). The chondroblastic subtype was the predominant in jaws (66.66%), whereas (60%) of long bones OS were of osteoblastic subtype. The Ki‐67 labeling index and the VEGF expression were significantly higher in long bones as compared with jaws OS, whereas there was no significant difference regarding the P53 expression between jaws and long bones OS.
Conclusions: Jaws and long bones OS bear a comparable cell cycle dysregulation when quantified with P53 immunostaining, whereas the long bones OS have a higher proliferative and angiogenic capacity than their jaw counterparts when evaluated with Ki‐67 and VEGF immunoexpressions respectively. |
doi_str_mv | 10.1111/j.1600-0714.2010.00923.x |
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Background: Osteosarcomas (OS) of the jaws are uncommon lesions that represent less than 10% of all skeletal OS. It has a behavioral pattern which is less aggressive than their long bones counterparts. This study performed an immunohistochemical comparison between jaws and long bones OS.
Methods: The study involved 15 jaws and 15 long bones OS tissue samples for the period from 1986 to 2005. Age, sex, histologic subtypes and grades were recognized. The samples were immunohistochemically stained with monoclonal antibodies to Ki‐67, P53 and vascular endothelial growth factor (VEGF).
Results: The mean age of the patients with jaw OS was a decade higher than that of long bones OS. A slight male predominance in jaw OS was found (1.14:1), which was more pronounced in long bones OS (2:1). The chondroblastic subtype was the predominant in jaws (66.66%), whereas (60%) of long bones OS were of osteoblastic subtype. The Ki‐67 labeling index and the VEGF expression were significantly higher in long bones as compared with jaws OS, whereas there was no significant difference regarding the P53 expression between jaws and long bones OS.
Conclusions: Jaws and long bones OS bear a comparable cell cycle dysregulation when quantified with P53 immunostaining, whereas the long bones OS have a higher proliferative and angiogenic capacity than their jaw counterparts when evaluated with Ki‐67 and VEGF immunoexpressions respectively.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/j.1600-0714.2010.00923.x</identifier><identifier>PMID: 20701666</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Age ; Analysis of Variance ; Angiogenesis ; Apoptosis ; Biological and medical sciences ; Bone (long) ; Bone Neoplasms - metabolism ; Bone Neoplasms - pathology ; Cell cycle ; Cell Proliferation ; Chi-Square Distribution ; Chondrocytes - pathology ; Dentistry ; Diseases of the osteoarticular system ; Female ; Fibroblasts - pathology ; Humans ; Immunohistochemistry ; Jaw ; Jaw Neoplasms - metabolism ; Jaw Neoplasms - pathology ; jaw osteosarcoma ; Ki-67 ; Ki-67 Antigen - analysis ; Male ; Medical sciences ; Monoclonal antibodies ; Neovascularization, Pathologic ; Osteoblasts ; Osteoblasts - pathology ; Osteosarcoma ; Osteosarcoma - metabolism ; Osteosarcoma - pathology ; Otorhinolaryngology. Stomatology ; P53 ; p53 protein ; Retrospective Studies ; Sex ; Statistics, Nonparametric ; Tumor Suppressor Protein p53 - biosynthesis ; Tumors of striated muscle and skeleton ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - biosynthesis ; VEGF</subject><ispartof>Journal of oral pathology & medicine, 2010-10, Vol.39 (9), p.681-686</ispartof><rights>2010 The Authors. Journal of Oral Pathology & Medicine © 2010 John Wiley & Sons A/S</rights><rights>2015 INIST-CNRS</rights><rights>2010 The Authors. Journal of Oral Pathology & Medicine © 2010 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4183-bf277a6884b20b99b75353c95d386b20b6ec223ce32537db8baf7d972065855d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0714.2010.00923.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0714.2010.00923.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23336580$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20701666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jawad, Salam N.</creatorcontrib><creatorcontrib>Abdullah, Bashar H.</creatorcontrib><title>Proliferative, apoptotic and angiogenic potentials in jaws and long bones osteosarcomas: a comparative immunohistochemical study</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>J Oral Pathol Med (2010) 39: 681–686
Background: Osteosarcomas (OS) of the jaws are uncommon lesions that represent less than 10% of all skeletal OS. It has a behavioral pattern which is less aggressive than their long bones counterparts. This study performed an immunohistochemical comparison between jaws and long bones OS.
