Population Pharmacokinetics and Pharmacogenetics of Mycophenolic Acid Following Administration of Mycophenolate Mofetil in De Novo Pediatric Renal-Transplant Patients

The objective was to develop a population pharmacokinetic‐pharmacogenetic model of mycophenolic acid following administration of mycophenolate mofetil (MMF) in de novo pediatric renal‐transplant patients and identify factors that explain variability. The pharmacokinetic samples were collected from 8...

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Veröffentlicht in:	Journal of clinical pharmacology 2010-11, Vol.50 (11), p.1280-1291
Hauptverfasser:	Zhao, Wei, Fakhoury, May, Deschênes, Georges, Roussey, Gwenaelle, Brochard, Karine, Niaudet, Patrick, Tsimaratos, Michel, André, Jean Luc, Cloarec, Sylvie, Cochat, Pierre, Bensman, Albert, Azougagh, Saïd, Jacqz-Aigrain, Evelyne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Body Weight Child Child, Preschool Cyclosporine - administration & dosage Cyclosporine - therapeutic use Female Genotype Genotype & phenotype Glucuronosyltransferase - genetics Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacokinetics Infant Kidney Transplantation Male Models, Biological mycophenolate mofetil Mycophenolic Acid - administration & dosage Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - pharmacokinetics Nonlinear Dynamics Pediatric Pediatrics Pharmacogenetics pharmacokinetics Population Prospective Studies renal transplantation Tacrolimus - administration & dosage Tacrolimus - therapeutic use Tissue Distribution Transplants & implants UDP-glucuronosyltransferase
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