The production ratios of AICDe51 and Ab42 by intramembrane proteolysis of bAPP do not always change in parallel

AbstractBackground: During intramembrane proteolysis of b-amyloid protein precursor (bAPP) by presenilin (PS)/g-secretase, e-cleavages at the membrane-cytoplasmic border precede g-cleavages at the middle of the transmembrane domain. Generation ratios of Ab42, a critical molecule for Alzheimer's...

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Veröffentlicht in:	Psychogeriatrics 2010-09, Vol.10 (3), p.117-123
Hauptverfasser:	MORI, Kohji, OKOCHI, Masayasu, TAGAMI, Shinji, NAKAYAMA, Taisuke, YANAGIDA, Kanta, KODAMA, Takashi S, TATSUMI, Shin-ichi, FUJII, Kana, TANIMUKAI, Hitoshi, HASHIMOTO, Ryota, MORIHARA, Takashi, TANAKA, Toshihisa, KUDO, Takashi, FUNAMOTO, Satoru, IHARA, Yasuo, TAKEDA, Masatoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid precursor protein b-Amyloid Neurodegenerative diseases Pharmaceuticals Presenilin Proteolysis Secretase Transmembrane domains
Online-Zugang:	Volltext
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