Methods: The study involved 15 jaws and 15 long bones OS tissue samples for the period from 1986 to 2005. Age, sex, histologic subtypes and grades were recognized. The samples were immunohistochemically stained with monoclonal antibodies to Ki‐67, P53 and vascular endothelial growth factor (VEGF).
Results: The mean age of the patients with jaw OS was a decade higher than that of long bones OS. A slight male predominance in jaw OS was found (1.14:1), which was more pronounced in long bones OS (2:1). The chondroblastic subtype was the predominant in jaws (66.66%), whereas (60%) of long bones OS were of osteoblastic subtype. The Ki‐67 labeling index and the VEGF expression were significantly higher in long bones as compared with jaws OS, whereas there was no significant difference regarding the P53 expression between jaws and long bones OS.
Conclusions: Jaws and long bones OS bear a comparable cell cycle dysregulation when quantified with P53 immunostaining, whereas the long bones OS have a higher proliferative and angiogenic capacity than their jaw counterparts when evaluated with Ki‐67 and VEGF immunoexpressions respectively.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Analysis of Variance</subject><subject>Angiogenesis</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Bone (long)</subject><subject>Bone Neoplasms - metabolism</subject><subject>Bone Neoplasms - pathology</subject><subject>Cell cycle</subject><subject>Cell Proliferation</subject><subject>Chi-Square Distribution</subject><subject>Chondrocytes - pathology</subject><subject>Dentistry</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Fibroblasts - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Jaw</subject><subject>Jaw Neoplasms - metabolism</subject><subject>Jaw Neoplasms - pathology</subject><subject>jaw osteosarcoma</subject><subject>Ki-67</subject><subject>Ki-67 Antigen - analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Monoclonal antibodies</subject><subject>Neovascularization, Pathologic</subject><subject>Osteoblasts</subject><subject>Osteoblasts - pathology</subject><subject>Osteosarcoma</subject><subject>Osteosarcoma - metabolism</subject><subject>Osteosarcoma - pathology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>P53</subject><subject>p53 protein</subject><subject>Retrospective Studies</subject><subject>Sex</subject><subject>Statistics, Nonparametric</subject><subject>Tumor Suppressor Protein p53 - biosynthesis</subject><subject>Tumors of striated muscle and skeleton</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - biosynthesis</subject><subject>VEGF</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv2yAUx9G0aU27fYWJy7TLnD3AGHvaZarWplPU9rApR4QxTsls4xq8Jrd-9OImy45FQjze-_2f4P0RwgTmJK4vmznJABIQJJ1TiFmAgrL59hWaHQuv0QwKSBPKCT1Bp95vAIhgKXmLTigIIFmWzdDj7eAaW5tBBfvXfMaqd31wwWqsuirutXVr08Vr74LpglWNx7bDG_Xgn4nGdWtcus547HwwzqtBu1b5r1jhGPRq3xjbth07d2d9cPrOtFarBvswVrt36E0dm5r3h_MM_b748et8kSxvLq_Ovy8TnZKcJWVNhVBZnqclhbIoSsEZZ7rgFcuzKZUZTSnThlHORFXmpapFVQgKGc95pM7Qp33ffnD3o_FBttZr0zSqM270suApF7kA-iIpeJwcYzmP5IcDOZatqWQ_2FYNO_lvvBH4eACUjz-uB9Vp6_9zjLH4PIjctz33YBuzO9YJyMluuZGTq3JyVU52y2e75Vb-vLmNQZQne3kcr9ke5Wr4IzPBBJer60u5oOxiAcuVXLEnySSt0w</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Jawad, Salam N.</creator><creator>Abdullah, Bashar H.</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>201010</creationdate><title>Proliferative, apoptotic and angiogenic potentials in jaws and long bones osteosarcomas: a comparative immunohistochemical study</title><author>Jawad, Salam N. ; Abdullah, Bashar H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4183-bf277a6884b20b99b75353c95d386b20b6ec223ce32537db8baf7d972065855d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Analysis of Variance</topic><topic>Angiogenesis</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Bone (long)</topic><topic>Bone Neoplasms - metabolism</topic><topic>Bone Neoplasms - pathology</topic><topic>Cell cycle</topic><topic>Cell Proliferation</topic><topic>Chi-Square Distribution</topic><topic>Chondrocytes - pathology</topic><topic>Dentistry</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Fibroblasts - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Jaw</topic><topic>Jaw