Genetic Ace2 Deficiency Accentuates Vascular Inflammation and Atherosclerosis in the ApoE Knockout Mouse

RATIONALE:Angiotensin-converting enzyme (ACE)2 opposes the actions of angiotensin (Ang) II by degrading it to Ang 1-7. OBJECTIVE:Given the important role of Ang II/Ang 1-7 in atherogenesis, we investigated the impact of ACE2 deficiency on the development of atherosclerosis. METHODS AND RESULTS:C57Bl...

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Veröffentlicht in:	Circulation research 2010-10, Vol.107 (7), p.888-897
Hauptverfasser:	Thomas, Merlin C, Pickering, Raelene J, Tsorotes, Despina, Koitka, Audrey, Sheehy, Karen, Bernardi, Stella, Toffoli, Barbara, Nguyen-Huu, Thu-Phuc, Head, Geoffrey A, Fu, Yi, Chin-Dusting, Jaye, Cooper, Mark E, Tikellis, Chris
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensins - blood Animals Aortic Diseases - immunology Aortic Diseases - pathology Aortic Diseases - physiopathology Apolipoproteins E - genetics Apolipoproteins E - metabolism Atherosclerosis (general aspects, experimental research) Atherosclerosis - immunology Atherosclerosis - pathology Atherosclerosis - physiopathology Biological and medical sciences Blood and lymphatic vessels Blood Pressure - physiology Cardiology. Vascular system Cell Line, Transformed Endothelial Cells - pathology Fundamental and applied biological sciences. Psychology Inflammation Mediators - metabolism Lipids - blood Macrophages - immunology Macrophages - pathology Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism Vasculitis - immunology Vasculitis - pathology Vasculitis - physiopathology Vertebrates: cardiovascular system
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