Association Between Polymorphisms of the Dopamine Receptor D2 and Catechol-o-Methyl Transferase Genes and Cognitive Function

The dopaminergic neurotransmitter system of the brain is involved in working memory and other cognitive functions. Studies suggest an important role for dopamine synthesis and uptake in modulation of human cognitive processes. We studied the association between polymorphisms in the catechol - o - me...

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Veröffentlicht in:	Behavior genetics 2010-09, Vol.40 (5), p.630-638
Hauptverfasser:	Bolton, Jennifer L., Marioni, Riccardo E., Deary, Ian J., Harris, Sarah E., Stewart, Marlene C., Murray, Gordon D., Fowkes, F. Gerry R., Price, Jackie F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aged, 80 and over Atherosclerosis Behavioral Science and Psychology Brain Catechol O-Methyltransferase - genetics Clinical Psychology Cognition & reasoning Cognition - physiology Cognitive abilities Cognitive ability Cognitive functioning Cognitive processes Dopamine Dopamine - metabolism Enzymes Female Genes Genotype Health care Health Psychology Humans Male Memory Middle Aged Neuropsychological Tests Original Research Polymorphism, Single Nucleotide Psychology Public Health Receptors, Dopamine D2 - genetics Scotland
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container_end_page	638
container_issue	5
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container_title	Behavior genetics
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creator	Bolton, Jennifer L. Marioni, Riccardo E. Deary, Ian J. Harris, Sarah E. Stewart, Marlene C. Murray, Gordon D. Fowkes, F. Gerry R. Price, Jackie F.
description	The dopaminergic neurotransmitter system of the brain is involved in working memory and other cognitive functions. Studies suggest an important role for dopamine synthesis and uptake in modulation of human cognitive processes. We studied the association between polymorphisms in the catechol - o - methyl transferase ( COMT ) and dopamine receptor D2 ( DRD2 ) genes and general cognitive ability in a secondary analysis of 2091 men and women, aged 55–80 years living in Scotland. General cognitive ability ‘g’ was derived from five cognitive tests of different domains. COMT was not associated with cognitive ability in this population. The DRD2 C:C genotype of rs6277 was associated with decreased general cognitive ability ‘g’ ( p = 0.003), and DRD2 rs1800497 heterozygotes had lowest mean general cognitive ability ‘g’ ( p = 0.007). There was an indication of a potential interaction between the DRD2 SNPs.
doi_str_mv	10.1007/s10519-010-9372-y
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Gerry R.</creatorcontrib><creatorcontrib>Price, Jackie F.</creatorcontrib><title>Association Between Polymorphisms of the Dopamine Receptor D2 and Catechol-o-Methyl Transferase Genes and Cognitive Function</title><title>Behavior genetics</title><addtitle>Behav Genet</addtitle><addtitle>Behav Genet</addtitle><description>The dopaminergic neurotransmitter system of the brain is involved in working memory and other cognitive functions. Studies suggest an important role for dopamine synthesis and uptake in modulation of human cognitive processes. We studied the association between polymorphisms in the catechol - o - methyl transferase ( COMT ) and dopamine receptor D2 ( DRD2 ) genes and general cognitive ability in a secondary analysis of 2091 men and women, aged 55–80 years living in Scotland. General cognitive ability ‘g’ was derived from five cognitive tests of different domains. COMT was not associated with cognitive ability in this population. The DRD2 C:C genotype of rs6277 was associated with decreased general cognitive ability ‘g’ ( p = 0.003), and DRD2 rs1800497 heterozygotes had lowest mean general cognitive ability ‘g’ ( p = 0.007). 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subjects	Age Aged Aged, 80 and over Atherosclerosis Behavioral Science and Psychology Brain Catechol O-Methyltransferase - genetics Clinical Psychology Cognition & reasoning Cognition - physiology Cognitive abilities Cognitive ability Cognitive functioning Cognitive processes Dopamine Dopamine - metabolism Enzymes Female Genes Genotype Health care Health Psychology Humans Male Memory Middle Aged Neuropsychological Tests Original Research Polymorphism, Single Nucleotide Psychology Public Health Receptors, Dopamine D2 - genetics Scotland
title	Association Between Polymorphisms of the Dopamine Receptor D2 and Catechol-o-Methyl Transferase Genes and Cognitive Function
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