Neoplasms - metabolism</topic><topic>Jaw Neoplasms - pathology</topic><topic>jaw osteosarcoma</topic><topic>Ki-67</topic><topic>Ki-67 Antigen - analysis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Monoclonal antibodies</topic><topic>Neovascularization, Pathologic</topic><topic>Osteoblasts</topic><topic>Osteoblasts - pathology</topic><topic>Osteosarcoma</topic><topic>Osteosarcoma - metabolism</topic><topic>Osteosarcoma - pathology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>P53</topic><topic>p53 protein</topic><topic>Retrospective Studies</topic><topic>Sex</topic><topic>Statistics, Nonparametric</topic><topic>Tumor Suppressor Protein p53 - biosynthesis</topic><topic>Tumors of striated muscle and skeleton</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - biosynthesis</topic><topic>VEGF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jawad, Salam N.</creatorcontrib><creatorcontrib>Abdullah, Bashar H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jawad, Salam N.</au><au>Abdullah, Bashar H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proliferative, apoptotic and angiogenic potentials in jaws and long bones osteosarcomas: a comparative immunohistochemical study</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2010-10</date><risdate>2010</risdate><volume>39</volume><issue>9</issue><spage>681</spage><epage>686</epage><pages>681-686</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>J Oral Pathol Med (2010) 39: 681–686
Background: Osteosarcomas (OS) of the jaws are uncommon lesions that represent less than 10% of all skeletal OS. It has a behavioral pattern which is less aggressive than their long bones counterparts. This study performed an immunohistochemical comparison between jaws and long bones OS.
Methods: The study involved 15 jaws and 15 long bones OS tissue samples for the period from 1986 to 2005. Age, sex, histologic subtypes and grades were recognized. The samples were immunohistochemically stained with monoclonal antibodies to Ki‐67, P53 and vascular endothelial growth factor (VEGF).
Results: The mean age of the patients with jaw OS was a decade higher than that of long bones OS. A slight male predominance in jaw OS was found (1.14:1), which was more pronounced in long bones OS (2:1). The chondroblastic subtype was the predominant in jaws (66.66%), whereas (60%) of long bones OS were of osteoblastic subtype. The Ki‐67 labeling index and the VEGF expression were significantly higher in long bones as compared with jaws OS, whereas there was no significant difference regarding the P53 expression between jaws and long bones OS.
Conclusions: Jaws and long bones OS bear a comparable cell cycle dysregulation when quantified with P53 immunostaining, whereas the long bones OS have a higher proliferative and angiogenic capacity than their jaw counterparts when evaluated with Ki‐67 and VEGF immunoexpressions respectively.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20701666</pmid><doi>10.1111/j.1600-0714.2010.00923.x</doi><tpages>6</tpages></addata></record> |
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subjects | Adolescent Adult Age Analysis of Variance Angiogenesis Apoptosis Biological and medical sciences Bone (long) Bone Neoplasms - metabolism Bone Neoplasms - pathology Cell cycle Cell Proliferation Chi-Square Distribution Chondrocytes - pathology Dentistry Diseases of the osteoarticular system Female Fibroblasts - pathology Humans Immunohistochemistry Jaw Jaw Neoplasms - metabolism Jaw Neoplasms - pathology jaw osteosarcoma Ki-67 Ki-67 Antigen - analysis Male Medical sciences Monoclonal antibodies Neovascularization, Pathologic Osteoblasts Osteoblasts - pathology Osteosarcoma Osteosarcoma - metabolism Osteosarcoma - pathology Otorhinolaryngology. Stomatology P53 p53 protein Retrospective Studies Sex Statistics, Nonparametric Tumor Suppressor Protein p53 - biosynthesis Tumors of striated muscle and skeleton Vascular endothelial growth factor Vascular Endothelial Growth Factor A - biosynthesis VEGF |
title | Proliferative, apoptotic and angiogenic potentials in jaws and long bones osteosarcomas: a comparative immunohistochemical study |
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